AutismKB 2.0

Annotation Detail for CASP7


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Basic Information Top
Gene Symbol:CASP7 ( CMH-1,ICE-LAP3,MCH3 )
Gene Full Name: caspase 7, apoptosis-related cysteine peptidase
Band: 10q25.3
Quick LinksEntrez ID:840; OMIM: 601761; Uniprot ID:CASP7_HUMAN; ENSEMBL ID: ENSG00000165806; HGNC ID: 1508
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus17 / 56401230
neonate3 / 3109796
infant0 / 236200 
juvenile9 / 55556161
adult91 / 193912146
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor16 / 26384560
glioma7 / 10688365
head and neck tumor9 / 13630266
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor3 / 10312729
lymphoma3 / 7175541
non-neoplasia8 / 9725082
normal166 / 336030749
ovarian tumor5 / 7668265
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer4 / 10268038
retinoblastoma3 / 4635664
skin tumor3 / 12494924
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites1 / 4001524
bladder7 / 29757235
blood4 / 12347832
bone4 / 7165555
bone marrow2 / 4880140
brain47 / 110098942
cervix2 / 4817141
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye5 / 21105423
heart5 / 8962655
intestine15 / 23447263
kidney18 / 21177784
larynx0 / 241450 
liver7 / 20774333
lung19 / 33697456
lymph1 / 4427022
lymph node1 / 9161010
mammary gland3 / 15327119
mouth9 / 67052134
muscle3 / 10771527
nerve2 / 15768126
ovary3 / 10205129
pancreas2 / 2148129
parathyroid2 / 2053997
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta12 / 28082542
prostate14 / 18934573
salivary gland0 / 201550 
skin17 / 21057480
spleen7 / 53952129
stomach8 / 9661982
testis11 / 33044233
thymus9 / 81131110
thyroid0 / 474730 
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus13 / 23287855
vascular23 / 51780444
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207181_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts27.7
Adipocyte10.4
AdrenalCortex12.05
Adrenalgland9.35
Amygdala9.65
Appendix11.65
AtrioventricularNode10.45
BDCA4+_DentriticCells15.15
Bonemarrow10.9
BronchialEpithelialCells16.9
CD105+_Endothelial8.55
CD14+_Monocytes14.2
CD19+_BCells(neg._sel.)19.7
CD33+_Myeloid16.85
CD34+13
CD4+_Tcells16.9
CD56+_NKCells17.3
CD71+_EarlyErythroid9.3
CD8+_Tcells19.5
CardiacMyocytes16.85
Caudatenucleus7.2
Cerebellum7.3
CerebellumPeduncles10.75
CiliaryGanglion11.7
CingulateCortex9.15
Colorectaladenocarcinoma10.65
DorsalRootGanglion12
FetalThyroid10.75
Fetalbrain9.45
Fetalliver9.6
Fetallung21.85
GlobusPallidus7.5
Heart15.4
Hypothalamus12
Kidney9.8
Leukemia_chronicMyelogenousK-5629.5
Leukemia_promyelocytic-HL-6017.1
Leukemialymphoblastic(MOLT-4)8.95
Liver17.5
Lung46.8
Lymphnode13.1
Lymphoma_burkitts(Daudi)20.9
Lymphoma_burkitts(Raji)20.1
MedullaOblongata9.15
OccipitalLobe7.15
OlfactoryBulb8.8
Ovary7
Pancreas10.15
PancreaticIslet20
ParietalLobe10.55
Pituitary12.35
Placenta16.65
Pons8.55
PrefrontalCortex13.5
Prostate56.6
Salivarygland16.2
SkeletalMuscle15.95
Skin9.85
SmoothMuscle19.45
Spinalcord10.65
SubthalamicNucleus9.2
SuperiorCervicalGanglion14.95
TemporalLobe8.75
Testis9.3
TestisGermCell8.35
TestisIntersitial8.45
TestisLeydigCell9.85
TestisSeminiferousTubule7.9
Thalamus8.8
Thymus14.35
Thyroid31.8
Tongue11.05
Tonsil10.8
Trachea13.5
TrigeminalGanglion12.55
Uterus30.1
UterusCorpus10.05
WholeBlood17.4
Wholebrain8.35
colon559.7
pineal_day11.26
pineal_night11.56
retina16.875
small_intestine214.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15259_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.25 ± 0.79
Basal Forebrain3.11 ± 0.51
Basal Part of Pons2.33 ± 0.48
Cerebellar Cortex2.5 ± 0.77
Cerebellar Nuclei2.82 ± 0.74
Claustrum3.32 ± 0.46
Epithalamus3.22 ± 0.63
Frontal Lobe2.74 ± 0.71
Globus Pallidus3.76 ± 0.71
Hypothalamus2.58 ± 0.58
Insula2.47 ± 0.76
Limbic Lobe2.7 ± 0.8
Mesencephalon3.11 ± 0.9
Myelencephalon2.91 ± 0.71
Occipital Lobe3.02 ± 0.86
Parietal Lobe2.81 ± 0.82
Pontine Tegmentum2.85 ± 0.7
Striatum3.29 ± 0.72
Subthalamus2.76 ± 0.77
Temporal Lobe2.71 ± 0.65
Thalamus2.87 ± 0.68
White Matter2.84 ± 0.75
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Casp7CBCerebellum0
0
Casp7CTXCerebral cortex0
0
Casp7HIPHippocampal region0
0
Casp7HPFHippocampal formation0
0
Casp7HYHypothalamus0
0
Casp7LSXLateral septal complex0
0
Casp7MBMidbrain0
0
Casp7MYMedulla0
0
Casp7OLFOlfactory bulb0
0
Casp7PPons0
0
Casp7PALPallidum0
0
Casp7RHPRetrohippocampal region0
0
Casp7sAMYStriatum-like amygdalar nuclei0
0
Casp7STRStriatum0
0
Casp7STRdStriatum dorsal region0
0
Casp7STRvStriatum ventral region0
0
Casp7THThalamus0
0
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CASP7_HUMAN_2 27 2 28 ADDQGCIEEQGVEDSANEDSVDAKPDR PRIDE
PAp00095412 28 159 186 ASEEDHTNAACFACILLSHGEENVIYGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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