AutismKB 2.0

Annotation Detail for USP11


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Basic Information Top
Gene Symbol:USP11 ( UHX1 )
Gene Full Name: ubiquitin specific peptidase 11
Band: Xp11.3
Quick LinksEntrez ID:8237; OMIM: 300050; Uniprot ID:UBP11_HUMAN; ENSEMBL ID: ENSG00000102226; HGNC ID: 12609
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst10 / 62319160
fetus698 / 5640121237
neonate7 / 31097225
infant2 / 2362084
juvenile23 / 55556413
adult473 / 1939121243
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor27 / 94178286
cervical tumor12 / 34366349
chondrosarcoma6 / 8282372
colorectal tumor26 / 114246227
esophageal tumor1 / 1729057
gastrointestinal tumor19 / 119369159
germ cell tumor244 / 263845924
glioma48 / 106883449
head and neck tumor39 / 136302286
kidney tumor24 / 68959348
leukemia12 / 95842125
liver tumor24 / 96359249
lung tumor29 / 103127281
lymphoma18 / 71755250
non-neoplasia9 / 9725092
normal1687 / 3360307502
ovarian tumor8 / 76682104
pancreatic tumor47 / 104616449
primitive neuroectodermal tumor of the CNS36 / 125680286
prostate cancer5 / 10268048
retinoblastoma11 / 46356237
skin tumor26 / 124949208
soft tissue/muscle tissue tumor36 / 125191287
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites6 / 40015149
bladder3 / 29757100
blood16 / 123478129
bone3 / 7165541
bone marrow3 / 4880161
brain1473 / 11009891337
cervix18 / 48171373
connective tissue14 / 14925593
ear5 / 16212308
embryonic tissue38 / 215722176
esophagus1 / 2020949
eye42 / 211054199
heart8 / 8962689
intestine43 / 234472183
kidney53 / 211777250
larynx0 / 241450 
liver31 / 207743149
lung93 / 336974275
lymph14 / 44270316
lymph node10 / 91610109
mammary gland29 / 153271189
mouth38 / 67052566
muscle18 / 107715167
nerve5 / 15768317
ovary21 / 102051205
pancreas59 / 214812274
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland6 / 16585361
placenta21 / 28082574
prostate21 / 189345110
salivary gland1 / 2015549
skin42 / 210574199
spleen39 / 53952722
stomach11 / 96619113
testis245 / 330442741
thymus80 / 81131986
thyroid10 / 47473210
tonsil3 / 16999176
trachea8 / 52413152
umbilical cord2 / 13680146
uterus60 / 232878257
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208723_at
Cell line Expression level Expression bar
721_B_lymphoblasts220.55
Adipocyte21.5
AdrenalCortex25.8
Adrenalgland21.45
Amygdala944.25
Appendix14.2
AtrioventricularNode11.35
BDCA4+_DentriticCells175.95
Bonemarrow12.25
BronchialEpithelialCells14.7
CD105+_Endothelial47.1
CD14+_Monocytes13.6
CD19+_BCells(neg._sel.)182.6
CD33+_Myeloid13
CD34+164.5
CD4+_Tcells197.55
CD56+_NKCells176.35
CD71+_EarlyErythroid26.3
CD8+_Tcells248.65
CardiacMyocytes47.55
Caudatenucleus359.1
Cerebellum211.85
CerebellumPeduncles459.05
CiliaryGanglion18.05
CingulateCortex714.35
Colorectaladenocarcinoma321.8
DorsalRootGanglion23.4
FetalThyroid156.5
Fetalbrain468.95
Fetalliver14.7
Fetallung26.8
GlobusPallidus410
Heart141.2
Hypothalamus882.6
Kidney19.5
Leukemia_chronicMyelogenousK-56216.05
Leukemia_promyelocytic-HL-6033.25
Leukemialymphoblastic(MOLT-4)202.45
Liver52.6
Lung306
Lymphnode24.35
Lymphoma_burkitts(Daudi)18
Lymphoma_burkitts(Raji)126.05
MedullaOblongata503.5
OccipitalLobe780.25
OlfactoryBulb150.6
Ovary94.8
Pancreas14.05
PancreaticIslet103.65
ParietalLobe547.45
Pituitary477.5
Placenta64.3
Pons390.65
PrefrontalCortex1036.65
Prostate276.75
Salivarygland9.8
SkeletalMuscle14.8
Skin9.5
SmoothMuscle28.8
Spinalcord144.9
SubthalamicNucleus394.55
SuperiorCervicalGanglion13.8
TemporalLobe812.5
Testis98.65
TestisGermCell123.7
TestisIntersitial39.1
TestisLeydigCell38.4
TestisSeminiferousTubule69.9
Thalamus286.15
Thymus154.7
Thyroid396.85
Tongue14.7
Tonsil15.4
Trachea21.2
TrigeminalGanglion31.2
Uterus99.9
UterusCorpus43.85
WholeBlood13.4
Wholebrain1062
colon14.75
pineal_day1425.86
pineal_night1358.7
retina598.3
small_intestine24.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P171366
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.76 ± 0.28
Basal Forebrain11.93 ± 0.27
Basal Part of Pons11.76 ± 0.16
Cerebellar Cortex11.6 ± 0.2
Cerebellar Nuclei11.43 ± 0.26
Claustrum12.06 ± 0.16
Epithalamus11.82 ± 0.22
Frontal Lobe11.76 ± 0.32
Globus Pallidus10.99 ± 0.38
Hypothalamus12.21 ± 0.29
Insula11.94 ± 0.16
Limbic Lobe11.63 ± 0.4
Mesencephalon11.72 ± 0.34
Myelencephalon11.68 ± 0.39
Occipital Lobe11.48 ± 0.34
Parietal Lobe11.75 ± 0.29
Pontine Tegmentum11.72 ± 0.38
Striatum11.53 ± 0.47
Subthalamus11.61 ± 0.24
Temporal Lobe11.91 ± 0.26
Thalamus11.6 ± 0.24
White Matter10.97 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp11CBCerebellum20.31
27.56
Usp11CTXCerebral cortex100
100
Usp11HIPHippocampal region100
100
Usp11HPFHippocampal formation100
100
Usp11HYHypothalamus100
100
Usp11LSXLateral septal complex100
100
Usp11MBMidbrain98.95
100
Usp11MYMedulla64.66
75.91
Usp11OLFOlfactory bulb100
100
Usp11PPons79.05
93.99
Usp11PALPallidum100
100
Usp11RHPRetrohippocampal region100
100
Usp11sAMYStriatum-like amygdalar nuclei100
100
Usp11STRStriatum100
100
Usp11STRdStriatum dorsal region100
100
Usp11STRvStriatum ventral region100
100
Usp11THThalamus79.96
87.65
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00067050 25 423 447 EYVELCDAAGRPDQEVAQEAWQNHK Peptide Atlas
UBP11_HUMAN_452 12 452 463 VLEVFFIPMDPR PRIDE
UBP11_HUMAN_487 10 487 496 SKHTGISPER PRIDE
UBP11_HUMAN_497 10 497 506 MMVADVFSHR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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