AutismKB 2.0

Annotation Detail for FBXO18


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Basic Information Top
Gene Symbol:FBXO18 ( FBH1,FLJ14590,Fbx18,MGC131916,MGC141935,MGC141937 )
Gene Full Name: F-box protein, helicase, 18
Band: 10p15.1
Quick LinksEntrez ID:84893; OMIM: 607222; Uniprot ID:FBX18_HUMAN; ENSEMBL ID: ENSG00000134452; HGNC ID: 13620
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus31 / 56401254
neonate1 / 3109732
infant4 / 23620169
juvenile2 / 5555635
adult160 / 193912182
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor1 / 3436629
chondrosarcoma8 / 8282396
colorectal tumor12 / 114246105
esophageal tumor2 / 17290115
gastrointestinal tumor4 / 11936933
germ cell tumor11 / 26384541
glioma10 / 10688393
head and neck tumor25 / 136302183
kidney tumor6 / 6895987
leukemia11 / 95842114
liver tumor3 / 9635931
lung tumor5 / 10312748
lymphoma2 / 7175527
non-neoplasia8 / 9725082
normal187 / 336030755
ovarian tumor4 / 7668252
pancreatic tumor18 / 104616172
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer6 / 10268058
retinoblastoma6 / 46356129
skin tumor13 / 124949104
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland4 / 33197120
ascites2 / 4001549
bladder0 / 297570 
blood8 / 12347864
bone6 / 7165583
bone marrow1 / 4880120
brain56 / 110098950
cervix5 / 48171103
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus2 / 2020998
eye26 / 211054123
heart10 / 89626111
intestine23 / 23447298
kidney10 / 21177747
larynx1 / 2414541
liver10 / 20774348
lung33 / 33697497
lymph1 / 4427022
lymph node6 / 9161065
mammary gland9 / 15327158
mouth12 / 67052178
muscle4 / 10771537
nerve2 / 15768126
ovary6 / 10205158
pancreas39 / 214812181
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta10 / 28082535
prostate11 / 18934558
salivary gland4 / 20155198
skin21 / 21057499
spleen3 / 5395255
stomach2 / 9661920
testis32 / 33044296
thymus12 / 81131147
thyroid7 / 47473147
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus21 / 23287890
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6561_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.58 ± 0.45
Basal Forebrain6.91 ± 0.13
Basal Part of Pons6.6 ± 0.26
Cerebellar Cortex6.49 ± 0.17
Cerebellar Nuclei6.77 ± 0.28
Claustrum7.12 ± 0.37
Epithalamus6.47 ± 0.12
Frontal Lobe6.53 ± 0.26
Globus Pallidus6.83 ± 0.17
Hypothalamus6.46 ± 0.36
Insula6.51 ± 0.22
Limbic Lobe6.73 ± 0.29
Mesencephalon6.65 ± 0.26
Myelencephalon6.68 ± 0.33
Occipital Lobe6.97 ± 0.3
Parietal Lobe6.7 ± 0.28
Pontine Tegmentum6.73 ± 0.4
Striatum7.24 ± 0.31
Subthalamus6.91 ± 0.16
Temporal Lobe6.63 ± 0.24
Thalamus6.81 ± 0.25
White Matter6.84 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fbxo18CBCerebellum34.18
78.67
Fbxo18CTXCerebral cortex100
99.16
Fbxo18HIPHippocampal region87.49
100
Fbxo18HPFHippocampal formation84.31
96.17
Fbxo18HYHypothalamus96.79
96.95
Fbxo18LSXLateral septal complex91.35
84.85
Fbxo18MBMidbrain72.03
71.62
Fbxo18MYMedulla66.52
90.49
Fbxo18OLFOlfactory bulb100
100
Fbxo18PPons61.05
69.75
Fbxo18PALPallidum81.52
84.42
Fbxo18RHPRetrohippocampal region79.67
81.36
Fbxo18sAMYStriatum-like amygdalar nuclei100
100
Fbxo18STRStriatum94.86
89.02
Fbxo18STRdStriatum dorsal region92.86
87.15
Fbxo18STRvStriatum ventral region94.72
85.11
Fbxo18THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018