AutismKB 2.0

Annotation Detail for HIST2H2BE


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Basic Information Top
Gene Symbol:HIST2H2BE ( GL105,H2B,H2B.1,H2BFQ,H2BGL105,H2BQ,MGC119802,MGC119804,MGC129733,MGC129734 )
Gene Full Name: histone cluster 2, H2be
Band: 1q21.2
Quick LinksEntrez ID:8349; OMIM: 601831; Uniprot ID:H2B2E_HUMAN; ENSEMBL ID: ENSG00000184678; HGNC ID: 4760
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus87 / 564012154
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult207 / 1939121106
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor28 / 94178297
cervical tumor4 / 34366116
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor6 / 17290347
gastrointestinal tumor5 / 11936941
germ cell tumor60 / 263845227
glioma10 / 10688393
head and neck tumor17 / 136302124
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor8 / 9635983
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal413 / 3360307122
ovarian tumor2 / 7668226
pancreatic tumor12 / 104616114
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer13 / 102680126
retinoblastoma4 / 4635686
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland6 / 33197180
ascites0 / 400150 
bladder2 / 2975767
blood5 / 12347840
bone2 / 7165527
bone marrow1 / 4880120
brain146 / 1100989132
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus6 / 20209296
eye20 / 21105494
heart15 / 89626167
intestine10 / 23447242
kidney18 / 21177784
larynx1 / 2414541
liver12 / 20774357
lung28 / 33697483
lymph1 / 4427022
lymph node4 / 9161043
mammary gland31 / 153271202
mouth16 / 67052238
muscle5 / 10771546
nerve3 / 15768190
ovary2 / 10205119
pancreas23 / 214812107
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland5 / 16585301
placenta39 / 280825138
prostate50 / 189345264
salivary gland0 / 201550 
skin15 / 21057471
spleen11 / 53952203
stomach9 / 9661993
testis14 / 33044242
thymus34 / 81131419
thyroid0 / 474730 
tonsil0 / 169990 
trachea8 / 52413152
umbilical cord0 / 136800 
uterus37 / 232878158
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202708_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.9
Adipocyte27.5
AdrenalCortex8.4
Adrenalgland26.25
Amygdala33.85
Appendix37.45
AtrioventricularNode15.85
BDCA4+_DentriticCells80.7
Bonemarrow118.4
BronchialEpithelialCells7.95
CD105+_Endothelial5
CD14+_Monocytes56.75
CD19+_BCells(neg._sel.)25.8
CD33+_Myeloid11.25
CD34+16.8
CD4+_Tcells21.9
CD56+_NKCells31.65
CD71+_EarlyErythroid5.85
CD8+_Tcells37
CardiacMyocytes7.05
Caudatenucleus34.7
Cerebellum66.05
CerebellumPeduncles38
CiliaryGanglion12.7
CingulateCortex15.25
Colorectaladenocarcinoma33.75
DorsalRootGanglion26.15
FetalThyroid43.7
Fetalbrain29
Fetalliver25.35
Fetallung133
GlobusPallidus10.35
Heart137.95
Hypothalamus44.35
Kidney14.85
Leukemia_chronicMyelogenousK-562172.85
Leukemia_promyelocytic-HL-606.45
Leukemialymphoblastic(MOLT-4)4.45
Liver10.3
Lung33.5
Lymphnode21.55
Lymphoma_burkitts(Daudi)10.55
Lymphoma_burkitts(Raji)7.65
MedullaOblongata29.75
OccipitalLobe18.7
OlfactoryBulb155.8
Ovary15.15
Pancreas6.1
PancreaticIslet22.65
ParietalLobe28.9
Pituitary119.25
Placenta198.3
Pons16.5
PrefrontalCortex38.6
Prostate405.3
Salivarygland35.1
SkeletalMuscle34.85
Skin26.25
SmoothMuscle6.15
Spinalcord46.25
SubthalamicNucleus13.1
SuperiorCervicalGanglion52.2
TemporalLobe15
Testis21
TestisGermCell23.05
TestisIntersitial7.8
TestisLeydigCell14.8
TestisSeminiferousTubule13.8
Thalamus23.55
Thymus52.35
Thyroid31.6
Tongue31.25
Tonsil11.1
Trachea27.1
TrigeminalGanglion39.95
Uterus24.85
UterusCorpus22.25
WholeBlood137.6
Wholebrain22.7
colon6.6
pineal_day976.38
pineal_night1013.02
retina90.725
small_intestine6.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P156911
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.35 ± 0.78
Basal Forebrain7.63 ± 0.26
Basal Part of Pons7.36 ± 0.49
Cerebellar Cortex7.68 ± 0.32
Cerebellar Nuclei7.71 ± 0.34
Claustrum7.54 ± 0.47
Epithalamus7.77 ± 0.39
Frontal Lobe7.37 ± 0.41
Globus Pallidus7.86 ± 0.43
Hypothalamus7.51 ± 0.45
Insula7.32 ± 0.26
Limbic Lobe7.45 ± 0.25
Mesencephalon7.38 ± 0.4
Myelencephalon7.44 ± 0.36
Occipital Lobe7.27 ± 0.33
Parietal Lobe7.35 ± 0.33
Pontine Tegmentum7.41 ± 0.32
Striatum7.6 ± 0.44
Subthalamus7.06 ± 0.33
Temporal Lobe7.37 ± 0.31
Thalamus7.34 ± 0.33
White Matter8.05 ± 0.33
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000587 15 59 73 AMGIMNSFVNDIFER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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