AutismKB 2.0

Annotation Detail for LZTR1


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Basic Information Top
Gene Symbol:LZTR1 ( LZTR-1,MGC21205 )
Gene Full Name: leucine-zipper-like transcription regulator 1
Band: 22q11.21
Quick LinksEntrez ID:8216; OMIM: 600574; Uniprot ID:LZTR1_HUMAN; ENSEMBL ID: ENSG00000099949; HGNC ID: 6742
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus27 / 56401247
neonate0 / 310970 
infant0 / 236200 
juvenile4 / 5555671
adult87 / 193912144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor8 / 26384530
glioma9 / 10688384
head and neck tumor11 / 13630280
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal157 / 336030746
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer4 / 10268038
retinoblastoma5 / 46356107
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites1 / 4001524
bladder2 / 2975767
blood5 / 12347840
bone2 / 7165527
bone marrow1 / 4880120
brain79 / 110098971
cervix2 / 4817141
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye17 / 21105480
heart3 / 8962633
intestine5 / 23447221
kidney6 / 21177728
larynx2 / 2414582
liver2 / 2077439
lung8 / 33697423
lymph0 / 442700 
lymph node2 / 9161021
mammary gland8 / 15327152
mouth4 / 6705259
muscle1 / 1077159
nerve1 / 1576863
ovary2 / 10205119
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate9 / 18934547
salivary gland0 / 201550 
skin9 / 21057442
spleen2 / 5395237
stomach8 / 9661982
testis22 / 33044266
thymus5 / 8113161
thyroid7 / 47473147
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203412_at
Cell line Expression level Expression bar
721_B_lymphoblasts76.35
Adipocyte67.85
AdrenalCortex85.6
Adrenalgland51.9
Amygdala39.75
Appendix46.65
AtrioventricularNode48.45
BDCA4+_DentriticCells89.95
Bonemarrow62.2
BronchialEpithelialCells62.6
CD105+_Endothelial43.75
CD14+_Monocytes72.3
CD19+_BCells(neg._sel.)78.2
CD33+_Myeloid103.95
CD34+92.7
CD4+_Tcells107.8
CD56+_NKCells83.35
CD71+_EarlyErythroid58.85
CD8+_Tcells102.75
CardiacMyocytes75.85
Caudatenucleus63.5
Cerebellum51.2
CerebellumPeduncles71.75
CiliaryGanglion55.75
CingulateCortex100.85
Colorectaladenocarcinoma48.6
DorsalRootGanglion82.35
FetalThyroid71.55
Fetalbrain85.9
Fetalliver38.8
Fetallung52.3
GlobusPallidus48.3
Heart80.65
Hypothalamus75.55
Kidney52.4
Leukemia_chronicMyelogenousK-562163.5
Leukemia_promyelocytic-HL-6062.05
Leukemialymphoblastic(MOLT-4)50.9
Liver84.85
Lung69.75
Lymphnode94.35
Lymphoma_burkitts(Daudi)80.25
Lymphoma_burkitts(Raji)91.15
MedullaOblongata58.45
OccipitalLobe49.85
OlfactoryBulb84.7
Ovary42
Pancreas30.9
PancreaticIslet67.55
ParietalLobe68.05
Pituitary77.95
Placenta37.2
Pons62.5
PrefrontalCortex80.8
Prostate73.1
Salivarygland51.1
SkeletalMuscle62.25
Skin48.9
SmoothMuscle50.7
Spinalcord105.8
SubthalamicNucleus50.15
SuperiorCervicalGanglion61.5
TemporalLobe62.7
Testis54.15
TestisGermCell45.35
TestisIntersitial40.55
TestisLeydigCell62.15
TestisSeminiferousTubule54.6
Thalamus90.5
Thymus48.95
Thyroid82.75
Tongue46.85
Tonsil57.4
Trachea40.1
TrigeminalGanglion63.85
Uterus41.6
UterusCorpus57.35
WholeBlood60.25
Wholebrain45.3
colon30.7
pineal_day81.58
pineal_night99.52
retina81.1
small_intestine35.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8993_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.09 ± 0.83
Basal Forebrain2.38 ± 0.31
Basal Part of Pons2.31 ± 0.59
Cerebellar Cortex2.6 ± 0.68
Cerebellar Nuclei2.59 ± 0.7
Claustrum3.18 ± 0.74
Epithalamus2.07 ± 0.73
Frontal Lobe2.5 ± 0.71
Globus Pallidus2.48 ± 0.81
Hypothalamus2.55 ± 0.61
Insula2.47 ± 0.59
Limbic Lobe2.45 ± 0.71
Mesencephalon2.64 ± 0.74
Myelencephalon2.5 ± 0.68
Occipital Lobe2.34 ± 0.71
Parietal Lobe2.31 ± 0.72
Pontine Tegmentum2.43 ± 0.72
Striatum2.2 ± 0.79
Subthalamus2.45 ± 0.73
Temporal Lobe2.55 ± 0.78
Thalamus2.43 ± 0.66
White Matter3.19 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lztr1CBCerebellum28.56
35.26
Lztr1CTXCerebral cortex100
100
Lztr1HIPHippocampal region82.92
100
Lztr1HPFHippocampal formation93.29
100
Lztr1HYHypothalamus61.75
53.24
Lztr1LSXLateral septal complex100
94.95
Lztr1MBMidbrain49.67
51.28
Lztr1MYMedulla59.89
84.34
Lztr1OLFOlfactory bulb95.12
100
Lztr1PPons55.2
67.42
Lztr1PALPallidum53.57
52.7
Lztr1RHPRetrohippocampal region100
100
Lztr1sAMYStriatum-like amygdalar nuclei73.02
62.87
Lztr1STRStriatum54.36
44.39
Lztr1STRdStriatum dorsal region45.23
37.2
Lztr1STRvStriatum ventral region55.82
42.3
Lztr1THThalamus94.21
98.79
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LZTR1_HUMAN_2 20 2 21 AGPGSTGGQIGAAALAGGAR PRIDE
PAp00132195 21 811 831 SLSQQLLLDIIDSLASHISDK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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