AutismKB 2.0

Annotation Detail for NCK2


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Basic Information Top
Gene Symbol:NCK2 ( GRB4,NCKbeta )
Gene Full Name: NCK adaptor protein 2
Band: 2q12.2
Quick LinksEntrez ID:8440; OMIM: 604930; Uniprot ID:NCK2_HUMAN; ENSEMBL ID: ENSG00000071051; HGNC ID: 7665
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus27 / 56401247
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor25 / 26384594
glioma17 / 106883159
head and neck tumor6 / 13630244
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor5 / 10312748
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal102 / 336030730
ovarian tumor4 / 7668252
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer0 / 1026800 
retinoblastoma3 / 4635664
skin tumor73 / 124949584
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone3 / 7165541
bone marrow1 / 4880120
brain35 / 110098931
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye13 / 21105461
heart4 / 8962644
intestine5 / 23447221
kidney10 / 21177747
larynx0 / 241450 
liver3 / 20774314
lung12 / 33697435
lymph0 / 442700 
lymph node3 / 9161032
mammary gland8 / 15327152
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary7 / 10205168
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta33 / 280825117
prostate0 / 1893450 
salivary gland3 / 20155148
skin74 / 210574351
spleen3 / 5395255
stomach6 / 9661962
testis8 / 33044224
thymus0 / 811310 
thyroid3 / 4747363
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus9 / 23287838
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203315_at
Cell line Expression level Expression bar
721_B_lymphoblasts230.6
Adipocyte89.25
AdrenalCortex94.8
Adrenalgland104.65
Amygdala149.35
Appendix65.5
AtrioventricularNode18.4
BDCA4+_DentriticCells200
Bonemarrow125
BronchialEpithelialCells156.55
CD105+_Endothelial100.2
CD14+_Monocytes146.7
CD19+_BCells(neg._sel.)1755.4
CD33+_Myeloid157.4
CD34+222.15
CD4+_Tcells900.1
CD56+_NKCells441.55
CD71+_EarlyErythroid57.1
CD8+_Tcells780.2
CardiacMyocytes127.3
Caudatenucleus57.4
Cerebellum154.75
CerebellumPeduncles193.15
CiliaryGanglion43.3
CingulateCortex142
Colorectaladenocarcinoma124.25
DorsalRootGanglion21.5
FetalThyroid177.4
Fetalbrain401.1
Fetalliver58.2
Fetallung250.6
GlobusPallidus89.2
Heart123.55
Hypothalamus108.45
Kidney90.95
Leukemia_chronicMyelogenousK-56226.7
Leukemia_promyelocytic-HL-6031.9
Leukemialymphoblastic(MOLT-4)97.05
Liver54.55
Lung289.7
Lymphnode148.8
Lymphoma_burkitts(Daudi)89.4
Lymphoma_burkitts(Raji)147.7
MedullaOblongata97.3
OccipitalLobe120.05
OlfactoryBulb87.7
Ovary31.2
Pancreas139
PancreaticIslet148.3
ParietalLobe137.95
Pituitary128.5
Placenta348.4
Pons65.05
PrefrontalCortex291.35
Prostate343.9
Salivarygland129.55
SkeletalMuscle124.6
Skin51.75
SmoothMuscle138
Spinalcord107.75
SubthalamicNucleus116.45
SuperiorCervicalGanglion49.3
TemporalLobe111.4
Testis123.85
TestisGermCell348.15
TestisIntersitial123.8
TestisLeydigCell119.25
TestisSeminiferousTubule125
Thalamus116.1
Thymus93.9
Thyroid328.1
Tongue129.3
Tonsil140.95
Trachea116.05
TrigeminalGanglion26.35
Uterus159.75
UterusCorpus74.25
WholeBlood455
Wholebrain287.6
colon140.95
pineal_day161.58
pineal_night152.68
retina237.9
small_intestine380.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7502_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.41 ± 0.34
Basal Forebrain5.38 ± 0.13
Basal Part of Pons5.47 ± 0.46
Cerebellar Cortex6.36 ± 0.35
Cerebellar Nuclei5.35 ± 0.54
Claustrum4.83 ± 0.85
Epithalamus5.81 ± 0.58
Frontal Lobe5.63 ± 0.48
Globus Pallidus5.06 ± 0.32
Hypothalamus4.99 ± 0.58
Insula5.56 ± 0.31
Limbic Lobe5.93 ± 0.64
Mesencephalon5.58 ± 0.47
Myelencephalon5.62 ± 0.48
Occipital Lobe6.48 ± 0.69
Parietal Lobe5.84 ± 0.42
Pontine Tegmentum5.54 ± 0.65
Striatum5.03 ± 0.44
Subthalamus5.28 ± 0.19
Temporal Lobe5.65 ± 0.47
Thalamus5.56 ± 0.43
White Matter5.26 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nck2CBCerebellum0.76
1.34
Nck2CTXCerebral cortex39.41
32.99
Nck2HIPHippocampal region53.43
100
Nck2HPFHippocampal formation38.67
66.79
Nck2HYHypothalamus35.89
28.95
Nck2LSXLateral septal complex39.69
30.31
Nck2MBMidbrain7.56
8.16
Nck2MYMedulla1.25
1.78
Nck2OLFOlfactory bulb29.96
30.03
Nck2PPons6.98
8.1
Nck2PALPallidum19.06
15.79
Nck2RHPRetrohippocampal region5.01
4.26
Nck2sAMYStriatum-like amygdalar nuclei18.93
15.49
Nck2STRStriatum13.67
10.44
Nck2STRdStriatum dorsal region8.48
6.57
Nck2STRvStriatum ventral region15.59
10.83
Nck2THThalamus27.73
26.06
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00352398 21 88 108 DASPTPSTDAEYPANGSGADR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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