AutismKB 2.0

Annotation Detail for CUL3


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Basic Information Top
Gene Symbol:CUL3 ( - )
Gene Full Name: cullin 3
Band: 2q36.2
Quick LinksEntrez ID:8452; OMIM: 603136; Uniprot ID:CUL3_HUMAN; ENSEMBL ID: ENSG00000036257; HGNC ID: 2553
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst3 / 6231948
fetus44 / 56401278
neonate0 / 310970 
infant2 / 2362084
juvenile7 / 55556125
adult150 / 193912177
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor4 / 34366116
chondrosarcoma13 / 82823156
colorectal tumor8 / 11424670
esophageal tumor2 / 17290115
gastrointestinal tumor10 / 11936983
germ cell tumor19 / 26384572
glioma11 / 106883102
head and neck tumor12 / 13630288
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor7 / 9635972
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia5 / 9725051
normal264 / 336030778
ovarian tumor4 / 7668252
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor7 / 12494956
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites4 / 4001599
bladder2 / 2975767
blood7 / 12347856
bone4 / 7165555
bone marrow3 / 4880161
brain57 / 110098951
cervix4 / 4817183
connective tissue12 / 14925580
ear0 / 162120 
embryonic tissue17 / 21572278
esophagus2 / 2020998
eye19 / 21105490
heart5 / 8962655
intestine21 / 23447289
kidney25 / 211777118
larynx1 / 2414541
liver16 / 20774377
lung19 / 33697456
lymph0 / 442700 
lymph node15 / 91610163
mammary gland12 / 15327178
mouth2 / 6705229
muscle5 / 10771546
nerve0 / 157680 
ovary4 / 10205139
pancreas15 / 21481269
parathyroid6 / 20539292
pharynx7 / 41328169
pituitary gland1 / 1658560
placenta15 / 28082553
prostate11 / 18934558
salivary gland0 / 201550 
skin13 / 21057461
spleen4 / 5395274
stomach7 / 9661972
testis56 / 330442169
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus15 / 23287864
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201370_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.55
Adipocyte8.6
AdrenalCortex11.55
Adrenalgland7.9
Amygdala16.25
Appendix11.7
AtrioventricularNode10.3
BDCA4+_DentriticCells8.8
Bonemarrow10.25
BronchialEpithelialCells8.5
CD105+_Endothelial15.6
CD14+_Monocytes9.7
CD19+_BCells(neg._sel.)13.95
CD33+_Myeloid11.25
CD34+17
CD4+_Tcells10.2
CD56+_NKCells12.65
CD71+_EarlyErythroid9.3
CD8+_Tcells9.95
CardiacMyocytes13.5
Caudatenucleus9.4
Cerebellum7.75
CerebellumPeduncles11.65
CiliaryGanglion13.8
CingulateCortex14.45
Colorectaladenocarcinoma8.8
DorsalRootGanglion7.9
FetalThyroid9.75
Fetalbrain13.4
Fetalliver8.35
Fetallung7
GlobusPallidus8.3
Heart12.8
Hypothalamus13.1
Kidney8
Leukemia_chronicMyelogenousK-5628.2
Leukemia_promyelocytic-HL-608.4
Leukemialymphoblastic(MOLT-4)6.7
Liver12.45
Lung9.25
Lymphnode7.6
Lymphoma_burkitts(Daudi)13.6
Lymphoma_burkitts(Raji)13.95
MedullaOblongata10.85
OccipitalLobe8.65
OlfactoryBulb8
