AutismKB 2.0

Annotation Detail for DGCR6


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Basic Information Top
Gene Symbol:DGCR6 ( - )
Gene Full Name: DiGeorge syndrome critical region gene 6
Band: 22q11.21
Quick LinksEntrez ID:8214; OMIM: 601279; Uniprot ID:DGCR6_HUMAN; ENSEMBL ID: ENSG00000183628; HGNC ID: 2846
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia4 / 9584241
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal91 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites0 / 400150 
bladder0 / 297570 
blood4 / 12347832
bone1 / 7165513
bone marrow0 / 488010 
brain43 / 110098939
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye5 / 21105423
heart1 / 8962611
intestine1 / 2344724
kidney6 / 21177728
larynx0 / 241450 
liver2 / 2077439
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth1 / 6705214
muscle18 / 107715167
nerve0 / 157680 
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate3 / 18934515
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208024_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts52.55
Adipocyte115.05
AdrenalCortex31.25
Adrenalgland94.05
Amygdala156.7
Appendix51.35
AtrioventricularNode26.85
BDCA4+_DentriticCells81.25
Bonemarrow67
BronchialEpithelialCells78.95
CD105+_Endothelial78.85
CD14+_Monocytes111.9
CD19+_BCells(neg._sel.)32.6
CD33+_Myeloid65.7
CD34+107.3
CD4+_Tcells166.6
CD56+_NKCells89.05
CD71+_EarlyErythroid29.05
CD8+_Tcells129.8
CardiacMyocytes87.15
Caudatenucleus148.9
Cerebellum59.95
CerebellumPeduncles152.15
CiliaryGanglion14.25
CingulateCortex90.85
Colorectaladenocarcinoma144.05
DorsalRootGanglion36.4
FetalThyroid114.75
Fetalbrain110.15
Fetalliver54.35
Fetallung90.5
GlobusPallidus39.1
Heart462.1
Hypothalamus149
Kidney115.5
Leukemia_chronicMyelogenousK-562148.5
Leukemia_promyelocytic-HL-6044.5
Leukemialymphoblastic(MOLT-4)151.75
Liver911.05
Lung396.95
Lymphnode65.95
Lymphoma_burkitts(Daudi)28.05
Lymphoma_burkitts(Raji)60.3
MedullaOblongata80.3
OccipitalLobe97.65
OlfactoryBulb72.8
Ovary20.05
Pancreas83.7
PancreaticIslet90.55
ParietalLobe78.25
Pituitary159.7
Placenta64.25
Pons97.3
PrefrontalCortex157.65
Prostate211.15
Salivarygland14.9
SkeletalMuscle98.45
Skin36.05
SmoothMuscle78.7
Spinalcord140.05
SubthalamicNucleus44.25
SuperiorCervicalGanglion43
TemporalLobe206.85
Testis458.6
TestisGermCell359.15
TestisIntersitial331.2
TestisLeydigCell231.95
TestisSeminiferousTubule221.8
Thalamus151
Thymus118.7
Thyroid472.7
Tongue118.3
Tonsil37.15
Trachea50.95
TrigeminalGanglion77.75
Uterus108.95
UterusCorpus36.85
WholeBlood84.3
Wholebrain267.4
colon45.8
pineal_day216.62
pineal_night228.28
retina195.625
small_intestine38.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P202948
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.34 ± 0.55
Basal Forebrain7.64 ± 0.24
Basal Part of Pons7.79 ± 0.48
Cerebellar Cortex7.49 ± 0.42
Cerebellar Nuclei7.47 ± 0.31
Claustrum7.01 ± 0.68
Epithalamus7.76 ± 0.47
Frontal Lobe7.72 ± 0.45
Globus Pallidus7.34 ± 0.43
Hypothalamus7.62 ± 0.57
Insula7.74 ± 0.38
Limbic Lobe7.41 ± 0.57
Mesencephalon7.53 ± 0.43
Myelencephalon7.55 ± 0.5
Occipital Lobe7 ± 0.47
Parietal Lobe7.48 ± 0.45
Pontine Tegmentum7.45 ± 0.52
Striatum7.35 ± 0.48
Subthalamus7.96 ± 0.26
Temporal Lobe7.75 ± 0.44
Thalamus7.55 ± 0.41
White Matter6.71 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dgcr6CBCerebellum8.55
9.32
Dgcr6CTXCerebral cortex12.69
9.26
Dgcr6HIPHippocampal region12.68
17.44
Dgcr6HPFHippocampal formation15.9
17.92
Dgcr6HYHypothalamus3.41
3.48
Dgcr6LSXLateral septal complex0.56
0.51
Dgcr6MBMidbrain5.09
5.24
Dgcr6MYMedulla11.23
14.05
Dgcr6OLFOlfactory bulb8.7
7.23
Dgcr6PPons7.49
9.45
Dgcr6PALPallidum3.9
4.06
Dgcr6RHPRetrohippocampal region21.48
19.57
Dgcr6sAMYStriatum-like amygdalar nuclei2.83
2.37
Dgcr6STRStriatum2.36
2.54
Dgcr6STRdStriatum dorsal region2.31
2.75
Dgcr6STRvStriatum ventral region2.66
2.41
Dgcr6THThalamus5.43
7
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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