AutismKB 2.0

Annotation Detail for ARFGAP2


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Basic Information Top
Gene Symbol:ARFGAP2 ( FLJ14576,FLJ26000,IRZ,ZNF289,Zfp289 )
Gene Full Name: ADP-ribosylation factor GTPase activating protein 2
Band: 11p11.2
Quick LinksEntrez ID:84364; OMIM: 606908; Uniprot ID:ARFG2_HUMAN; ENSEMBL ID: ENSG00000149182; HGNC ID: 13504
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst8 / 62319128
fetus99 / 564012175
neonate7 / 31097225
infant7 / 23620296
juvenile15 / 55556269
adult342 / 1939121176
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor9 / 9417895
cervical tumor9 / 34366261
chondrosarcoma10 / 82823120
colorectal tumor21 / 114246183
esophageal tumor4 / 17290231
gastrointestinal tumor16 / 119369134
germ cell tumor53 / 263845200
glioma24 / 106883224
head and neck tumor34 / 136302249
kidney tumor20 / 68959290
leukemia9 / 9584293
liver tumor15 / 96359155
lung tumor23 / 103127223
lymphoma12 / 71755167
non-neoplasia11 / 97250113
normal516 / 3360307153
ovarian tumor5 / 7668265
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS20 / 125680159
prostate cancer10 / 10268097
retinoblastoma8 / 46356172
skin tumor18 / 124949144
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor95 / 902571052
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland4 / 33197120
ascites8 / 40015199
bladder3 / 29757100
blood11 / 12347889
bone9 / 71655125
bone marrow1 / 4880120
brain280 / 1100989254
cervix15 / 48171311
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus4 / 20209197
eye29 / 211054137
heart6 / 8962666
intestine46 / 234472196
kidney35 / 211777165
larynx10 / 24145414
liver25 / 207743120
lung58 / 336974172
lymph5 / 44270112
lymph node9 / 9161098
mammary gland11 / 15327171
mouth18 / 67052268
muscle15 / 107715139
nerve2 / 15768126
ovary7 / 10205168
pancreas14 / 21481265
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta37 / 280825131
prostate21 / 189345110
salivary gland4 / 20155198
skin32 / 210574151
spleen21 / 53952389
stomach6 / 9661962
testis59 / 330442178
thymus22 / 81131271
thyroid9 / 47473189
tonsil4 / 16999235
trachea9 / 52413171
umbilical cord1 / 1368073
uterus116 / 232878498
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211975_at
Cell line Expression level Expression bar
721_B_lymphoblasts298.45
Adipocyte50.4
AdrenalCortex90.1
Adrenalgland89.15
Amygdala100.55
Appendix41.4
AtrioventricularNode38.1
BDCA4+_DentriticCells269.1
Bonemarrow100.3
BronchialEpithelialCells95.05
CD105+_Endothelial175.35
CD14+_Monocytes229.2
CD19+_BCells(neg._sel.)307.8
CD33+_Myeloid228.2
CD34+326.25
CD4+_Tcells328.2
CD56+_NKCells362.15
CD71+_EarlyErythroid198.35
CD8+_Tcells265.75
CardiacMyocytes100.85
Caudatenucleus87.75
Cerebellum104.65
CerebellumPeduncles181.8
CiliaryGanglion36
CingulateCortex108.95
Colorectaladenocarcinoma116.45
DorsalRootGanglion67.25
FetalThyroid153.9
Fetalbrain83.85
Fetalliver38.2
Fetallung95.15
GlobusPallidus76.95
Heart152.4
Hypothalamus189.6
Kidney56
Leukemia_chronicMyelogenousK-56265.2
Leukemia_promyelocytic-HL-6086.55
Leukemialymphoblastic(MOLT-4)108.2
Liver279.15
Lung231.8
Lymphnode89.2
Lymphoma_burkitts(Daudi)118.2
Lymphoma_burkitts(Raji)145.3
MedullaOblongata96.75
OccipitalLobe95.7
OlfactoryBulb93.7
Ovary51.5
Pancreas85.9
PancreaticIslet126.6
ParietalLobe89.4
Pituitary88.65
Placenta179.75
Pons88.75
PrefrontalCortex247.4
Prostate226.55
Salivarygland26.15
SkeletalMuscle117.35
Skin35.5
SmoothMuscle107.5
Spinalcord115.45
SubthalamicNucleus95.45
SuperiorCervicalGanglion83.75
TemporalLobe96.1
Testis121.05
TestisGermCell95.15
TestisIntersitial86.05
TestisLeydigCell41.05
TestisSeminiferousTubule78.6
Thalamus114.25
Thymus130.7
Thyroid176.85
Tongue119.9
Tonsil55.4
Trachea54.3
TrigeminalGanglion83.9
Uterus113.3
UterusCorpus94.3
WholeBlood137.35
Wholebrain172.35
colon82.3
pineal_day295.24
pineal_night249.76
retina226.45
small_intestine73.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_8894_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.04 ± 0.34
Basal Forebrain6.73 ± 0.3
Basal Part of Pons6.79 ± 0.31
Cerebellar Cortex6.57 ± 0.33
Cerebellar Nuclei6.53 ± 0.36
Claustrum7.36 ± 0.39
Epithalamus6.21 ± 0.42
Frontal Lobe6.64 ± 0.41
Globus Pallidus7.23 ± 0.31
Hypothalamus6.27 ± 0.45
Insula6.65 ± 0.36
Limbic Lobe7.03 ± 0.38
Mesencephalon6.76 ± 0.34
Myelencephalon6.74 ± 0.41
Occipital Lobe6.99 ± 0.37
Parietal Lobe6.85 ± 0.42
Pontine Tegmentum6.73 ± 0.48
Striatum6.65 ± 0.41
Subthalamus6.71 ± 0.36
Temporal Lobe6.7 ± 0.44
Thalamus6.7 ± 0.23
White Matter7.44 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfp289CBCerebellum42.09
90.76
Zfp289CTXCerebral cortex100
100
Zfp289HIPHippocampal region100
100
Zfp289HPFHippocampal formation100
100
Zfp289HYHypothalamus100
100
Zfp289LSXLateral septal complex100
100
Zfp289MBMidbrain100
100
Zfp289MYMedulla65.15
89.33
Zfp289OLFOlfactory bulb100
100
Zfp289PPons66.65
90.62
Zfp289PALPallidum100
100
Zfp289RHPRetrohippocampal region100
100
Zfp289sAMYStriatum-like amygdalar nuclei100
100
Zfp289STRStriatum100
100
Zfp289STRdStriatum dorsal region100
100
Zfp289STRvStriatum ventral region100
100
Zfp289THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ARFG2_HUMAN_2 15 2 16 AAEPNKTEIQTLFKR PRIDE
ARFG2_HUMAN_413 10 413 422 SSGLESSEAR PRIDE
PAp00069411 21 129 149 HGTDLWIDNMSSAVPNHSPEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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