AutismKB 2.0

Annotation Detail for TLN2


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Basic Information Top
Gene Symbol:TLN2 ( DKFZp451B1011,DKFZp686I0976,DKFZp686K0979,ILWEQ,KIAA0320 )
Gene Full Name: talin 2
Band: 15q22.2
Quick LinksEntrez ID:83660; OMIM: 607349; Uniprot ID:TLN2_HUMAN; ENSEMBL ID: ENSG00000171914; HGNC ID: 15447
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst3 / 6231948
fetus49 / 56401286
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult69 / 193912135
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult2 / 19391211
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor3 / 26384511
glioma6 / 10688356
head and neck tumor2 / 13630214
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia6 / 9725061
normal164 / 336030748
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma4 / 4635686
skin tumor2 / 12494916
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal3 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood1 / 1234788
bone4 / 7165555
bone marrow0 / 488010 
brain79 / 110098971
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye19 / 21105490
heart7 / 8962678
intestine9 / 23447238
kidney15 / 21177770
larynx0 / 241450 
liver5 / 20774324
lung1 / 3369742
lymph1 / 4427022
lymph node4 / 9161043
mammary gland6 / 15327139
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas1 / 2148124
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta1 / 2808253
prostate1 / 1893455
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach3 / 9661931
testis7 / 33044221
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212703_at
Cell line Expression level Expression bar
721_B_lymphoblasts30.2
Adipocyte47.4
AdrenalCortex23.95
Adrenalgland25.85
Amygdala19.7
Appendix19.35
AtrioventricularNode34.65
BDCA4+_DentriticCells16.85
Bonemarrow39.5
BronchialEpithelialCells10.25
CD105+_Endothelial25.35
CD14+_Monocytes10.4
CD19+_BCells(neg._sel.)6.4
CD33+_Myeloid14.05
CD34+13.65
CD4+_Tcells5.6
CD56+_NKCells10.85
CD71+_EarlyErythroid144
CD8+_Tcells5.2
CardiacMyocytes18.6
Caudatenucleus45.25
Cerebellum28.25
CerebellumPeduncles56.75
CiliaryGanglion51.3
CingulateCortex64.85
Colorectaladenocarcinoma7.25
DorsalRootGanglion31.15
FetalThyroid22.5
Fetalbrain26.85
Fetalliver17.45
Fetallung16.25
GlobusPallidus66.1
Heart25.05
Hypothalamus54.4
Kidney159.85
Leukemia_chronicMyelogenousK-56226.35
Leukemia_promyelocytic-HL-6013.25
Leukemialymphoblastic(MOLT-4)25.7
Liver28.65
Lung7.1
Lymphnode16.8
Lymphoma_burkitts(Daudi)31.2
Lymphoma_burkitts(Raji)19.3
MedullaOblongata40.1
OccipitalLobe66.8
OlfactoryBulb17.1
Ovary7.55
Pancreas22.8
PancreaticIslet20.9
ParietalLobe67.1
Pituitary29.1
Placenta12.3
Pons56.95
PrefrontalCortex56.5
Prostate18
Salivarygland16.7
SkeletalMuscle50.05
Skin26.2
SmoothMuscle18.7
Spinalcord55.35
SubthalamicNucleus65.9
SuperiorCervicalGanglion27.85
TemporalLobe78.05
Testis19.05
TestisGermCell17.85
TestisIntersitial21.25
TestisLeydigCell26.65
TestisSeminiferousTubule33.55
Thalamus78
Thymus8.1
Thyroid16.1
Tongue36.15
Tonsil24.25
Trachea18.85
TrigeminalGanglion30.6
Uterus12.15
UterusCorpus20.35
WholeBlood5.55
Wholebrain37
colon19.3
pineal_day104.58
pineal_night111.5
retina24.575
small_intestine7.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P170406
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.89 ± 0.24
Basal Forebrain10.58 ± 0.26
Basal Part of Pons10.45 ± 0.23
Cerebellar Cortex10.19 ± 0.14
Cerebellar Nuclei10.17 ± 0.22
Claustrum10.76 ± 0.17
Epithalamus10.49 ± 0.53
Frontal Lobe10.53 ± 0.36
Globus Pallidus9.81 ± 0.63
Hypothalamus10.16 ± 0.3
Insula10.62 ± 0.26
Limbic Lobe10.74 ± 0.32
Mesencephalon10.37 ± 0.36
Myelencephalon10.49 ± 0.39
Occipital Lobe10.43 ± 0.35
Parietal Lobe10.56 ± 0.34
Pontine Tegmentum10.55 ± 0.27
Striatum10.56 ± 0.38
Subthalamus10.6 ± 0.38
Temporal Lobe10.7 ± 0.25
Thalamus10.34 ± 0.31
White Matter9.59 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tln2CBCerebellum13.25
14.92
Tln2CTXCerebral cortex11.12
8.27
Tln2HIPHippocampal region11.83
11.88
Tln2HPFHippocampal formation9.86
9.17
Tln2HYHypothalamus3.45
2.8
Tln2LSXLateral septal complex3.14
2.74
Tln2MBMidbrain8.39
8.41
Tln2MYMedulla13.68
16.4
Tln2OLFOlfactory bulb26.13
22.35
Tln2PPons7.74
9.25
Tln2PALPallidum9.33
9.21
Tln2RHPRetrohippocampal region6.89
5.56
Tln2sAMYStriatum-like amygdalar nuclei3.39
2.73
Tln2STRStriatum9.61
7.21
Tln2STRdStriatum dorsal region7.87
5.78
Tln2STRvStriatum ventral region23.7
16.78
Tln2THThalamus46.45
44.77
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00000745 9 2190 2198 AVAAGNSCR Peptide Atlas
TLN2_HUMAN_0 0 0 0 DPVQLNLLYVQAR PRIDE
TLN2_HUMAN_0 0 0 0 EVANSTANLVK PRIDE
TLN2_HUMAN_0 0 0 0 LREAAEGLR PRIDE
TLN2_HUMAN_0 0 0 0 SIAAATSALVK PRIDE
TLN2_HUMAN_0 0 0 0 TYGVSFFLVK PRIDE
TLN2_HUMAN_0 0 0 0 VMVTNVTSLLK PRIDE
TLN2_HUMAN_1532 11 1532 1542 EVANSTANLVK PRIDE
TLN2_HUMAN_1732 21 1732 1752 VTQLASYFEPLILAAVGVASK PRIDE
TLN2_HUMAN_196 13 196 208 RKFFYSDQNVDSR PRIDE
TLN2_HUMAN_197 25 197 221 KFFYSDQNVDSRDPVQLNLLYVQAR PRIDE
TLN2_HUMAN_198 24 198 221 FFYSDQNVDSRDPVQLNLLYVQAR PRIDE
TLN2_HUMAN_209 13 209 221 DPVQLNLLYVQAR PRIDE
TLN2_HUMAN_2120 11 2120 2130 VMVTNVTSLLK PRIDE
TLN2_HUMAN_2198 12 2198 2209 QEDVIATANLSR PRIDE
TLN2_HUMAN_2351 11 2351 2361 SIAAATSALVK PRIDE
TLN2_HUMAN_2430 14 2430 2443 QVAASTAQLLVACK PRIDE
TLN2_HUMAN_309 10 309 318 TYGVSFFLVK PRIDE
TLN2_HUMAN_309 12 309 320 TYGVSFFLVKEK PRIDE
TLN2_HUMAN_445 13 445 457 AEHGSVALPAVMR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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