AutismKB 2.0

Annotation Detail for BCAR3


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Basic Information Top
Gene Symbol:BCAR3 ( KIAA0554,NSP2,SH2D3B )
Gene Full Name: breast cancer anti-estrogen resistance 3
Band: 1p22.1
Quick LinksEntrez ID:8412; OMIM: 604704; Uniprot ID:BCAR3_HUMAN; ENSEMBL ID: ENSG00000137936; HGNC ID: 973
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst2 / 6231932
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult89 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor6 / 9635962
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal135 / 336030740
ovarian tumor4 / 7668252
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood2 / 12347816
bone4 / 7165555
bone marrow0 / 488010 
brain24 / 110098921
cervix2 / 4817141
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine17 / 23447272
kidney13 / 21177761
larynx1 / 2414541
liver9 / 20774343
lung13 / 33697438
lymph0 / 442700 
lymph node9 / 9161098
mammary gland11 / 15327171
mouth5 / 6705274
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta29 / 280825103
prostate1 / 1893455
salivary gland1 / 2015549
skin5 / 21057423
spleen1 / 5395218
stomach3 / 9661931
testis8 / 33044224
thymus1 / 8113112
thyroid4 / 4747384
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204032_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.7
Adipocyte14.15
AdrenalCortex15.7
Adrenalgland20.35
Amygdala10.75
Appendix15.75
AtrioventricularNode14.2
BDCA4+_DentriticCells10.35
Bonemarrow13.35
BronchialEpithelialCells98.85
CD105+_Endothelial9.8
CD14+_Monocytes10.45
CD19+_BCells(neg._sel.)11.2
CD33+_Myeloid10.85
CD34+10.75
CD4+_Tcells10.2
CD56+_NKCells10.5
CD71+_EarlyErythroid10.5
CD8+_Tcells9.2
CardiacMyocytes34.6
Caudatenucleus9.6
Cerebellum10.35
CerebellumPeduncles14.4
CiliaryGanglion12.95
CingulateCortex13.5
Colorectaladenocarcinoma117.35
DorsalRootGanglion11.3
FetalThyroid10.8
Fetalbrain9.35
Fetalliver9.6
Fetallung9.15
GlobusPallidus9
Heart24.25
Hypothalamus10.6
Kidney14.6
Leukemia_chronicMyelogenousK-5629.5
Leukemia_promyelocytic-HL-609.4
Leukemialymphoblastic(MOLT-4)8.1
Liver19.8
Lung39.2
Lymphnode11.5
Lymphoma_burkitts(Daudi)14.4
Lymphoma_burkitts(Raji)16.85
MedullaOblongata9.85
OccipitalLobe9.1
OlfactoryBulb11.45
Ovary8.9
Pancreas10.15
PancreaticIslet11.35
ParietalLobe11.7
Pituitary12.6
Placenta156.65
Pons11
PrefrontalCortex12.75
Prostate13.2
Salivarygland13.55
SkeletalMuscle16.2
Skin10.15
SmoothMuscle46.4
Spinalcord20.15
SubthalamicNucleus9.85
SuperiorCervicalGanglion21.65
TemporalLobe10.8
Testis15.1
TestisGermCell9.25
TestisIntersitial13.85
TestisLeydigCell14.2
TestisSeminiferousTubule10.65
Thalamus10.7
Thymus8.3
Thyroid13.9
Tongue13
Tonsil12.6
Trachea14.25
TrigeminalGanglion14.5
Uterus8.5
UterusCorpus12.9
WholeBlood10.65
Wholebrain10.8
colon18.7
pineal_day13.1
pineal_night12.72
retina19.15
small_intestine11.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7581_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.96 ± 0.43
Basal Forebrain5.34 ± 0.37
Basal Part of Pons4.29 ± 0.6
Cerebellar Cortex4.63 ± 0.34
Cerebellar Nuclei5.33 ± 0.54
Claustrum4.87 ± 0.6
Epithalamus5.54 ± 0.4
Frontal Lobe4.82 ± 0.48
Globus Pallidus6.69 ± 0.54
Hypothalamus5.22 ± 0.56
Insula4.95 ± 0.46
Limbic Lobe4.71 ± 0.56
Mesencephalon5.3 ± 0.6
Myelencephalon5.12 ± 0.59
Occipital Lobe5.29 ± 0.51
Parietal Lobe5.08 ± 0.49
Pontine Tegmentum5.34 ± 0.36
Striatum5.74 ± 0.55
Subthalamus5.2 ± 0.62
Temporal Lobe4.88 ± 0.52
Thalamus5.32 ± 0.48
White Matter4.92 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Bcar3CBCerebellum12.83
19.37
Bcar3CTXCerebral cortex7.23
5.73
Bcar3HIPHippocampal region1.61
1.45
Bcar3HPFHippocampal formation1.35
1.24
Bcar3HYHypothalamus0.19
0.15
Bcar3LSXLateral septal complex1.05
1.08
Bcar3MBMidbrain3.6
5.34
Bcar3MYMedulla3.64
4.52
Bcar3OLFOlfactory bulb9.33
9.09
Bcar3PPons1.64
2.7
Bcar3PALPallidum1.05
1.05
Bcar3RHPRetrohippocampal region0.85
0.71
Bcar3sAMYStriatum-like amygdalar nuclei0.26
0.65
Bcar3STRStriatum1.1
1.12
Bcar3STRdStriatum dorsal region1.25
1.3
Bcar3STRvStriatum ventral region0.98
0.8
Bcar3THThalamus1.15
1.04
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
BCAR3_HUMAN_2 10 2 11 AAGKFASLPR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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