AutismKB 2.0

Annotation Detail for FZD8


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Basic Information Top
Gene Symbol:FZD8 ( FZ-8,hFZ8 )
Gene Full Name: frizzled homolog 8 (Drosophila)
Band: 10p11.21
Quick LinksEntrez ID:8325; OMIM: 606146; Uniprot ID:FZD8_HUMAN; ENSEMBL ID: ENSG00000177283; HGNC ID: 4046
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus16 / 56401228
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal56 / 336030716
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain2 / 11009891
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye12 / 21105456
heart3 / 8962633
intestine1 / 2344724
kidney4 / 21177718
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas9 / 21481241
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216587_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts3.8
Adipocyte2.95
AdrenalCortex3.1
Adrenalgland2.5
Amygdala3.2
Appendix3
AtrioventricularNode2.3
BDCA4+_DentriticCells3.4
Bonemarrow2.9
BronchialEpithelialCells3
CD105+_Endothelial3.05
CD14+_Monocytes3.25
CD19+_BCells(neg._sel.)3.25
CD33+_Myeloid3.9
CD34+3.9
CD4+_Tcells3.35
CD56+_NKCells3.7
CD71+_EarlyErythroid2.8
CD8+_Tcells2.95
CardiacMyocytes3.8
Caudatenucleus2.75
Cerebellum2.45
CerebellumPeduncles3.4
CiliaryGanglion2.15
CingulateCortex3.05
Colorectaladenocarcinoma3
DorsalRootGanglion2.25
FetalThyroid2.95
Fetalbrain3.05
Fetalliver2.55
Fetallung2.55
GlobusPallidus2.15
Heart4.65
Hypothalamus3.3
Kidney2.4
Leukemia_chronicMyelogenousK-5622.75
Leukemia_promyelocytic-HL-602.7
Leukemialymphoblastic(MOLT-4)2.45
Liver3.95
Lung3.35
Lymphnode2.6
Lymphoma_burkitts(Daudi)3.85
Lymphoma_burkitts(Raji)4.2
MedullaOblongata2.8
OccipitalLobe2.75
OlfactoryBulb2.35
Ovary1.95
Pancreas2.45
PancreaticIslet3.25
ParietalLobe3.1
Pituitary3.5
Placenta3.15
Pons2.85
PrefrontalCortex3.85
Prostate3.6
Salivarygland2.4
SkeletalMuscle3.4
Skin2.35
SmoothMuscle3.45
Spinalcord3.2
SubthalamicNucleus2.75
SuperiorCervicalGanglion3.35
TemporalLobe2.75
Testis2.6
TestisGermCell2.55
TestisIntersitial2.55
TestisLeydigCell2.95
TestisSeminiferousTubule2.6
Thalamus3.05
Thymus2.45
Thyroid3.85
Tongue2.95
Tonsil2.95
Trachea2.55
TrigeminalGanglion2.95
Uterus2.5
UterusCorpus2.7
WholeBlood3.35
Wholebrain2.65
colon3.05
pineal_day3.76
pineal_night3.7
retina3.675
small_intestine2.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10917_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3 ± 0.88
Basal Forebrain2.42 ± 0.3
Basal Part of Pons2.11 ± 0.48
Cerebellar Cortex3.12 ± 0.56
Cerebellar Nuclei2.67 ± 0.68
Claustrum3.12 ± 0.8
Epithalamus2.43 ± 0.77
Frontal Lobe2.59 ± 0.68
Globus Pallidus2.05 ± 0.79
Hypothalamus2.25 ± 0.53
Insula2.42 ± 0.79
Limbic Lobe2.71 ± 0.6
Mesencephalon2.82 ± 0.92
Myelencephalon2.63 ± 0.71
Occipital Lobe2.48 ± 0.63
Parietal Lobe2.36 ± 0.72
Pontine Tegmentum2.63 ± 0.43
Striatum2.97 ± 0.63
Subthalamus2.79 ± 0.9
Temporal Lobe2.61 ± 0.77
Thalamus2.66 ± 0.66
White Matter2.11 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fzd8CBCerebellum13.1
12.79
Fzd8CTXCerebral cortex9.35
5.72
Fzd8HIPHippocampal region54.83
36.48
Fzd8HPFHippocampal formation43.16
27.6
Fzd8HYHypothalamus24.48
17.35
Fzd8LSXLateral septal complex7.7
4.9
Fzd8MBMidbrain20.36
16.14
Fzd8MYMedulla29.91
30.1
Fzd8OLFOlfactory bulb26.5
15
Fzd8PPons29.86
29.44
Fzd8PALPallidum11.92
9.91
Fzd8RHPRetrohippocampal region19.51
12.96
Fzd8sAMYStriatum-like amygdalar nuclei14.69
9.63
Fzd8STRStriatum5.38
3.38
Fzd8STRdStriatum dorsal region2.71
1.89
Fzd8STRvStriatum ventral region7.61
4.07
Fzd8THThalamus13.49
9.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FZD8_HUMAN_0 0 0 0 CDRLPEQGNPDTLCMDYNRTDLTTAAPSPPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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