AutismKB 2.0

Annotation Detail for TUBB6


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Basic Information Top
Gene Symbol:TUBB6 ( HsT1601,MGC132410,MGC4083,TUBB-5 )
Gene Full Name: tubulin, beta 6
Band: 18p11.21
Quick LinksEntrez ID:84617; OMIM: NA; Uniprot ID:TBB6_HUMAN; ENSEMBL ID: ENSG00000176014; HGNC ID: 20776
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body21 / 70761296
blastocyst25 / 62319401
fetus45 / 56401279
neonate10 / 31097321
infant4 / 23620169
juvenile5 / 5555689
adult190 / 193912197
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult1 / 19391210 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor4 / 9417842
cervical tumor2 / 3436658
chondrosarcoma22 / 82823265
colorectal tumor4 / 11424635
esophageal tumor4 / 17290231
gastrointestinal tumor14 / 119369117
germ cell tumor30 / 263845113
glioma16 / 106883149
head and neck tumor23 / 136302168
kidney tumor11 / 68959159
leukemia1 / 9584210
liver tumor22 / 96359228
lung tumor10 / 10312796
lymphoma0 / 717550 
non-neoplasia19 / 97250195
normal324 / 336030796
ovarian tumor4 / 7668252
pancreatic tumor18 / 104616172
primitive neuroectodermal tumor of the CNS19 / 125680151
prostate cancer9 / 10268087
retinoblastoma0 / 463560 
skin tumor46 / 124949368
soft tissue/muscle tissue tumor37 / 125191295
uterine tumor17 / 90257188
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal2 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland1 / 3319730
ascites1 / 4001524
bladder2 / 2975767
blood1 / 1234788
bone11 / 71655153
bone marrow1 / 4880120
brain59 / 110098953
cervix2 / 4817141
connective tissue30 / 149255200
ear1 / 1621261
embryonic tissue56 / 215722259
esophagus5 / 20209247
eye16 / 21105475
heart15 / 89626167
intestine20 / 23447285
kidney21 / 21177799
larynx0 / 241450 
liver28 / 207743134
lung48 / 336974142
lymph0 / 442700 
lymph node1 / 9161010
mammary gland17 / 153271110
mouth12 / 67052178
muscle7 / 10771564
nerve1 / 1576863
ovary4 / 10205139
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta40 / 280825142
prostate18 / 18934595
salivary gland3 / 20155148
skin67 / 210574318
spleen1 / 5395218
stomach7 / 9661972
testis16 / 33044248
thymus0 / 811310 
thyroid12 / 47473252
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord7 / 13680511
uterus66 / 232878283
vascular19 / 51780366
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209191_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.05
Adipocyte1072.45
AdrenalCortex27.2
Adrenalgland45
Amygdala44.6
Appendix98.35
AtrioventricularNode23.25
BDCA4+_DentriticCells318.7
Bonemarrow78.5
BronchialEpithelialCells2552
CD105+_Endothelial632.9
CD14+_Monocytes38.4
CD19+_BCells(neg._sel.)52.45
CD33+_Myeloid56.2
CD34+57.1
CD4+_Tcells13.05
CD56+_NKCells12.75
CD71+_EarlyErythroid476.7
CD8+_Tcells8.95
CardiacMyocytes1551.25
Caudatenucleus18
Cerebellum33.55
CerebellumPeduncles30.1
CiliaryGanglion62.8
CingulateCortex28.25
Colorectaladenocarcinoma569.45
DorsalRootGanglion38.4
FetalThyroid371.9
Fetalbrain30.45
Fetalliver352.35
Fetallung338.6
GlobusPallidus15.05
Heart468.45
Hypothalamus48
Kidney31.9
Leukemia_chronicMyelogenousK-562617.25
Leukemia_promyelocytic-HL-6019.2
Leukemialymphoblastic(MOLT-4)13.5
Liver88.8
Lung1060.25
Lymphnode91.7
Lymphoma_burkitts(Daudi)17.7
Lymphoma_burkitts(Raji)24.45
MedullaOblongata16.85
OccipitalLobe14.8
OlfactoryBulb183.15