Ovary7.05
Pancreas7.65
PancreaticIslet9.8
ParietalLobe11.1
Pituitary10.4
Placenta7.65
Pons9.95
PrefrontalCortex15.15
Prostate10.65
Salivarygland8.05
SkeletalMuscle13.55
Skin9.1
SmoothMuscle9.95
Spinalcord10.2
SubthalamicNucleus9.75
SuperiorCervicalGanglion14.75
TemporalLobe11.45
Testis7.6
TestisGermCell8.45
TestisIntersitial9.75
TestisLeydigCell10.25
TestisSeminiferousTubule11.15
Thalamus10
Thymus6.45
Thyroid19.45
Tongue10.35
Tonsil9.85
Trachea7.1
TrigeminalGanglion12.4
Uterus8.75
UterusCorpus12.55
WholeBlood11
Wholebrain7
colon9.55
pineal_day23.32
pineal_night20.7
retina10.925
small_intestine7.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P140030
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.43 ± 0.37
Basal Forebrain6.19 ± 0.17
Basal Part of Pons6.36 ± 0.25
Cerebellar Cortex6.42 ± 0.32
Cerebellar Nuclei6.27 ± 0.46
Claustrum6.62 ± 0.46
Epithalamus6.29 ± 0.34
Frontal Lobe6.34 ± 0.33
Globus Pallidus5.59 ± 0.38
Hypothalamus6.34 ± 0.33
Insula6.41 ± 0.27
Limbic Lobe6.29 ± 0.47
Mesencephalon6.32 ± 0.48
Myelencephalon6.24 ± 0.44
Occipital Lobe6.28 ± 0.55
Parietal Lobe6.36 ± 0.33
Pontine Tegmentum6.26 ± 0.38
Striatum5.93 ± 0.4
Subthalamus6.58 ± 0.37
Temporal Lobe6.37 ± 0.34
Thalamus6.2 ± 0.29
White Matter5.48 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cul3CBCerebellum100
100
Cul3CTXCerebral cortex100
100
Cul3HIPHippocampal region100
100
Cul3HPFHippocampal formation100
100
Cul3HYHypothalamus72.11
41.27
Cul3LSXLateral septal complex87.14
53.74
Cul3MBMidbrain93.23
66.4
Cul3MYMedulla96.48
89
Cul3OLFOlfactory bulb97.3
85.52
Cul3PPons90.98
76.67
Cul3PALPallidum84.56
63.15
Cul3RHPRetrohippocampal region100
100
Cul3sAMYStriatum-like amygdalar nuclei93.73
61.17
Cul3STRStriatum100
66.14
Cul3STRdStriatum dorsal region100
70.53
Cul3STRvStriatum ventral region100
61.4
Cul3THThalamus89.5
63.18
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CUL3_HUMAN_163 9 163 171 QTLLDMIAR PRIDE
CUL3_HUMAN_174 7 174 180 KGEVVDR PRIDE
CUL3_HUMAN_2 10 2 11 SNLSKGTGSR PRIDE
CUL3_HUMAN_255 8 255 262 STEEPIVK PRIDE
CUL3_HUMAN_275 15 275 289 TIVEMENSGLVHMLK PRIDE
CUL3_HUMAN_355 10 355 364 FLLESFNNDR PRIDE
CUL3_HUMAN_368 28 368 395 QTIAGDFEYFLNLNSRSPEYLSLFIDDK PRIDE
CUL3_HUMAN_39 8 39 46 NAIQEIQR PRIDE
CUL3_HUMAN_401 19 401 419 GLTEQEVETILDKAMVLFR PRIDE
CUL3_HUMAN_489 18 489 506 QHLQATGVSLGGVDLTVR PRIDE
CUL3_HUMAN_547 22 547 568 QLTLQHHMGSADLNATFYGPVK PRIDE
CUL3_HUMAN_60 9 60 68 NAYTMVLHK PRIDE
CUL3_HUMAN_630 13 630 642 ALQSLACGKPTQR PRIDE
CUL3_HUMAN_681 8 681 688 QGESDPER PRIDE
CUL3_HUMAN_693 17 693 709 QKVDDDRKHEIEAAIVR PRIDE
CUL3_HUMAN_73 6 73 78 LYTGLR PRIDE
CUL3_HUMAN_734 9 734 742 FLPSPVVIK PRIDE
CUL3_HUMAN_745 7 745 751 IEGLIER PRIDE
PAp00009282 13 630 642 ALQSLACGKPTQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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