Annotation Detail for ADAMTS12
Basic Information Top
| Gene Symbol: | ADAMTS12 ( PRO4389 ) |
|---|---|
| Gene Full Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
| Band: | 5p13.3-p13.2 |
| Quick Links | Entrez ID:81792; OMIM: 606184; Uniprot ID:ATS12_HUMAN; ENSEMBL ID: ENSG00000151388; HGNC ID: 14605 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.12680
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 1 / 70761 | 14 |  |
| blastocyst | 2 / 62319 | 32 | |
| fetus | 31 / 564012 | 54 |  |
| neonate | 1 / 31097 | 32 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 32 / 1939121 | 16 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 4 / 82823 | 48 | |
| colorectal tumor | 3 / 114246 | 26 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 1 / 119369 | 8 |  |
| germ cell tumor | 6 / 263845 | 22 | |
| glioma | 1 / 106883 | 9 | |
| head and neck tumor | 2 / 136302 | 14 | |
| kidney tumor | 2 / 68959 | 29 | |
| leukemia | 1 / 95842 | 10 | |
| liver tumor | 2 / 96359 | 20 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 63 / 3360307 | 18 | |
| ovarian tumor | 3 / 76682 | 39 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 8 / 125191 | 63 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 6 / 71655 | 83 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 2 / 1100989 | 1 |  |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 10 / 149255 | 66 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 7 / 215722 | 32 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 8 / 89626 | 89 | |
| intestine | 3 / 234472 | 12 | |
| kidney | 4 / 211777 | 18 | |
| larynx | 0 / 24145 | 0 | |
| liver | 2 / 207743 | 9 | |
| lung | 4 / 336974 | 11 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 2 / 153271 | 13 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 1 / 107715 | 9 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 3 / 214812 | 13 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 1 / 41328 | 24 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 7 / 210574 | 33 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 1 / 96619 | 10 | |
| testis | 6 / 330442 | 18 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 1 / 13680 | 73 | |
| uterus | 2 / 232878 | 8 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 221421_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5 | |
| Adipocyte | 4.55 | |
| AdrenalCortex | 4.75 | |
| Adrenalgland | 4.1 | |
| Amygdala | 4.95 | |
| Appendix | 4.5 | |
| AtrioventricularNode | 7.35 | |
| BDCA4+_DentriticCells | 5.05 | |
| Bonemarrow | 7.75 | |
| BronchialEpithelialCells | 4.6 | |
| CD105+_Endothelial | 4.15 | |
| CD14+_Monocytes | 4.9 | |
| CD19+_BCells(neg._sel.) | 7.2 | |
| CD33+_Myeloid | 5.55 | |
| CD34+ | 5.15 | |
| CD4+_Tcells | 5.05 | |
| CD56+_NKCells | 5.15 | |
| CD71+_EarlyErythroid | 4.3 | |
| CD8+_Tcells | 4.5 | |
| CardiacMyocytes | 6.1 | |
| Caudatenucleus | 4.15 | |
| Cerebellum | 5 | |
| CerebellumPeduncles | 5.15 | |
| CiliaryGanglion | 3.3 | |
| CingulateCortex | 4.65 | |
| Colorectaladenocarcinoma | 4.6 | |
| DorsalRootGanglion | 5 | |
| FetalThyroid | 4.6 | |
| Fetalbrain | 4.65 | |
| Fetalliver | 4.1 | |
| Fetallung | 3.85 | |
| GlobusPallidus | 3.3 | |
| Heart | 6.55 | |
| Hypothalamus | 4.9 | |
| Kidney | 4.55 | |
