AutismKB 2.0

Annotation Detail for CASP2


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Basic Information Top
Gene Symbol:CASP2 ( CASP-2,ICH-1L,ICH-1L/1S,ICH1,NEDD2 )
Gene Full Name: caspase 2, apoptosis-related cysteine peptidase
Band: 7q34
Quick LinksEntrez ID:835; OMIM: 600639; Uniprot ID:CASP2_HUMAN; ENSEMBL ID: ENSG00000106144; HGNC ID: 1503
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus27 / 56401247
neonate1 / 3109732
infant1 / 2362042
juvenile3 / 5555653
adult69 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor14 / 26384553
glioma2 / 10688318
head and neck tumor8 / 13630258
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma8 / 71755111
non-neoplasia0 / 972500 
normal343 / 3360307102
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood3 / 12347824
bone3 / 7165541
bone marrow1 / 4880120
brain29 / 110098926
cervix1 / 4817120
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye7 / 21105433
heart4 / 8962644
intestine3 / 23447212
kidney2 / 2117779
larynx4 / 24145165
liver2 / 2077439
lung2 / 3369745
lymph0 / 442700 
lymph node15 / 91610163
mammary gland8 / 15327152
mouth4 / 6705259
muscle2 / 10771518
nerve0 / 157680 
ovary4 / 10205139
pancreas1 / 2148124
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate6 / 18934531
salivary gland0 / 201550 
skin13 / 21057461
spleen1 / 5395218
stomach0 / 966190 
testis14 / 33044242
thymus13 / 81131160
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus8 / 23287834
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209811_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte5.05
AdrenalCortex6.15
Adrenalgland4.55
Amygdala5.4
Appendix7.15
AtrioventricularNode4.95
BDCA4+_DentriticCells6.25
Bonemarrow6.85
BronchialEpithelialCells5.1
CD105+_Endothelial5.25
CD14+_Monocytes5.45
CD19+_BCells(neg._sel.)5.5
CD33+_Myeloid6.95
CD34+6.65
CD4+_Tcells5.65
CD56+_NKCells6.15
CD71+_EarlyErythroid4.9
CD8+_Tcells5
CardiacMyocytes8.45
Caudatenucleus4.65
Cerebellum4.3
CerebellumPeduncles5.9
CiliaryGanglion4.35
CingulateCortex5.35
Colorectaladenocarcinoma5.35
DorsalRootGanglion4.65
FetalThyroid5.05
Fetalbrain5.15
Fetalliver4.85
Fetallung4.3
GlobusPallidus3.95
Heart8.3
Hypothalamus5.65
Kidney4.8
Leukemia_chronicMyelogenousK-5624.7
Leukemia_promyelocytic-HL-604.6
Leukemialymphoblastic(MOLT-4)20.45
Liver7.15
Lung5.7
Lymphnode4.65
Lymphoma_burkitts(Daudi)6.8
Lymphoma_burkitts(Raji)7.45
MedullaOblongata4.65
OccipitalLobe4.65
OlfactoryBulb4.1
Ovary3.85
Pancreas4.25
PancreaticIslet5.6
ParietalLobe5.75
Pituitary6.05
Placenta5.3
Pons5
PrefrontalCortex6.25
Prostate6.05
Salivarygland4.25
SkeletalMuscle7.9
Skin4.15
SmoothMuscle5.85
Spinalcord5.55
SubthalamicNucleus4.75
SuperiorCervicalGanglion8.95
TemporalLobe4.75
Testis4.4
TestisGermCell4.25
TestisIntersitial4.35
TestisLeydigCell5.25
TestisSeminiferousTubule4.45
Thalamus5.3
Thymus14.8
Thyroid6.6
Tongue5.2
Tonsil5.1
Trachea4.5
TrigeminalGanglion5.35
Uterus4.2
UterusCorpus4.85
WholeBlood5.65
Wholebrain4.35
colon5.15
pineal_day6.46
pineal_night6.28
retina6.25
small_intestine4.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P215701
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2 ± 1.13
Basal Forebrain1.56 ± 0.22
Basal Part of Pons1.27 ± 0.32
Cerebellar Cortex1.64 ± 0.84
Cerebellar Nuclei1.75 ± 0.74
Claustrum2.46 ± 1.15
Epithalamus1.33 ± 0.86
Frontal Lobe1.41 ± 0.76
Globus Pallidus2.05 ± 0.85
Hypothalamus1.56 ± 0.72
Insula1.48 ± 0.81
Limbic Lobe1.5 ± 0.68
Mesencephalon1.64 ± 0.73
Myelencephalon1.53 ± 0.73
Occipital Lobe1.72 ± 0.64
Parietal Lobe1.5 ± 0.85
Pontine Tegmentum1.7 ± 0.96
Striatum1.61 ± 0.58
Subthalamus1.63 ± 0.69
Temporal Lobe1.44 ± 0.85
Thalamus1.47 ± 0.62
White Matter1.96 ± 0.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Casp2CBCerebellum0.92
1.37
Casp2CTXCerebral cortex0.53
0.82
Casp2HIPHippocampal region0.69
0.99
Casp2HPFHippocampal formation0.55
0.75
Casp2HYHypothalamus0.25
0.26
Casp2LSXLateral septal complex0.93
1.05
Casp2MBMidbrain0.6
1.15
Casp2MYMedulla0.75
1.16
Casp2OLFOlfactory bulb4.38
5.13
Casp2PPons1.21
1.76
Casp2PALPallidum0.17
0.31
Casp2RHPRetrohippocampal region0.33
0.46
Casp2sAMYStriatum-like amygdalar nuclei0.27
0.3
Casp2STRStriatum0.33
0.38
Casp2STRdStriatum dorsal region0.16
0.18
Casp2STRvStriatum ventral region0.51
0.49
Casp2THThalamus0.37
1.32
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00031888 24 266 289 VTDSCIVALLSHGVEGAIYGVDGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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