AutismKB 2.0

Annotation Detail for CDC42BPA


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Basic Information Top
Gene Symbol:CDC42BPA ( DKFZp686L1738,DKFZp686P1738,FLJ23347,KIAA0451,MRCK,MRCKA,PK428 )
Gene Full Name: CDC42 binding protein kinase alpha (DMPK-like)
Band: 1q42.13
Quick LinksEntrez ID:8476; OMIM: 603412; Uniprot ID:MRCKA_HUMAN; ENSEMBL ID: ENSG00000143776; HGNC ID: 1737
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus45 / 56401279
neonate1 / 3109732
infant2 / 2362084
juvenile2 / 5555635
adult95 / 193912148
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor9 / 26384534
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal200 / 336030759
ovarian tumor8 / 76682104
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer11 / 102680107
retinoblastoma6 / 46356129
skin tumor5 / 12494940
soft tissue/muscle tissue tumor10 / 12519179
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder3 / 29757100
blood0 / 1234780 
bone7 / 7165597
bone marrow0 / 488010 
brain53 / 110098948
cervix0 / 481710 
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye24 / 211054113
heart2 / 8962622
intestine11 / 23447246
kidney6 / 21177728
larynx0 / 241450 
liver16 / 20774377
lung12 / 33697435
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle6 / 10771555
nerve4 / 15768253
ovary9 / 10205188
pancreas15 / 21481269
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate15 / 18934579
salivary gland0 / 201550 
skin18 / 21057485
spleen0 / 539520 
stomach3 / 9661931
testis25 / 33044275
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord1 / 1368073
uterus19 / 23287881
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203794_at
Cell line Expression level Expression bar
721_B_lymphoblasts58.95
Adipocyte104.3
AdrenalCortex109.6
Adrenalgland101.95
Amygdala138.3
Appendix115.4
AtrioventricularNode98.5
BDCA4+_DentriticCells67.6
Bonemarrow106.15
BronchialEpithelialCells74.55
CD105+_Endothelial106.35
CD14+_Monocytes94.45
CD19+_BCells(neg._sel.)35.35
CD33+_Myeloid54.45
CD34+125.35
CD4+_Tcells32.1
CD56+_NKCells76
CD71+_EarlyErythroid94.05
CD8+_Tcells77.65
CardiacMyocytes116.05
Caudatenucleus161.1
Cerebellum86.45
CerebellumPeduncles146.45
CiliaryGanglion76.75
CingulateCortex207.7
Colorectaladenocarcinoma84.8
DorsalRootGanglion90.6
FetalThyroid103.05
Fetalbrain184.35
Fetalliver92.75
Fetallung86.55
GlobusPallidus77.25
Heart131.65
Hypothalamus224.3
Kidney85.85
Leukemia_chronicMyelogenousK-56297.7
Leukemia_promyelocytic-HL-6083.25
Leukemialymphoblastic(MOLT-4)84.25
Liver126.5
Lung115.65
Lymphnode91.65
Lymphoma_burkitts(Daudi)132.25
Lymphoma_burkitts(Raji)58.85
MedullaOblongata170.15
OccipitalLobe144.8
OlfactoryBulb85.25
Ovary74.3
Pancreas85.05
PancreaticIslet113.6
ParietalLobe117.25
Pituitary138.55
Placenta81.85
Pons164.45
PrefrontalCortex258.15
Prostate124.45
Salivarygland84.6
SkeletalMuscle98.2
Skin81.65
SmoothMuscle121.35
Spinalcord154.35
SubthalamicNucleus106.75
SuperiorCervicalGanglion153.7
TemporalLobe113.55
Testis90.5
TestisGermCell93.4
TestisIntersitial92.1
TestisLeydigCell104.45
TestisSeminiferousTubule105.9
Thalamus171.75
Thymus72.95
Thyroid132.2
Tongue120.05
Tonsil103.2
Trachea108.15
TrigeminalGanglion108.15
Uterus126.8
UterusCorpus78.25
WholeBlood65.9
Wholebrain90.9
colon106.4
pineal_day198.12
pineal_night208.9
retina141.85
small_intestine96.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P944299
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.4 ± 0.27
Basal Forebrain7.67 ± 0.18
Basal Part of Pons7.7 ± 0.23
Cerebellar Cortex7.6 ± 0.25
Cerebellar Nuclei7.69 ± 0.34
Claustrum7.6 ± 0.47
Epithalamus7.17 ± 0.37
Frontal Lobe7.49 ± 0.27
Globus Pallidus7.71 ± 0.17
Hypothalamus7.2 ± 0.42
Insula7.29 ± 0.35
Limbic Lobe7.64 ± 0.31
Mesencephalon7.52 ± 0.34
Myelencephalon7.54 ± 0.29
Occipital Lobe7.94 ± 0.31
Parietal Lobe7.63 ± 0.3
Pontine Tegmentum7.58 ± 0.33
Striatum7.65 ± 0.26
Subthalamus7.33 ± 0.43
Temporal Lobe7.47 ± 0.31
Thalamus7.71 ± 0.3
White Matter8.29 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cdc42bpaCBCerebellum100
100
Cdc42bpaCTXCerebral cortex100
100
Cdc42bpaHIPHippocampal region100
100
Cdc42bpaHPFHippocampal formation100
100
Cdc42bpaHYHypothalamus100
100
Cdc42bpaLSXLateral septal complex100
100
Cdc42bpaMBMidbrain100
100
Cdc42bpaMYMedulla100
100
Cdc42bpaOLFOlfactory bulb100
100
Cdc42bpaPPons100
100
Cdc42bpaPALPallidum100
100
Cdc42bpaRHPRetrohippocampal region100
100
Cdc42bpasAMYStriatum-like amygdalar nuclei100
100
Cdc42bpaSTRStriatum100
100
Cdc42bpaSTRdStriatum dorsal region100
100
Cdc42bpaSTRvStriatum ventral region100
100
Cdc42bpaTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00027474 8 116 123 RAETACFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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