AutismKB 2.0

Annotation Detail for WDR75


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Basic Information Top
Gene Symbol:WDR75 ( DKFZp781N1244,FLJ12519,NET16 )
Gene Full Name: WD repeat domain 75
Band: 2q32.2
Quick LinksEntrez ID:84128; OMIM: NA; Uniprot ID:WDR75_HUMAN; ENSEMBL ID: ENSG00000115368; HGNC ID: 25725
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst5 / 6231980
fetus28 / 56401249
neonate4 / 31097128
infant1 / 2362042
juvenile2 / 5555635
adult132 / 193912168
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor9 / 11424678
esophageal tumor2 / 17290115
gastrointestinal tumor5 / 11936941
germ cell tumor42 / 263845159
glioma12 / 106883112
head and neck tumor10 / 13630273
kidney tumor2 / 6895929
leukemia7 / 9584273
liver tumor8 / 9635983
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal207 / 336030761
ovarian tumor6 / 7668278
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer4 / 10268038
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor12 / 90257132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood10 / 12347880
bone7 / 7165597
bone marrow3 / 4880161
brain70 / 110098963
cervix0 / 481710 
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus2 / 2020998
eye3 / 21105414
heart6 / 8962666
intestine15 / 23447263
kidney14 / 21177766
larynx4 / 24145165
liver13 / 20774362
lung12 / 33697435
lymph0 / 442700 
lymph node7 / 9161076
mammary gland10 / 15327165
mouth8 / 67052119
muscle9 / 10771583
nerve1 / 1576863
ovary8 / 10205178
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta20 / 28082571
prostate6 / 18934531
salivary gland0 / 201550 
skin9 / 21057442
spleen5 / 5395292
stomach3 / 9661931
testis27 / 33044281
thymus7 / 8113186
thyroid1 / 4747321
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord1 / 1368073
uterus21 / 23287890
vascular6 / 51780115
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1660_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.19 ± 0.3
Basal Forebrain9.12 ± 0.18
Basal Part of Pons9.16 ± 0.28
Cerebellar Cortex9.18 ± 0.24
Cerebellar Nuclei9.23 ± 0.3
Claustrum9.23 ± 0.34
Epithalamus9.1 ± 0.17
Frontal Lobe9.05 ± 0.23
Globus Pallidus9.29 ± 0.12
Hypothalamus9.26 ± 0.25
Insula8.96 ± 0.17
Limbic Lobe9.2 ± 0.29
Mesencephalon9.24 ± 0.27
Myelencephalon9.15 ± 0.21
Occipital Lobe9.43 ± 0.26
Parietal Lobe9.23 ± 0.21
Pontine Tegmentum9.14 ± 0.22
Striatum9 ± 0.19
Subthalamus9.27 ± 0.11
Temporal Lobe9.05 ± 0.21
Thalamus9.17 ± 0.19
White Matter9.52 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Wdr75CBCerebellum22.1
25.54
Wdr75CTXCerebral cortex69.69
48.81
Wdr75HIPHippocampal region45.79
60.06
Wdr75HPFHippocampal formation51
54.27
Wdr75HYHypothalamus27.02
19.96
Wdr75LSXLateral septal complex39.99
26.55
Wdr75MBMidbrain40.27
33.18
Wdr75MYMedulla33.93
34.11
Wdr75OLFOlfactory bulb57.74
43.98
Wdr75PPons39.73
38.61
Wdr75PALPallidum33.97
28.56
Wdr75RHPRetrohippocampal region64.16
47.19
Wdr75sAMYStriatum-like amygdalar nuclei46.31
31.55
Wdr75STRStriatum44.4
29.78
Wdr75STRdStriatum dorsal region44.2
30.02
Wdr75STRvStriatum ventral region45.58
29.08
Wdr75THThalamus51.24
41.07
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010725 25 289 313 LGATIEHISVSPAGDLFCTSHSDNK Peptide Atlas
WDR75_HUMAN_1 8 1 8 MVEEENIR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018