AutismKB 2.0

Annotation Detail for CUL2


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Basic Information Top
Gene Symbol:CUL2 ( MGC131970 )
Gene Full Name: cullin 2
Band: 10p11.21
Quick LinksEntrez ID:8453; OMIM: 603135; Uniprot ID:CUL2_HUMAN; ENSEMBL ID: ENSG00000108094; HGNC ID: 2552
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst4 / 6231964
fetus22 / 56401239
neonate6 / 31097192
infant0 / 236200 
juvenile2 / 5555635
adult101 / 193912152
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor1 / 3436629
chondrosarcoma6 / 8282372
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor12 / 26384545
glioma4 / 10688337
head and neck tumor10 / 13630273
kidney tumor4 / 6895958
leukemia5 / 9584252
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal173 / 336030751
ovarian tumor3 / 7668239
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer4 / 10268038
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites2 / 4001549
bladder3 / 29757100
blood10 / 12347880
bone10 / 71655139
bone marrow0 / 488010 
brain68 / 110098961
cervix2 / 4817141
connective tissue10 / 14925566
ear1 / 1621261
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye5 / 21105423
heart3 / 8962633
intestine8 / 23447234
kidney16 / 21177775
larynx1 / 2414541
liver11 / 20774352
lung3 / 3369748
lymph1 / 4427022
lymph node2 / 9161021
mammary gland12 / 15327178
mouth10 / 67052149
muscle2 / 10771518
nerve2 / 15768126
ovary3 / 10205129
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta11 / 28082539
prostate11 / 18934558
salivary gland0 / 201550 
skin11 / 21057452
spleen0 / 539520 
stomach4 / 9661941
testis58 / 330442175
thymus2 / 8113124
thyroid1 / 4747321
tonsil1 / 1699958
trachea3 / 5241357
umbilical cord0 / 136800 
uterus15 / 23287864
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203078_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.85
Adipocyte10.2
AdrenalCortex19.55
Adrenalgland11.2
Amygdala11.2
Appendix22.6
AtrioventricularNode18.85
BDCA4+_DentriticCells10.5
Bonemarrow13.95
BronchialEpithelialCells10.35
CD105+_Endothelial12.65
CD14+_Monocytes14.5
CD19+_BCells(neg._sel.)11.05
CD33+_Myeloid20.35
CD34+12.75
CD4+_Tcells10.85
CD56+_NKCells12.4
CD71+_EarlyErythroid11.15
CD8+_Tcells9.85
CardiacMyocytes26.7
Caudatenucleus10.05
Cerebellum9.05
CerebellumPeduncles15.65
CiliaryGanglion15.05
CingulateCortex12.35
Colorectaladenocarcinoma10.75
DorsalRootGanglion12.8
FetalThyroid12.25
Fetalbrain9.95
Fetalliver10.15
Fetallung7.55
GlobusPallidus10.9
Heart25.35
Hypothalamus10.55
Kidney12.75
Leukemia_chronicMyelogenousK-5629.5
Leukemia_promyelocytic-HL-609.55
Leukemialymphoblastic(MOLT-4)8.15
Liver20.65
Lung11.7
Lymphnode8.7
Lymphoma_burkitts(Daudi)15.4
Lymphoma_burkitts(Raji)19.3
MedullaOblongata9.85
OccipitalLobe10.05
OlfactoryBulb8.5
Ovary10.15
Pancreas10.65
PancreaticIslet12.8
ParietalLobe14.15
Pituitary12.85
Placenta9.7
Pons11.85
PrefrontalCortex12.85
Prostate12.2
Salivarygland9.9
SkeletalMuscle25.35
Skin14.9
SmoothMuscle12.3
Spinalcord11.6
SubthalamicNucleus12.3
SuperiorCervicalGanglion26.95
TemporalLobe11.2
Testis9.15
TestisGermCell8.35
TestisIntersitial10.1
TestisLeydigCell12.65
TestisSeminiferousTubule9.45
Thalamus11.85
Thymus7.65
Thyroid12.05
Tongue15.05
Tonsil11.45
Trachea9
TrigeminalGanglion20.8
Uterus8.45
UterusCorpus13.95
WholeBlood11.75
Wholebrain9.1
colon10.8
pineal_day12.88
pineal_night12.84
retina12.725
small_intestine10.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11760_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.59 ± 0.45
Basal Forebrain5.26 ± 0.38
Basal Part of Pons5.9 ± 0.33
Cerebellar Cortex5.79 ± 0.43
Cerebellar Nuclei5.6 ± 0.35
Claustrum5.34 ± 0.7
Epithalamus5.76 ± 0.37
Frontal Lobe5.93 ± 0.37
Globus Pallidus5.15 ± 0.37
Hypothalamus5.96 ± 0.41
Insula5.96 ± 0.39
Limbic Lobe5.7 ± 0.62
Mesencephalon5.54 ± 0.58
Myelencephalon5.59 ± 0.6
Occipital Lobe5.11 ± 0.65
Parietal Lobe5.71 ± 0.49
Pontine Tegmentum5.75 ± 0.46
Striatum5.2 ± 0.52
Subthalamus5.98 ± 0.38
Temporal Lobe5.92 ± 0.43
Thalamus5.52 ± 0.57
White Matter5.8 ± 0.46
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cul2CBCerebellum67.99
100
Cul2CTXCerebral cortex100
100
Cul2HIPHippocampal region100
100
Cul2HPFHippocampal formation100
100
Cul2HYHypothalamus84.29
90.12
Cul2LSXLateral septal complex67.78
57.83
Cul2MBMidbrain65.27
81.34
Cul2MYMedulla57.78
86.04
Cul2OLFOlfactory bulb100
100
Cul2PPons64.22
87.69
Cul2PALPallidum100
100
Cul2RHPRetrohippocampal region100
100
Cul2sAMYStriatum-like amygdalar nuclei100
100
Cul2STRStriatum100
100
Cul2STRdStriatum dorsal region100
100
Cul2STRvStriatum ventral region100
100
Cul2THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CUL2_HUMAN_150 12 150 161 LMVEPLQAILIR PRIDE
CUL2_HUMAN_303 23 303 325 AVSTGLPHMIQELQNHIHDEGLR PRIDE
CUL2_HUMAN_660 10 660 669 DTPQEMEQTR PRIDE
PAp00041855 21 270 290 MVADHLQFLHAECHNIIRQEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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