AutismKB 2.0

Annotation Detail for DYRK3


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Basic Information Top
Gene Symbol:DYRK3 ( DYRK5,RED,REDK,hYAK3-2 )
Gene Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
Band: 1q32.1
Quick LinksEntrez ID:8444; OMIM: 603497; Uniprot ID:DYRK3_HUMAN; ENSEMBL ID: ENSG00000143479; HGNC ID: 3094
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus17 / 56401230
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult19 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor6 / 26384522
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal50 / 336030714
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain12 / 110098910
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart2 / 8962622
intestine0 / 2344720 
kidney2 / 2117779
larynx0 / 241450 
liver2 / 2077439
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen1 / 5395218
stomach0 / 966190 
testis27 / 33044281
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210151_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.15
Adipocyte15.85
AdrenalCortex15.05
Adrenalgland12.4
Amygdala15.15
Appendix23.7
AtrioventricularNode11.1
BDCA4+_DentriticCells14
Bonemarrow18.35
BronchialEpithelialCells15.2
CD105+_Endothelial19.55
CD14+_Monocytes14.3
CD19+_BCells(neg._sel.)14.4
CD33+_Myeloid14.9
CD34+24.75
CD4+_Tcells16.05
CD56+_NKCells14.9
CD71+_EarlyErythroid41
CD8+_Tcells11.35
CardiacMyocytes20.2
Caudatenucleus12.6
Cerebellum11.85
CerebellumPeduncles17.05
CiliaryGanglion10.15
CingulateCortex14.9
Colorectaladenocarcinoma16.05
DorsalRootGanglion11.1
FetalThyroid18.45
Fetalbrain19.7
Fetalliver19.8
Fetallung12.45
GlobusPallidus10.15
Heart19.65
Hypothalamus17
Kidney11.75
Leukemia_chronicMyelogenousK-56222.35
Leukemia_promyelocytic-HL-6013.15
Leukemialymphoblastic(MOLT-4)13.6
Liver19.3
Lung14.6
Lymphnode11.7
Lymphoma_burkitts(Daudi)18.85
Lymphoma_burkitts(Raji)19.95
MedullaOblongata16.1
OccipitalLobe13.1
OlfactoryBulb11.55
Ovary13.75
Pancreas12.2
PancreaticIslet26.75
ParietalLobe15.35
Pituitary23.3
Placenta13.65
Pons14.15
PrefrontalCortex14.15
Prostate17.6
Salivarygland13.5
SkeletalMuscle16.7
Skin11.05
SmoothMuscle17.4
Spinalcord15.6
SubthalamicNucleus13.1
SuperiorCervicalGanglion21.6
TemporalLobe13.1
Testis74.3
TestisGermCell43.65
TestisIntersitial75.35
TestisLeydigCell51.35
TestisSeminiferousTubule42.6
Thalamus13.7
Thymus11.8
Thyroid18.75
Tongue16.75
Tonsil20.75
Trachea15.15
TrigeminalGanglion19
Uterus12
UterusCorpus13.15
WholeBlood16.2
Wholebrain11.15
colon13.35
pineal_day14.1
pineal_night12.92
retina16.25
small_intestine14
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P345209
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.9 ± 0.37
Basal Forebrain3.17 ± 0.93
Basal Part of Pons2.97 ± 0.6
Cerebellar Cortex3.51 ± 0.59
Cerebellar Nuclei3.06 ± 0.56
Claustrum3.6 ± 0.67
Epithalamus5 ± 0.83
Frontal Lobe3.94 ± 0.6
Globus Pallidus3.3 ± 0.69
Hypothalamus3.87 ± 0.51
Insula4.06 ± 0.41
Limbic Lobe4.21 ± 0.6
Mesencephalon3.68 ± 0.58
Myelencephalon3.75 ± 0.66
Occipital Lobe3.5 ± 0.5
Parietal Lobe3.56 ± 0.65
Pontine Tegmentum3.88 ± 0.69
Striatum3.28 ± 1.01
Subthalamus2.97 ± 0.49
Temporal Lobe3.77 ± 0.58
Thalamus3.73 ± 0.59
White Matter2.35 ± 0.45
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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