AutismKB 2.0

Annotation Detail for USP9X


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Basic Information Top
Gene Symbol:USP9X ( DFFRX,FAF,FAM )
Gene Full Name: ubiquitin specific peptidase 9, X-linked
Band: Xp11.4
Quick LinksEntrez ID:8239; OMIM: 300072; Uniprot ID:USP9X_HUMAN; ENSEMBL ID: ENSG00000124486; HGNC ID: 12632
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst21 / 62319336
fetus99 / 564012175
neonate0 / 310970 
infant1 / 2362042
juvenile4 / 5555671
adult298 / 1939121153
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor6 / 9417863
cervical tumor9 / 34366261
chondrosarcoma11 / 82823132
colorectal tumor24 / 114246210
esophageal tumor0 / 172900 
gastrointestinal tumor17 / 119369142
germ cell tumor47 / 263845178
glioma3 / 10688328
head and neck tumor16 / 136302117
kidney tumor9 / 68959130
leukemia6 / 9584262
liver tumor13 / 96359134
lung tumor8 / 10312777
lymphoma2 / 7175527
non-neoplasia7 / 9725071
normal459 / 3360307136
ovarian tumor7 / 7668291
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer2 / 10268019
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites11 / 40015274
bladder5 / 29757168
blood3 / 12347824
bone11 / 71655153
bone marrow6 / 48801122
brain91 / 110098982
cervix9 / 48171186
connective tissue11 / 14925573
ear2 / 16212123
embryonic tissue41 / 215722190
esophagus0 / 202090 
eye23 / 211054108
heart12 / 89626133
intestine28 / 234472119
kidney25 / 211777118
larynx0 / 241450 
liver16 / 20774377
lung110 / 336974326
lymph0 / 442700 
lymph node11 / 91610120
mammary gland17 / 153271110
mouth10 / 67052149
muscle12 / 107715111
nerve2 / 15768126
ovary7 / 10205168
pancreas14 / 21481265
parathyroid1 / 2053948
pharynx3 / 4132872
pituitary gland4 / 16585241
placenta44 / 280825156
prostate10 / 18934552
salivary gland1 / 2015549
skin19 / 21057490
spleen3 / 5395255
stomach10 / 96619103
testis55 / 330442166
thymus6 / 8113173
thyroid4 / 4747384
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus26 / 232878111
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201100_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts624.1
Adipocyte171.5
AdrenalCortex173.25
Adrenalgland82.7
Amygdala174.2
Appendix117.1
AtrioventricularNode73.3
BDCA4+_DentriticCells386.05
Bonemarrow96.5
BronchialEpithelialCells321.5
CD105+_Endothelial364
CD14+_Monocytes249.35
CD19+_BCells(neg._sel.)299.9
CD33+_Myeloid305.25
CD34+324.3
CD4+_Tcells313.45
CD56+_NKCells181.65
CD71+_EarlyErythroid653.6
CD8+_Tcells429.5
CardiacMyocytes127.05
Caudatenucleus90.45
Cerebellum51
CerebellumPeduncles149.7
CiliaryGanglion68.45
CingulateCortex280.5
Colorectaladenocarcinoma102.85
DorsalRootGanglion76.4
FetalThyroid111.75
Fetalbrain146.35
Fetalliver155.6
Fetallung92.1
GlobusPallidus85.85
Heart101.45
Hypothalamus246.2
Kidney50.55
Leukemia_chronicMyelogenousK-562126.25
Leukemia_promyelocytic-HL-60106.65
Leukemialymphoblastic(MOLT-4)91.05
Liver126.1
Lung50.45
Lymphnode112.3
Lymphoma_burkitts(Daudi)126.2
Lymphoma_burkitts(Raji)118.35
MedullaOblongata226
OccipitalLobe282.45
OlfactoryBulb178.75
Ovary65.15
Pancreas91.6
PancreaticIslet215.15
ParietalLobe152.75
Pituitary196.3
Placenta554
Pons109.05
PrefrontalCortex378.55
Prostate121
Salivarygland113.05
SkeletalMuscle123.95
Skin74.7
SmoothMuscle302.75
Spinalcord121
SubthalamicNucleus106.4
SuperiorCervicalGanglion110.8
TemporalLobe111.85
Testis77.45
TestisGermCell418.65
TestisIntersitial158.85
TestisLeydigCell138
TestisSeminiferousTubule146.35
Thalamus103.25
Thymus77.1
Thyroid132.05
Tongue136.25
Tonsil145.1
Trachea82.45
TrigeminalGanglion96.3
Uterus155.8
UterusCorpus87.95
WholeBlood163.95
Wholebrain84.75
colon284.15
pineal_day432.08
pineal_night441.88
retina171.1
small_intestine265.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10333_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.52 ± 0.25
Basal Forebrain5.46 ± 0.26
Basal Part of Pons5.59 ± 0.28
Cerebellar Cortex5.35 ± 0.31
Cerebellar Nuclei5.23 ± 0.39
Claustrum5.59 ± 0.4
Epithalamus5.39 ± 0.43
Frontal Lobe5.54 ± 0.31
Globus Pallidus5.19 ± 0.37
Hypothalamus5.53 ± 0.12
Insula5.43 ± 0.39
Limbic Lobe5.57 ± 0.43
Mesencephalon5.46 ± 0.32
Myelencephalon5.39 ± 0.36
Occipital Lobe5.2 ± 0.39
Parietal Lobe5.45 ± 0.27
Pontine Tegmentum5.46 ± 0.39
Striatum5.17 ± 0.36
Subthalamus5.06 ± 0.45
Temporal Lobe5.55 ± 0.31
Thalamus5.35 ± 0.22
White Matter5.47 ± 0.19
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp9xCBCerebellum36.06
53.86
Usp9xCTXCerebral cortex69.88
63.74
Usp9xHIPHippocampal region44.57
78.17
Usp9xHPFHippocampal formation51.99
68.58
Usp9xHYHypothalamus71.37
66.14
Usp9xLSXLateral septal complex53.57
46.97
Usp9xMBMidbrain57.93
61.07
Usp9xMYMedulla52.72
67.41
Usp9xOLFOlfactory bulb58.46
56.75
Usp9xPPons56.47
70.34
Usp9xPALPallidum56.91
62.01
Usp9xRHPRetrohippocampal region65.1
58.88
Usp9xsAMYStriatum-like amygdalar nuclei51.03
44.13
Usp9xSTRStriatum34.22
29.43
Usp9xSTRdStriatum dorsal region27.45
23.58
Usp9xSTRvStriatum ventral region40.76
33.84
Usp9xTHThalamus53.8
53.7
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00038136 19 1417 1435 TGETGIEETILEGHLGVTK Peptide Atlas
USP9X_HUMAN_1113 13 1113 1125 SGGLPLVLSMLTR PRIDE
USP9X_HUMAN_1986 10 1986 1995 KQNVQFMHNR PRIDE
USP9X_HUMAN_586 7 586 592 SPHVFYR PRIDE
USP9X_HUMAN_75 9 75 83 LDDMINRPR PRIDE
USP9X_HUMAN_878 13 878 890 HLSFVVRFPNQGR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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