AutismKB 2.0

Annotation Detail for LZTS2


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Basic Information Top
Gene Symbol:LZTS2 ( KIAA1813,LAPSER1 )
Gene Full Name: leucine zipper, putative tumor suppressor 2
Band: 10q24.31
Quick LinksEntrez ID:84445; OMIM: 610454; Uniprot ID:LZTS2_HUMAN; ENSEMBL ID: ENSG00000107816; HGNC ID: 29381
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst6 / 6231996
fetus7 / 56401212
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor8 / 26384530
glioma5 / 10688346
head and neck tumor0 / 1363020 
kidney tumor5 / 6895972
leukemia6 / 9584262
liver tumor8 / 9635983
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal86 / 336030725
ovarian tumor4 / 7668252
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor17 / 124949136
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow4 / 4880181
brain22 / 110098919
cervix2 / 4817141
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus0 / 202090 
eye9 / 21105442
heart3 / 8962633
intestine15 / 23447263
kidney16 / 21177775
larynx0 / 241450 
liver8 / 20774338
lung20 / 33697459
lymph1 / 4427022
lymph node4 / 9161043
mammary gland4 / 15327126
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate7 / 18934536
salivary gland0 / 201550 
skin20 / 21057494
spleen0 / 539520 
stomach5 / 9661951
testis2 / 3304426
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus17 / 23287872
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P149852
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.46 ± 0.5
Basal Forebrain7.35 ± 0.41
Basal Part of Pons7.11 ± 0.73
Cerebellar Cortex7.39 ± 0.56
Cerebellar Nuclei7.73 ± 0.52
Claustrum6.33 ± 0.71
Epithalamus7.29 ± 0.68
Frontal Lobe7.19 ± 0.65
Globus Pallidus7.72 ± 0.36
Hypothalamus7.05 ± 0.34
Insula6.95 ± 0.53
Limbic Lobe6.83 ± 0.56
Mesencephalon7.2 ± 0.65
Myelencephalon7.25 ± 0.59
Occipital Lobe7.06 ± 0.61
Parietal Lobe7.02 ± 0.52
Pontine Tegmentum7.24 ± 0.53
Striatum7.25 ± 0.5
Subthalamus7.3 ± 0.22
Temporal Lobe7.17 ± 0.48
Thalamus7.58 ± 0.51
White Matter9.23 ± 0.15
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lzts2CBCerebellum66.7
100
Lzts2CTXCerebral cortex100
100
Lzts2HIPHippocampal region86.07
100
Lzts2HPFHippocampal formation97.97
100
Lzts2HYHypothalamus65.7
68.43
Lzts2LSXLateral septal complex69.49
55.82
Lzts2MBMidbrain89
97.08
Lzts2MYMedulla91.88
100
Lzts2OLFOlfactory bulb100
100
Lzts2PPons92.85
100
Lzts2PALPallidum78.43
88.15
Lzts2RHPRetrohippocampal region100
100
Lzts2sAMYStriatum-like amygdalar nuclei100
100
Lzts2STRStriatum100
100
Lzts2STRdStriatum dorsal region100
100
Lzts2STRvStriatum ventral region91.77
84.17
Lzts2THThalamus75.21
80.47
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LZTS2_HUMAN_157 12 157 168 GAPSLPSFMGPR PRIDE
PAp00501450 32 223 254 NSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018