AutismKB 2.0

Annotation Detail for CAPN2


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Basic Information Top
Gene Symbol:CAPN2 ( CANP2,CANPL2,CANPml,FLJ39928,mCANP )
Gene Full Name: calpain 2, (m/II) large subunit
Band: 1q41
Quick LinksEntrez ID:824; OMIM: 114230; Uniprot ID:CAN2_HUMAN; ENSEMBL ID: ENSG00000162909; HGNC ID: 1479
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body25 / 70761353
blastocyst6 / 6231996
fetus39 / 56401269
neonate8 / 31097257
infant0 / 236200 
juvenile3 / 5555653
adult338 / 1939121174
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor10 / 94178106
cervical tumor4 / 34366116
chondrosarcoma27 / 82823325
colorectal tumor26 / 114246227
esophageal tumor3 / 17290173
gastrointestinal tumor14 / 119369117
germ cell tumor42 / 263845159
glioma15 / 106883140
head and neck tumor43 / 136302315
kidney tumor12 / 68959174
leukemia7 / 9584273
liver tumor29 / 96359300
lung tumor35 / 103127339
lymphoma5 / 7175569
non-neoplasia30 / 97250308
normal501 / 3360307149
ovarian tumor5 / 7668265
pancreatic tumor33 / 104616315
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer9 / 10268087
retinoblastoma0 / 463560 
skin tumor22 / 124949176
soft tissue/muscle tissue tumor18 / 125191143
uterine tumor18 / 90257199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland7 / 33197210
ascites3 / 4001574
bladder1 / 2975733
blood13 / 123478105
bone10 / 71655139
bone marrow5 / 48801102
brain129 / 1100989117
cervix5 / 48171103
connective tissue24 / 149255160
ear3 / 16212185
embryonic tissue45 / 215722208
esophagus3 / 20209148
eye21 / 21105499
heart9 / 89626100
intestine48 / 234472204
kidney50 / 211777236
larynx1 / 2414541
liver35 / 207743168
lung120 / 336974356
lymph0 / 442700 
lymph node9 / 9161098
mammary gland30 / 153271195
mouth31 / 67052462
muscle12 / 107715111
nerve3 / 15768190
ovary9 / 10205188
pancreas44 / 214812204
parathyroid8 / 20539389
pharynx9 / 41328217
pituitary gland1 / 1658560
placenta28 / 28082599
prostate25 / 189345132
salivary gland1 / 2015549
skin43 / 210574204
spleen10 / 53952185
stomach16 / 96619165
testis57 / 330442172
thymus2 / 8113124
thyroid12 / 47473252
tonsil0 / 169990 
trachea24 / 52413457
umbilical cord2 / 13680146
uterus55 / 232878236
vascular15 / 51780289
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208683_at
Cell line Expression level Expression bar
721_B_lymphoblasts385
Adipocyte795.55
AdrenalCortex405.15
Adrenalgland267.8
Amygdala194.05
Appendix239.5
AtrioventricularNode100.25
BDCA4+_DentriticCells652.65
Bonemarrow43.1
BronchialEpithelialCells1725.65
CD105+_Endothelial76.15
CD14+_Monocytes1373.45
CD19+_BCells(neg._sel.)458.8
CD33+_Myeloid2341.15
CD34+115.95
CD4+_Tcells1112.75
CD56+_NKCells1582.15
CD71+_EarlyErythroid4.15
CD8+_Tcells1153.25
CardiacMyocytes713.7
Caudatenucleus191.5
Cerebellum114.5
CerebellumPeduncles120.35
CiliaryGanglion151.65
CingulateCortex131.45
Colorectaladenocarcinoma490.45
DorsalRootGanglion151.75
FetalThyroid566.95
Fetalbrain146.4
Fetalliver27.45
Fetallung598.05
GlobusPallidus55.35
Heart31.85
Hypothalamus348.1
Kidney185.5
Leukemia_chronicMyelogenousK-562470.8