| Leukemia_chronicMyelogenousK-562 | 4.15 | |
| Leukemia_promyelocytic-HL-60 | 4.05 | |
| Leukemialymphoblastic(MOLT-4) | 4.3 | |
| Liver | 11.4 | |
| Lung | 5.1 | |
| Lymphnode | 5.1 | |
| Lymphoma_burkitts(Daudi) | 6.6 | |
| Lymphoma_burkitts(Raji) | 8.85 | |
| MedullaOblongata | 4.25 | |
| OccipitalLobe | 4.1 | |
| OlfactoryBulb | 3.65 | |
| Ovary | 3.85 | |
| Pancreas | 4.45 | |
| PancreaticIslet | 5 | |
| ParietalLobe | 4.75 | |
| Pituitary | 5.35 | |
| Placenta | 4.85 | |
| Pons | 4.3 | |
| PrefrontalCortex | 5.8 | |
| Prostate | 6.05 | |
| Salivarygland | 3.65 | |
| SkeletalMuscle | 5.65 | |
| Skin | 4.85 | |
| SmoothMuscle | 5.8 | |
| Spinalcord | 4.75 | |
| SubthalamicNucleus | 4.1 | |
| SuperiorCervicalGanglion | 5.15 | |
| TemporalLobe | 4.15 | |
| Testis | 4 | |
| TestisGermCell | 3.95 | |
| TestisIntersitial | 3.85 | |
| TestisLeydigCell | 4.5 | |
| TestisSeminiferousTubule | 3.95 | |
| Thalamus | 4.6 | |
| Thymus | 3.5 | |
| Thyroid | 5.8 | |
| Tongue | 5.7 | |
| Tonsil | 4.45 | |
| Trachea | 4.65 | |
| TrigeminalGanglion | 5.35 | |
| Uterus | 3.85 | |
| UterusCorpus | 4.05 | |
| WholeBlood | 5.45 | |
| Wholebrain | 4.7 | |
| colon | 4.6 | |
| pineal_day | 5.28 | |
| pineal_night | 5.16 | |
| retina | 5.225 | |
| small_intestine | 4.45 | |
- Probe name: A_32_P103220
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.28 ± 1.15 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 1.65 ± 0.19 | |
| Basal Part of Pons | 1.41 ± 0.39 | |
| Cerebellar Cortex | 1.64 ± 0.9 | |
| Cerebellar Nuclei | 2 ± 0.66 | |
| Claustrum | 2.75 ± 1.06 | |
| Epithalamus | 1.42 ± 0.66 | |
| Frontal Lobe | 1.56 ± 0.59 | |
| Globus Pallidus | 2.34 ± 0.7 | |
| Hypothalamus | 1.69 ± 0.61 | |
| Insula | 1.63 ± 0.56 | |
| Limbic Lobe | 1.71 ± 0.73 | |
| Mesencephalon | 1.93 ± 0.73 | |
| Myelencephalon | 1.75 ± 0.7 | |
| Occipital Lobe | 1.8 ± 0.62 | |
| Parietal Lobe | 1.72 ± 0.73 | |
| Pontine Tegmentum | 1.78 ± 0.67 | |
| Striatum | 1.83 ± 0.5 | |
| Subthalamus | 1.91 ± 0.65 | |
| Temporal Lobe | 1.59 ± 0.56 | |
| Thalamus | 1.87 ± 0.69 | |
| White Matter | 3.13 ± 0.95 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Adamts12 | CB | Cerebellum | 21.06 | |
| 27.74 | | |||
| Adamts12 | CTX | Cerebral cortex | 12.14 | |
| 8.82 | | |||
| Adamts12 | HIP | Hippocampal region | 9.09 | |
| 8.87 | | |||
| Adamts12 | HPF | Hippocampal formation | 10.37 | |
| 9.2 | | |||
| Adamts12 | HY | Hypothalamus | 2.77 | |
| 2.22 | | |||
| Adamts12 | LSX | Lateral septal complex | 0.9 | |
| 1.44 | | |||
| Adamts12 | MB | Midbrain | 3.89 | |
| 4.34 | | |||
| Adamts12 | MY | Medulla | 7.15 | |
| 7.61 | | |||
| Adamts12 | OLF | Olfactory bulb | 24.36 | |
| 19 | | |||
| Adamts12 | P | Pons | 6.86 | |
| 7.26 | | |||
| Adamts12 | PAL | Pallidum | 4.22 | |
| 3.95 | | |||
| Adamts12 | RHP | Retrohippocampal region | 13.39 | |
| 10.09 | | |||
| Adamts12 | sAMY | Striatum-like amygdalar nuclei | 10.99 | |
| 8.57 | | |||
| Adamts12 | STR | Striatum | 7.9 | |
| 6.01 | | |||
| Adamts12 | STRd | Striatum dorsal region | 8.56 | |
| 6.59 | | |||
| Adamts12 | STRv | Striatum ventral region | 6.92 | |
| 4.71 | | |||
| Adamts12 | TH | Thalamus | 3.59 | |
| 3.72 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| ATS12_HUMAN_1181 | 25 | 1181 | 1205 | VPGNDAPVESTEMPLAPPLTPDLSR | PRIDE |