Ovary94.5
Pancreas42.85
PancreaticIslet58.8
ParietalLobe24.75
Pituitary68.4
Placenta246.95
Pons41.8
PrefrontalCortex40.7
Prostate331.95
Salivarygland31.4
SkeletalMuscle37.25
Skin60.15
SmoothMuscle2101.45
Spinalcord42.65
SubthalamicNucleus11.75
SuperiorCervicalGanglion40.45
TemporalLobe17.6
Testis169.75
TestisGermCell116.9
TestisIntersitial123.3
TestisLeydigCell52.55
TestisSeminiferousTubule58.2
Thalamus29
Thymus54.5
Thyroid255.15
Tongue272.25
Tonsil118.85
Trachea94.1
TrigeminalGanglion41.4
Uterus631.15
UterusCorpus173.25
WholeBlood38.75
Wholebrain26.85
colon467.85
pineal_day38.28
pineal_night30.66
retina141.7
small_intestine486.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tubb6CBCerebellum0.02
0.06
Tubb6CTXCerebral cortex0.21
0.39
Tubb6HIPHippocampal region0.03
0.5
Tubb6HPFHippocampal formation0.03
0.26
Tubb6HYHypothalamus0.01
0.08
Tubb6LSXLateral septal complex0
0
Tubb6MBMidbrain0.01
0.01
Tubb6MYMedulla0.01
0.03
Tubb6OLFOlfactory bulb1.88
2.58
Tubb6PPons0
0
Tubb6PALPallidum0
0
Tubb6RHPRetrohippocampal region0.03
0.04
Tubb6sAMYStriatum-like amygdalar nuclei0.04
0
Tubb6STRStriatum0.03
0.07
Tubb6STRdStriatum dorsal region0.03
0.1
Tubb6STRvStriatum ventral region0.05
0.03
Tubb6THThalamus0.01
0.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002087 17 3 19 EIVHIQAGQCGNQIGTK Peptide Atlas
TBB6_HUMAN_0 0 0 0 EVDEQMLAIQSK PRIDE
TBB6_HUMAN_0 0 0 0 GHYTEGAELVDAVLDVVR PRIDE
TBB6_HUMAN_0 0 0 0 GHYTEGAELVDAVLDVVRK PRIDE
TBB6_HUMAN_0 0 0 0 INVYYNESSSQK PRIDE
TBB6_HUMAN_0 0 0 0 NMMAACDPR PRIDE
TBB6_HUMAN_0 0 0 0 NSSYFVEWIPNNVK PRIDE
TBB6_HUMAN_0 0 0 0 SGPFGQLFRPDNFIFGQTGAGNNWAK PRIDE
TBB6_HUMAN_0 0 0 0 YLTVATVFR PRIDE
TBB6_HUMAN_103 18 103 120 GHYTEGAELVDAVLDVVR PRIDE
TBB6_HUMAN_103 19 103 121 GHYTEGAELVDAVLDVVRK PRIDE
TBB6_HUMAN_154 20 154 173 IREEFPDRIMNTFSVMPSPK PRIDE
TBB6_HUMAN_162 12 162 173 IMNTFSVMPSPK PRIDE
TBB6_HUMAN_163 12 163 174 IMNTFSVMPSPK PRIDE
TBB6_HUMAN_2 17 2 18 EIVHIQAGQCGNQIGTK PRIDE
TBB6_HUMAN_216 25 216 240 LTTPTYGDLNHLVSATMSGVTTSLR PRIDE
TBB6_HUMAN_216 35 216 250 LTTPTYGDLNHLVSATMSGVTTSLRFPGQLNADLR PRIDE
TBB6_HUMAN_217 25 217 241 LTTPTYGDLNHLVSATMSGVTTSLR PRIDE
TBB6_HUMAN_241 10 241 250 FPGQLNADLR PRIDE
TBB6_HUMAN_241 11 241 251 FPGQLNADLRK PRIDE
TBB6_HUMAN_242 10 242 251 FPGQLNADLR PRIDE
TBB6_HUMAN_251 11 251 261 KLAVNMVPFPR PRIDE
TBB6_HUMAN_251 25 251 275 KLAVNMVPFPRLHFFMPGFAPLTSR PRIDE
TBB6_HUMAN_252 10 252 261 LAVNMVPFPR PRIDE
TBB6_HUMAN_252 24 252 275 LAVNMVPFPRLHFFMPGFAPLTSR PRIDE
TBB6_HUMAN_253 10 253 262 LAVNMVPFPR PRIDE
TBB6_HUMAN_262 14 262 275 LHFFMPGFAPLTSR PRIDE
TBB6_HUMAN_282 15 282 296 ALTVPELTQQMFDAR PRIDE
TBB6_HUMAN_283 15 283 297 ALTVPELTQQMFDAR PRIDE
TBB6_HUMAN_297 9 297 305 NMMAACDPR PRIDE
TBB6_HUMAN_309 9 309 317 YLTVATVFR PRIDE
TBB6_HUMAN_324 12 324 335 EVDEQMLAIQSK PRIDE
TBB6_HUMAN_336 14 336 349 NSSYFVEWIPNNVK PRIDE
TBB6_HUMAN_350 9 350 358 VAVCDIPPR PRIDE
TBB6_HUMAN_362 17 362 378 MASTFIGNSTAIQELFK PRIDE
TBB6_HUMAN_362 18 362 379 MASTFIGNSTAIQELFKR PRIDE
TBB6_HUMAN_380 11 380 390 RISEQFSAMFR PRIDE
TBB6_HUMAN_381 10 381 390 ISEQFSAMFR PRIDE
TBB6_HUMAN_46 12 46 57 INVYYNESSSQK PRIDE
TBB6_HUMAN_62 15 62 76 AALVDLEPGTMDSVR PRIDE
TBB6_HUMAN_63 15 63 77 AALVDLEPGTMDSVR PRIDE
TBB6_HUMAN_77 26 77 102 SGPFGQLFRPDNFIFGQTGAGNNWAK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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