AutismKB 2.0

Annotation Detail for TAGLN2


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Basic Information Top
Gene Symbol:TAGLN2 ( HA1756,KIAA0120 )
Gene Full Name: transgelin 2
Band: 1q23.2
Quick LinksEntrez ID:8407; OMIM: 604634; Uniprot ID:TAGL2_HUMAN; ENSEMBL ID: ENSG00000158710; HGNC ID: 11554
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body37 / 70761522
blastocyst11 / 62319176
fetus33 / 56401258
neonate0 / 310970 
infant0 / 236200 
juvenile9 / 55556161
adult452 / 1939121233
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma5 / 17475286
breast (mammary gland) tumor39 / 94178414
cervical tumor22 / 34366640
chondrosarcoma24 / 82823289
colorectal tumor30 / 114246262
esophageal tumor4 / 17290231
gastrointestinal tumor32 / 119369268
germ cell tumor50 / 263845189
glioma31 / 106883290
head and neck tumor30 / 136302220
kidney tumor35 / 68959507
leukemia23 / 95842239
liver tumor16 / 96359166
lung tumor60 / 103127581
lymphoma57 / 71755794
non-neoplasia9 / 9725092
normal600 / 3360307178
ovarian tumor33 / 76682430
pancreatic tumor68 / 104616649
primitive neuroectodermal tumor of the CNS36 / 125680286
prostate cancer56 / 102680545
retinoblastoma0 / 463560 
skin tumor115 / 124949920
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor67 / 90257742
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue64 / 131064883
adrenal gland6 / 33197180
ascites7 / 40015174
bladder6 / 29757201
blood43 / 123478348
bone26 / 71655362
bone marrow9 / 48801184
brain83 / 110098975
cervix29 / 48171602
connective tissue15 / 149255100
ear0 / 162120 
embryonic tissue57 / 215722264
esophagus4 / 20209197
eye44 / 211054208
heart11 / 89626122
intestine51 / 234472217
kidney40 / 211777188
larynx9 / 24145372
liver24 / 207743115
lung97 / 336974287
lymph46 / 442701039
lymph node19 / 91610207
mammary gland63 / 153271411
mouth1 / 6705214
muscle3 / 10771527
nerve6 / 15768380
ovary44 / 102051431
pancreas76 / 214812353
parathyroid0 / 205390 
pharynx10 / 41328241
pituitary gland1 / 1658560
placenta139 / 280825494
prostate62 / 189345327
salivary gland12 / 20155595
skin132 / 210574626
spleen19 / 53952352
stomach25 / 96619258
testis26 / 33044278
thymus3 / 8113136
thyroid5 / 47473105
tonsil20 / 169991176
trachea0 / 524130 
umbilical cord0 / 136800 
uterus92 / 232878395
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210978_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1963.6
Adipocyte192.65
AdrenalCortex82.1
Adrenalgland123.6
Amygdala75.4
Appendix111.25
AtrioventricularNode53.6
BDCA4+_DentriticCells2977.7
Bonemarrow270.05
BronchialEpithelialCells1730.3
CD105+_Endothelial225.1
CD14+_Monocytes1842.5
CD19+_BCells(neg._sel.)1831.75
CD33+_Myeloid964.05
CD34+1404.05
CD4+_Tcells749.1
CD56+_NKCells1116.3
CD71+_EarlyErythroid96.35
CD8+_Tcells471.05
CardiacMyocytes1374.45
Caudatenucleus66.7
Cerebellum49.75
CerebellumPeduncles70.7
CiliaryGanglion69.25
CingulateCortex70.4
Colorectaladenocarcinoma300.65
DorsalRootGanglion81.3
FetalThyroid106.25
Fetalbrain58.8
Fetalliver81
Fetallung240.15
GlobusPallidus47.3
Heart599.45
Hypothalamus43.3
Kidney86
Leukemia_chronicMyelogenousK-562242.65
Leukemia_promyelocytic-HL-60220.3
Leukemialymphoblastic(MOLT-4)53.4
Liver394.6
Lung1275.15
Lymphnode126.9
Lymphoma_burkitts(Daudi)137.55
Lymphoma_burkitts(Raji)246.75
MedullaOblongata53.9
OccipitalLobe48.5
OlfactoryBulb94.6
Ovary154.45
Pancreas87.2
PancreaticIslet358.95
ParietalLobe70.35
Pituitary115.8
Placenta754.7
Pons88.6
PrefrontalCortex87.55
Prostate203.95
Salivarygland47.5
SkeletalMuscle66.2
Skin71.5
SmoothMuscle962.4