Leukemia_promyelocytic-HL-603.8
Leukemialymphoblastic(MOLT-4)3.5
Liver5.8
Lung864.1
Lymphnode252.2
Lymphoma_burkitts(Daudi)5.45
Lymphoma_burkitts(Raji)5.5
MedullaOblongata105
OccipitalLobe160.1
OlfactoryBulb294.3
Ovary176.05
Pancreas181.8
PancreaticIslet351.3
ParietalLobe123.25
Pituitary254.5
Placenta254.2
Pons73.55
PrefrontalCortex252.35
Prostate191.55
Salivarygland503.4
SkeletalMuscle6.15
Skin117.7
SmoothMuscle1071.05
Spinalcord447.3
SubthalamicNucleus77.95
SuperiorCervicalGanglion99.5
TemporalLobe26.95
Testis94.9
TestisGermCell358.4
TestisIntersitial117.9
TestisLeydigCell133.8
TestisSeminiferousTubule153.8
Thalamus231.6
Thymus100.7
Thyroid584.85
Tongue341.45
Tonsil204
Trachea623.35
TrigeminalGanglion129.65
Uterus304.55
UterusCorpus118.25
WholeBlood544.45
Wholebrain113.7
colon657.05
pineal_day357.08
pineal_night321.62
retina438.525
small_intestine226.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12666_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.26 ± 0.36
Basal Forebrain9.39 ± 0.25
Basal Part of Pons9.12 ± 0.29
Cerebellar Cortex9.14 ± 0.19
Cerebellar Nuclei9.68 ± 0.38
Claustrum9.28 ± 0.32
Epithalamus9.64 ± 0.26
Frontal Lobe9.12 ± 0.37
Globus Pallidus10.41 ± 0.3
Hypothalamus9.14 ± 0.45
Insula9.05 ± 0.28
Limbic Lobe9.15 ± 0.44
Mesencephalon9.46 ± 0.38
Myelencephalon9.31 ± 0.41
Occipital Lobe9.55 ± 0.37
Parietal Lobe9.27 ± 0.38
Pontine Tegmentum9.33 ± 0.38
Striatum9.72 ± 0.46
Subthalamus9.41 ± 0.24
Temporal Lobe9.05 ± 0.33
Thalamus9.54 ± 0.27
White Matter10.27 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Capn2CBCerebellum19.92
43.16
Capn2CTXCerebral cortex18.7
15.85
Capn2HIPHippocampal region9.75
10.56
Capn2HPFHippocampal formation10.63
10.16
Capn2HYHypothalamus7.97
7.11
Capn2LSXLateral septal complex3.82
3.47
Capn2MBMidbrain15.97
17.88
Capn2MYMedulla32.46
47.27
Capn2OLFOlfactory bulb18.43
17.47
Capn2PPons26.38
34.32
Capn2PALPallidum15.55
16.93
Capn2RHPRetrohippocampal region12.43
9.94
Capn2sAMYStriatum-like amygdalar nuclei5.77
5.03
Capn2STRStriatum5.11
4.94
Capn2STRdStriatum dorsal region4.49
4.7
Capn2STRvStriatum ventral region7.27
6.05
Capn2THThalamus19.31
18.25
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CAN2_HUMAN_1 11 1 11 AGIAAKLAKDR PRIDE
CAN2_HUMAN_2 11 2 12 AGIAAKLAKDR PRIDE
CAN2_HUMAN_260 20 260 279 GHAYSVTGAEEVESNGSLQK PRIDE
CAN2_HUMAN_283 13 283 295 IRNPWGEVEWTGR PRIDE
CAN2_HUMAN_337 18 337 354 LEICNLTPDTLTSDTYKK PRIDE
CAN2_HUMAN_375 15 375 389 NYPNTFWMNPQYLIK PRIDE
CAN2_HUMAN_421 29 421 449 MGEDMHTIGFGIYEVPEELSGQTNIHLSK PRIDE
CAN2_HUMAN_474 26 474 499 FKLPPGEYILVPSTFEPNKDGDFCIR PRIDE
CAN2_HUMAN_536 23 536 558 LFAQLAGEDAEISAFELQTILRR PRIDE
CAN2_HUMAN_578 13 578 590 IMVDMLDSDGSGK PRIDE
CAN2_HUMAN_618 10 618 627 SGTMNSYEMR PRIDE
CAN2_HUMAN_619 10 619 628 SGTMNSYEMR PRIDE
CAN2_HUMAN_637 12 637 648 MPCQLHQVIVAR PRIDE
CAN2_HUMAN_649 15 649 663 FADDQLIIDFDNFVR PRIDE
CAN2_HUMAN_76 18 76 93 RPTEICADPQFIIGGATR PRIDE
PAp00002468 26 475 500 FKLPPGEYILVPSTFEPNKDGDFCIR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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