AutismKB 2.0

Annotation Detail for DCTN5


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Basic Information Top
Gene Symbol:DCTN5 ( MGC3248,p25 )
Gene Full Name: dynactin 5 (p25)
Band: 16p12.2
Quick LinksEntrez ID:84516; OMIM: 612962; Uniprot ID:DCTN5_HUMAN; ENSEMBL ID: ENSG00000166847; HGNC ID: 24594
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst11 / 62319176
fetus53 / 56401293
neonate3 / 3109796
infant0 / 236200 
juvenile10 / 55556179
adult134 / 193912169
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor6 / 11424652
esophageal tumor2 / 17290115
gastrointestinal tumor14 / 119369117
germ cell tumor42 / 263845159
glioma8 / 10688374
head and neck tumor25 / 136302183
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor11 / 96359114
lung tumor9 / 10312787
lymphoma8 / 71755111
non-neoplasia14 / 97250143
normal285 / 336030784
ovarian tumor4 / 7668252
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer7 / 10268068
retinoblastoma6 / 46356129
skin tumor9 / 12494972
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites4 / 4001599
bladder1 / 2975733
blood5 / 12347840
bone7 / 7165597
bone marrow0 / 488010 
brain125 / 1100989113
cervix0 / 481710 
connective tissue18 / 149255120
ear0 / 162120 
embryonic tissue25 / 215722115
esophagus2 / 2020998
eye20 / 21105494
heart2 / 8962622
intestine17 / 23447272
kidney9 / 21177742
larynx0 / 241450 
liver15 / 20774372
lung26 / 33697477
lymph4 / 4427090
lymph node12 / 91610130
mammary gland17 / 153271110
mouth21 / 67052313
muscle7 / 10771564
nerve1 / 1576863
ovary7 / 10205168
pancreas14 / 21481265
parathyroid2 / 2053997
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta21 / 28082574
prostate12 / 18934563
salivary gland2 / 2015599
skin18 / 21057485
spleen5 / 5395292
stomach9 / 9661993
testis40 / 330442121
thymus15 / 81131184
thyroid4 / 4747384
tonsil1 / 1699958
trachea20 / 52413381
umbilical cord0 / 136800 
uterus16 / 23287868
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209231_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts34.65
Adipocyte3.9
AdrenalCortex4.15
Adrenalgland3.85
Amygdala4.15
Appendix4
AtrioventricularNode3.05
BDCA4+_DentriticCells16.95
Bonemarrow3.85
BronchialEpithelialCells14.7
CD105+_Endothelial9.8
CD14+_Monocytes4.2
CD19+_BCells(neg._sel.)5.15
CD33+_Myeloid6.75
CD34+6.9
CD4+_Tcells12.05
CD56+_NKCells9.1
CD71+_EarlyErythroid3.7
CD8+_Tcells9.35
CardiacMyocytes8.35
Caudatenucleus3.5
Cerebellum3.75
CerebellumPeduncles4.45
CiliaryGanglion2.8
CingulateCortex3.9
Colorectaladenocarcinoma4.15
DorsalRootGanglion3.1
FetalThyroid3.85
Fetalbrain4
Fetalliver4.3
Fetallung3.15
GlobusPallidus2.95
Heart4.95
Hypothalamus4.25
Kidney3.65
Leukemia_chronicMyelogenousK-5623.9
Leukemia_promyelocytic-HL-604
Leukemialymphoblastic(MOLT-4)3.55
Liver5.15
Lung5.15
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.1
Lymphoma_burkitts(Raji)5.5
MedullaOblongata3.6
OccipitalLobe3.5
OlfactoryBulb3.1
Ovary2.6
Pancreas3.2
PancreaticIslet4.25
ParietalLobe4.2
Pituitary4.6
Placenta6.1
Pons3.7
PrefrontalCortex4.85
Prostate4.7
Salivarygland3.25
SkeletalMuscle4.7
Skin3.6
SmoothMuscle7
Spinalcord4.6
SubthalamicNucleus3.55
SuperiorCervicalGanglion5.4
TemporalLobe3.6
Testis18.4
TestisGermCell3.65
TestisIntersitial4.75
TestisLeydigCell4.15
TestisSeminiferousTubule3.4
Thalamus3.95
Thymus4.5
Thyroid5
Tongue3.85
Tonsil6.35
Trachea3.6
TrigeminalGanglion3.85
Uterus3.25
UterusCorpus3.5
WholeBlood4.3
Wholebrain3.5
colon4.45
pineal_day8.36
pineal_night6
retina5.65
small_intestine3.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7056_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.39 ± 0.49
Basal Forebrain5 ± 0.37
Basal Part of Pons5.1 ± 0.21
Cerebellar Cortex5.27 ± 0.33
Cerebellar Nuclei5.24 ± 0.45
Claustrum5.25 ± 0.38
Epithalamus5.09 ± 0.14
Frontal Lobe5.33 ± 0.39
Globus Pallidus4.75 ± 0.37
Hypothalamus5.2 ± 0.25
Insula5.45 ± 0.27
Limbic Lobe5.34 ± 0.38
Mesencephalon5.38 ± 0.42
Myelencephalon5.22 ± 0.39
Occipital Lobe5.03 ± 0.33
Parietal Lobe5.23 ± 0.42
Pontine Tegmentum5.25 ± 0.41
Striatum5.17 ± 0.43
Subthalamus5.52 ± 0.42
Temporal Lobe5.38 ± 0.34
Thalamus5.11 ± 0.45
White Matter5.06 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dctn5CBCerebellum65.11
100
Dctn5CTXCerebral cortex100
100
Dctn5HIPHippocampal region97.4
100
Dctn5HPFHippocampal formation100
100
Dctn5HYHypothalamus16.65
12.49
Dctn5LSXLateral septal complex6.17
4.05
Dctn5MBMidbrain32.03
31.38
Dctn5MYMedulla15.4
18.05
Dctn5OLFOlfactory bulb75.19
86.81
Dctn5PPons16.76
18.75
Dctn5PALPallidum30.84
29.12
Dctn5RHPRetrohippocampal region100
100
Dctn5sAMYStriatum-like amygdalar nuclei100
100
Dctn5STRStriatum80.51
65.45
Dctn5STRdStriatum dorsal region89.54
72.81
Dctn5STRvStriatum ventral region53.49
44.08
Dctn5THThalamus35.72
29.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DCTN5_HUMAN_1 24 1 24 MELGELLYNKSEYIETASGNKVSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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