AutismKB 2.0

Annotation Detail for TCF7L1


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Basic Information Top
Gene Symbol:TCF7L1 ( TCF-3,TCF3 )
Gene Full Name: transcription factor 7-like 1 (T-cell specific, HMG-box)
Band: 2p11.2
Quick LinksEntrez ID:83439; OMIM: 604652; Uniprot ID:TF7L1_HUMAN; ENSEMBL ID: ENSG00000152284; HGNC ID: 11640
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst6 / 6231996
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult38 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma12 / 106883112
head and neck tumor0 / 1363020 
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal76 / 336030722
ovarian tumor5 / 7668265
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer6 / 10268058
retinoblastoma2 / 4635643
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow1 / 4880120
brain15 / 110098913
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye6 / 21105428
heart5 / 8962655
intestine3 / 23447212
kidney2 / 2117779
larynx1 / 2414541
liver0 / 2077430 
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland14 / 15327191
mouth0 / 670520 
muscle6 / 10771555
nerve0 / 157680 
ovary5 / 10205148
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate8 / 18934542
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221016_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.85
Adipocyte20.15
AdrenalCortex17.4
Adrenalgland12.7
Amygdala16.3
Appendix26.1
AtrioventricularNode12.45
BDCA4+_DentriticCells5.5
Bonemarrow14.8
BronchialEpithelialCells15.25
CD105+_Endothelial12.6
CD14+_Monocytes14.5
CD19+_BCells(neg._sel.)14.3
CD33+_Myeloid18.05
CD34+13.7
CD4+_Tcells15.75
CD56+_NKCells13.5
CD71+_EarlyErythroid14.05
CD8+_Tcells14.95
CardiacMyocytes25.95
Caudatenucleus13.75
Cerebellum12.4
CerebellumPeduncles17.3
CiliaryGanglion14.45
CingulateCortex15.6
Colorectaladenocarcinoma15.25
DorsalRootGanglion18.25
FetalThyroid40.05
Fetalbrain16.25
Fetalliver27.05
Fetallung44.6
GlobusPallidus11.05
Heart19.05
Hypothalamus19.4
Kidney15.15
Leukemia_chronicMyelogenousK-56213.85
Leukemia_promyelocytic-HL-6013.45
Leukemialymphoblastic(MOLT-4)11.45
Liver44.05
Lung82.55
Lymphnode22.6
Lymphoma_burkitts(Daudi)19.3
Lymphoma_burkitts(Raji)20.75
MedullaOblongata14.1
OccipitalLobe13.75
OlfactoryBulb24.25
Ovary21.1
Pancreas12.3
PancreaticIslet16.35
ParietalLobe15.8
Pituitary18.3
Placenta16.1
Pons14.45
PrefrontalCortex19.25
Prostate21.2
Salivarygland15.55
SkeletalMuscle18.75
Skin18.25
SmoothMuscle34.7
Spinalcord16.4
SubthalamicNucleus13.9
SuperiorCervicalGanglion25.9
TemporalLobe13.85
Testis13.25
TestisGermCell12.85
TestisIntersitial24.5
TestisLeydigCell21.45
TestisSeminiferousTubule14.9
Thalamus15.45
Thymus12.3
Thyroid49.65
Tongue14.9
Tonsil19.5
Trachea12.85
TrigeminalGanglion22.55
Uterus29.4
UterusCorpus27.1
WholeBlood16.95
Wholebrain13.25
colon15.5
pineal_day19
pineal_night18.66
retina26.95
small_intestine15.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14244_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.16 ± 1.17
Basal Forebrain2.5 ± 0.56
Basal Part of Pons2.14 ± 1.01
Cerebellar Cortex2.51 ± 0.8
Cerebellar Nuclei2.81 ± 1.23
Claustrum3.41 ± 1.01
Epithalamus2.46 ± 0.46
Frontal Lobe2.45 ± 0.82
Globus Pallidus3.5 ± 0.81
Hypothalamus2.36 ± 0.9
Insula2.11 ± 0.73
Limbic Lobe2.65 ± 0.95
Mesencephalon2.97 ± 0.94
Myelencephalon2.66 ± 0.75
Occipital Lobe2.54 ± 0.82
Parietal Lobe2.66 ± 1.14
Pontine Tegmentum2.79 ± 0.92
Striatum3.07 ± 1.02
Subthalamus2.73 ± 1.28
Temporal Lobe2.52 ± 0.92
Thalamus2.64 ± 0.77
White Matter3.27 ± 0.53
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tcf3CBCerebellum34.03
38.58
Tcf3CTXCerebral cortex53.17
39.07
Tcf3HIPHippocampal region61.59
52.72
Tcf3HPFHippocampal formation58
47.55
Tcf3HYHypothalamus25.94
17.85
Tcf3LSXLateral septal complex24.37
14.01
Tcf3MBMidbrain32.78
28.64
Tcf3MYMedulla36.65
37.63
Tcf3OLFOlfactory bulb72.8
51.06
Tcf3PPons37.6
35
Tcf3PALPallidum26.65
23.42
Tcf3RHPRetrohippocampal region49.07
37.47
Tcf3sAMYStriatum-like amygdalar nuclei37.1
25.68
Tcf3STRStriatum34.97
23.79
Tcf3STRdStriatum dorsal region31.22
20.93
Tcf3STRvStriatum ventral region56.18
38.77
Tcf3THThalamus51.55
44.05
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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