Spinalcord60.45
SubthalamicNucleus45.1
SuperiorCervicalGanglion140.95
TemporalLobe64.5
Testis121
TestisGermCell176.1
TestisIntersitial91.45
TestisLeydigCell94.8
TestisSeminiferousTubule109.5
Thalamus61.85
Thymus392.8
Thyroid154.2
Tongue118
Tonsil346.55
Trachea238.4
TrigeminalGanglion102.95
Uterus232.55
UterusCorpus101.35
WholeBlood3956.85
Wholebrain69.55
colon210.45
pineal_day170.66
pineal_night172.96
retina266.3
small_intestine246.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P194848
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.84 ± 0.88
Basal Forebrain2.62 ± 0.43
Basal Part of Pons2.77 ± 0.61
Cerebellar Cortex2.58 ± 0.63
Cerebellar Nuclei3.21 ± 0.68
Claustrum3.94 ± 0.74
Epithalamus3.43 ± 1.01
Frontal Lobe2.89 ± 0.82
Globus Pallidus3.61 ± 0.74
Hypothalamus3.11 ± 0.89
Insula3.15 ± 0.73
Limbic Lobe2.82 ± 0.72
Mesencephalon3.04 ± 0.81
Myelencephalon3 ± 0.77
Occipital Lobe2.78 ± 0.69
Parietal Lobe2.71 ± 0.77
Pontine Tegmentum3.14 ± 0.69
Striatum3.3 ± 0.73
Subthalamus2.38 ± 0.7
Temporal Lobe2.93 ± 0.77
Thalamus2.88 ± 0.62
White Matter3.19 ± 0.23
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tagln2CBCerebellum0.08
0.12
Tagln2CTXCerebral cortex0.13
0.18
Tagln2HIPHippocampal region0.17
0.18
Tagln2HPFHippocampal formation0.14
0.18
Tagln2HYHypothalamus0.01
0.11
Tagln2LSXLateral septal complex0
0
Tagln2MBMidbrain0.31
0.46
Tagln2MYMedulla0.5
0.92
Tagln2OLFOlfactory bulb0.07
0.1
Tagln2PPons0.13
0.21
Tagln2PALPallidum0.02
0.02
Tagln2RHPRetrohippocampal region0.09
0.2
Tagln2sAMYStriatum-like amygdalar nuclei0.12
0.12
Tagln2STRStriatum0.34
0.44
Tagln2STRdStriatum dorsal region0.54
0.71
Tagln2STRvStriatum ventral region0.05
0.04
Tagln2THThalamus0.09
0.09
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001618 21 58 78 DGTVLCELINALYPEGQAPVK Peptide Atlas
TAGL2_HUMAN_0 0 0 0 NFSDNQLQEGK PRIDE
TAGL2_HUMAN_1 11 1 11 ANRGPAYGLSR PRIDE
TAGL2_HUMAN_102 18 102 119 YGINTTDIFQTVDLWEGK PRIDE
TAGL2_HUMAN_120 7 120 126 NMACVQR PRIDE
TAGL2_HUMAN_127 12 127 138 TLMNLGGLAVAR PRIDE
TAGL2_HUMAN_127 26 127 152 TLMNLGGLAVARDDGLFSGDPNWFPK PRIDE
TAGL2_HUMAN_127 27 127 153 TLMNLGGLAVARDDGLFSGDPNWFPKK PRIDE
TAGL2_HUMAN_128 11 128 138 LMNLGGLAVAR PRIDE
TAGL2_HUMAN_128 12 128 139 TLMNLGGLAVAR PRIDE
TAGL2_HUMAN_139 14 139 152 DDGLFSGDPNWFPK PRIDE
TAGL2_HUMAN_139 15 139 153 DDGLFSGDPNWFPKK PRIDE
TAGL2_HUMAN_151 10 151 160 FPKKSKENPR PRIDE
TAGL2_HUMAN_156 15 156 170 ENPRNFSDNQLQEGK PRIDE
TAGL2_HUMAN_160 11 160 170 NFSDNQLQEGK PRIDE
TAGL2_HUMAN_160 22 160 181 NFSDNQLQEGKNVIGLQMGTNR PRIDE
TAGL2_HUMAN_17 22 17 38 IEKQYDADLEQILIQWITTQCR PRIDE
TAGL2_HUMAN_17 23 17 39 IEKQYDADLEQILIQWITTQCRK PRIDE
TAGL2_HUMAN_171 11 171 181 NVIGLQMGTNR PRIDE
TAGL2_HUMAN_172 11 172 182 NVIGLQMGTNR PRIDE
TAGL2_HUMAN_182 14 182 195 GASQAGMTGYGMPR PRIDE
TAGL2_HUMAN_183 13 183 195 ASQAGMTGYGMPR PRIDE
TAGL2_HUMAN_20 19 20 38 QYDADLEQILIQWITTQCR PRIDE
TAGL2_HUMAN_20 20 20 39 QYDADLEQILIQWITTQCRK PRIDE
TAGL2_HUMAN_39 18 39 56 KDVGRPQPGRENFQNWLK PRIDE
TAGL2_HUMAN_4 8 4 11 GPAYGLSR PRIDE
TAGL2_HUMAN_40 17 40 56 DVGRPQPGRENFQNWLK PRIDE
TAGL2_HUMAN_49 8 49 56 ENFQNWLK PRIDE
TAGL2_HUMAN_57 21 57 77 DGTVLCELINALYPEGQAPVK PRIDE
TAGL2_HUMAN_57 22 57 78 DGTVLCELINALYPEGQAPVKK PRIDE
TAGL2_HUMAN_78 10 78 87 KIQASTMAFK PRIDE
TAGL2_HUMAN_79 23 79 101 IQASTMAFKQMEQISQFLQAAER PRIDE
TAGL2_HUMAN_79 9 79 87 IQASTMAFK PRIDE
TAGL2_HUMAN_80 9 80 88 IQASTMAFK PRIDE
TAGL2_HUMAN_88 14 88 101 QMEQISQFLQAAER PRIDE
TAGL2_HUMAN_89 14 89 102 QMEQISQFLQAAER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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