AutismKB 2.0

Annotation Detail for COG3


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Basic Information Top
Gene Symbol:COG3 ( SEC34 )
Gene Full Name: component of oligomeric golgi complex 3
Band: 13q14.13
Quick LinksEntrez ID:83548; OMIM: 606975; Uniprot ID:COG3_HUMAN; ENSEMBL ID: ENSG00000136152; HGNC ID: 18619
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst3 / 6231948
fetus32 / 56401256
neonate1 / 3109732
infant4 / 23620169
juvenile2 / 5555635
adult86 / 193912144
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor5 / 11424643
esophageal tumor3 / 17290173
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia5 / 9725051
normal187 / 336030755
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor9 / 9025799
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone3 / 7165541
bone marrow2 / 4880140
brain59 / 110098953
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus3 / 20209148
eye5 / 21105423
heart5 / 8962655
intestine10 / 23447242
kidney4 / 21177718
larynx1 / 2414541
liver4 / 20774319
lung20 / 33697459
lymph0 / 442700 
lymph node7 / 9161076
mammary gland8 / 15327152
mouth4 / 6705259
muscle4 / 10771537
nerve2 / 15768126
ovary2 / 10205119
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta13 / 28082546
prostate12 / 18934563
salivary gland0 / 201550 
skin14 / 21057466
spleen1 / 5395218
stomach1 / 9661910
testis27 / 33044281
thymus7 / 8113186
thyroid0 / 474730 
tonsil0 / 169990 
trachea17 / 52413324
umbilical cord0 / 136800 
uterus14 / 23287860
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P212819
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.91 ± 0.8
Basal Forebrain9.5 ± 0.23
Basal Part of Pons10.03 ± 0.34
Cerebellar Cortex9.31 ± 0.48
Cerebellar Nuclei9.88 ± 0.37
Claustrum9.98 ± 0.45
Epithalamus9.45 ± 0.64
Frontal Lobe9.82 ± 0.55
Globus Pallidus10.25 ± 0.27
Hypothalamus9.55 ± 0.83
Insula9.62 ± 0.69
Limbic Lobe9.77 ± 0.45
Mesencephalon9.61 ± 0.45
Myelencephalon9.74 ± 0.57
Occipital Lobe9.53 ± 0.55
Parietal Lobe9.6 ± 0.52
Pontine Tegmentum9.59 ± 0.55
Striatum9.92 ± 0.62
Subthalamus9.52 ± 0.04
Temporal Lobe9.66 ± 0.57
Thalamus9.68 ± 0.48
White Matter10.21 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cog3CBCerebellum19.7
19.34
Cog3CTXCerebral cortex54
37.17
Cog3HIPHippocampal region37.86
41.21
Cog3HPFHippocampal formation39.59
36.98
Cog3HYHypothalamus12.99
9.19
Cog3LSXLateral septal complex29.04
18.13
Cog3MBMidbrain15.04
12.47
Cog3MYMedulla21.39
20.36
Cog3OLFOlfactory bulb44.29
33.56
Cog3PPons17.33
16.15
Cog3PALPallidum15.2
11.6
Cog3RHPRetrohippocampal region44.12
32.13
Cog3sAMYStriatum-like amygdalar nuclei13.19
8.4
Cog3STRStriatum21.19
13.72
Cog3STRdStriatum dorsal region21.07
14.06
Cog3STRvStriatum ventral region23
13.61
Cog3THThalamus24.72
19.16
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
COG3_HUMAN_1 15 1 15 AEAALLLLPEAAAER PRIDE
COG3_HUMAN_2 15 2 16 AEAALLLLPEAAAER PRIDE
PAp00028094 28 169 196 TGTLHEACEQLLKEQSELVDLAENIQQK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018