AutismKB 2.0

Annotation Detail for RNF135


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Basic Information Top
Gene Symbol:RNF135 ( MGC13061,REUL,Riplet )
Gene Full Name: ring finger protein 135
Band: 17q11.2
Quick LinksEntrez ID:84282; OMIM: 611358; Uniprot ID:RN135_HUMAN; ENSEMBL ID: ENSG00000181481; HGNC ID: 21158
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult27 / 193912113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor12 / 26384545
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor7 / 68959101
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal44 / 336030713
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain6 / 11009895
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye1 / 2110544
heart1 / 8962611
intestine4 / 23447217
kidney11 / 21177751
larynx0 / 241450 
liver4 / 20774319
lung5 / 33697414
lymph0 / 442700 
lymph node1 / 9161010
mammary gland7 / 15327145
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta16 / 28082556
prostate8 / 18934542
salivary gland3 / 20155148
skin3 / 21057414
spleen1 / 5395218
stomach1 / 9661910
testis8 / 33044224
thymus1 / 8113112
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P39759
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.37 ± 0.84
Basal Forebrain3.46 ± 0.64
Basal Part of Pons2.77 ± 0.71
Cerebellar Cortex3.06 ± 0.58
Cerebellar Nuclei3.68 ± 0.83
Claustrum3.68 ± 0.6
Epithalamus3.85 ± 0.27
Frontal Lobe3.16 ± 0.69
Globus Pallidus4.79 ± 0.46
Hypothalamus3.4 ± 0.75
Insula3.22 ± 0.78
Limbic Lobe3.08 ± 0.8
Mesencephalon3.64 ± 0.67
Myelencephalon3.4 ± 0.7
Occipital Lobe3.45 ± 0.69
Parietal Lobe3.2 ± 0.79
Pontine Tegmentum3.41 ± 0.64
Striatum3.76 ± 0.76
Subthalamus3.67 ± 0.9
Temporal Lobe3.13 ± 0.64
Thalamus3.47 ± 0.5
White Matter4.28 ± 0.8
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rnf135CBCerebellum3.86
5.44
Rnf135CTXCerebral cortex2.37
2.43
Rnf135HIPHippocampal region2.46
2.62
Rnf135HPFHippocampal formation2.26
2.39
Rnf135HYHypothalamus4.06
3.11
Rnf135LSXLateral septal complex1.3
1.47
Rnf135MBMidbrain2.16
2.47
Rnf135MYMedulla2.37
2.51
Rnf135OLFOlfactory bulb3.72
4
Rnf135PPons2.81
3.46
Rnf135PALPallidum1.72
1.48
Rnf135RHPRetrohippocampal region1.85
2.09
Rnf135sAMYStriatum-like amygdalar nuclei2.91
2.23
Rnf135STRStriatum1.72
1.56
Rnf135STRdStriatum dorsal region1.48
1.49
Rnf135STRvStriatum ventral region1.92
1.37
Rnf135THThalamus1.47
1.76
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018