AutismKB 2.0

Annotation Detail for VPS25


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:VPS25 ( DERP9,EAP20,FAP20,MGC10540 )
Gene Full Name: vacuolar protein sorting 25 homolog (S. cerevisiae)
Band: 17q21.31
Quick LinksEntrez ID:84313; OMIM: 610907; Uniprot ID:VPS25_HUMAN; ENSEMBL ID: ENSG00000131475; HGNC ID: 28122
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body15 / 70761211
blastocyst6 / 6231996
fetus34 / 56401260
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult114 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma12 / 82823144
colorectal tumor6 / 11424652
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor6 / 26384522
glioma12 / 106883112
head and neck tumor10 / 13630273
kidney tumor2 / 6895929
leukemia2 / 9584220
liver tumor14 / 96359145
lung tumor9 / 10312787
lymphoma7 / 7175597
non-neoplasia4 / 9725041
normal193 / 336030757
ovarian tumor9 / 76682117
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS11 / 12568087
prostate cancer11 / 102680107
retinoblastoma3 / 4635664
skin tumor12 / 12494996
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites3 / 4001574
bladder2 / 2975767
blood7 / 12347856
bone11 / 71655153
bone marrow0 / 488010 
brain46 / 110098941
cervix5 / 48171103
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue26 / 215722120
esophagus1 / 2020949
eye20 / 21105494
heart6 / 8962666
intestine13 / 23447255
kidney15 / 21177770
larynx1 / 2414541
liver19 / 20774391
lung25 / 33697474
lymph4 / 4427090
lymph node4 / 9161043
mammary gland4 / 15327126
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary10 / 10205197
pancreas15 / 21481269
parathyroid3 / 20539146
pharynx7 / 41328169
pituitary gland0 / 165850 
placenta14 / 28082549
prostate16 / 18934584
salivary gland6 / 20155297
skin21 / 21057499
spleen0 / 539520 
stomach7 / 9661972
testis9 / 33044227
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus13 / 23287855
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_4900_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.39 ± 0.47
Basal Forebrain4.93 ± 0.39
Basal Part of Pons5.11 ± 0.47
Cerebellar Cortex4.83 ± 0.42
Cerebellar Nuclei4.87 ± 0.36
Claustrum5.59 ± 0.5
Epithalamus4.79 ± 0.13
Frontal Lobe5.06 ± 0.43
Globus Pallidus5.06 ± 0.28
Hypothalamus4.74 ± 0.5
Insula5.04 ± 0.23
Limbic Lobe5.06 ± 0.47
Mesencephalon4.98 ± 0.44
Myelencephalon4.93 ± 0.44
Occipital Lobe4.71 ± 0.38
Parietal Lobe4.94 ± 0.49
Pontine Tegmentum5.01 ± 0.41
Striatum4.9 ± 0.47
Subthalamus3.94 ± 0.56
Temporal Lobe5 ± 0.37
Thalamus4.94 ± 0.37
White Matter5.06 ± 0.09
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Vps25CBCerebellum46.92
89.79
Vps25CTXCerebral cortex79.52
63.64
Vps25HIPHippocampal region62.01
98.96
Vps25HPFHippocampal formation71.48
87.04
Vps25HYHypothalamus23.56
19.22
Vps25LSXLateral septal complex38.22
28.62
Vps25MBMidbrain38.54
38.51
Vps25MYMedulla42.3
53.74
Vps25OLFOlfactory bulb70.12
62.63
Vps25PPons34.78
44.35
Vps25PALPallidum28.27
26.97
Vps25RHPRetrohippocampal region86.36
75.64
Vps25sAMYStriatum-like amygdalar nuclei42.46
31.16
Vps25STRStriatum61.97
47.62
Vps25STRdStriatum dorsal region66.54
52.28
Vps25STRvStriatum ventral region61.4
44.17
Vps25THThalamus51.66
51.22
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00063687 10 152 161 ALQALQQEHK Peptide Atlas
VPS25_HUMAN_109 8 109 116 LIYQWVSR PRIDE
VPS25_HUMAN_12 14 12 25 FPPFFTLQPNVDTR PRIDE
VPS25_HUMAN_151 20 151 170 ALQALQQEHKAEIITVSDGR PRIDE
VPS25_HUMAN_67 15 67 81 KLPVESIQIVLEELR PRIDE
VPS25_HUMAN_67 16 67 82 KLPVESIQIVLEELRK PRIDE
VPS25_HUMAN_94 8 94 101 SSFLIMWR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018