AutismKB 2.0

Annotation Detail for PPP1R15B


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Basic Information Top
Gene Symbol:PPP1R15B ( CREP,FLJ14744 )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 15B
Band: 1q32.1
Quick LinksEntrez ID:84919; OMIM: 613257; Uniprot ID:PR15B_HUMAN; ENSEMBL ID: ENSG00000158615; HGNC ID: 14951
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus21 / 56401237
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult177 / 193912191
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor4 / 34366116
chondrosarcoma7 / 8282384
colorectal tumor5 / 11424643
esophageal tumor5 / 17290289
gastrointestinal tumor2 / 11936916
germ cell tumor15 / 26384556
glioma9 / 10688384
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia26 / 95842271
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma2 / 7175527
non-neoplasia6 / 9725061
normal177 / 336030752
ovarian tumor2 / 7668226
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer11 / 102680107
retinoblastoma3 / 4635664
skin tumor3 / 12494924
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites1 / 4001524
bladder3 / 29757100
blood26 / 123478210
bone10 / 71655139
bone marrow3 / 4880161
brain30 / 110098927
cervix7 / 48171145
connective tissue8 / 14925553
ear1 / 1621261
embryonic tissue10 / 21572246
esophagus5 / 20209247
eye10 / 21105447
heart0 / 896260 
intestine10 / 23447242
kidney3 / 21177714
larynx0 / 241450 
liver11 / 20774352
lung10 / 33697429
lymph2 / 4427045
lymph node8 / 9161087
mammary gland13 / 15327184
mouth4 / 6705259
muscle5 / 10771546
nerve2 / 15768126
ovary3 / 10205129
pancreas15 / 21481269
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta42 / 280825149
prostate14 / 18934573
salivary gland0 / 201550 
skin5 / 21057423
spleen2 / 5395237
stomach1 / 9661910
testis16 / 33044248
thymus7 / 8113186
thyroid1 / 4747321
tonsil0 / 169990 
trachea6 / 52413114
umbilical cord0 / 136800 
uterus8 / 23287834
vascular5 / 5178096
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P160449
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.26 ± 0.41
Basal Forebrain5.31 ± 0.24
Basal Part of Pons4.88 ± 0.48
Cerebellar Cortex5.43 ± 0.26
Cerebellar Nuclei5.19 ± 0.57
Claustrum4.97 ± 0.68
Epithalamus5.34 ± 0.34
Frontal Lobe5.01 ± 0.42
Globus Pallidus5.18 ± 0.45
Hypothalamus4.7 ± 0.48
Insula4.88 ± 0.34
Limbic Lobe5.14 ± 0.46
Mesencephalon5.1 ± 0.53
Myelencephalon5.13 ± 0.47
Occipital Lobe5.58 ± 0.36
Parietal Lobe5.2 ± 0.36
Pontine Tegmentum5.27 ± 0.32
Striatum5.19 ± 0.68
Subthalamus4.92 ± 0.23
Temporal Lobe5.01 ± 0.41
Thalamus5.15 ± 0.44
White Matter5.82 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp1r15bCBCerebellum59.55
90.82
Ppp1r15bCTXCerebral cortex76.76
66.28
Ppp1r15bHIPHippocampal region52.54
93.35
Ppp1r15bHPFHippocampal formation63.16
87.19
Ppp1r15bHYHypothalamus19.81
16.12
Ppp1r15bLSXLateral septal complex31
23.41
Ppp1r15bMBMidbrain25.4
23.62
Ppp1r15bMYMedulla27.39
30
Ppp1r15bOLFOlfactory bulb70.59
69.42
Ppp1r15bPPons23.51
25.39
Ppp1r15bPALPallidum17.45
16.01
Ppp1r15bRHPRetrohippocampal region81.53
82.18
Ppp1r15bsAMYStriatum-like amygdalar nuclei31.66
24.48
Ppp1r15bSTRStriatum43.22
35.63
Ppp1r15bSTRdStriatum dorsal region43.9
37.94
Ppp1r15bSTRvStriatum ventral region52.35
38.6
Ppp1r15bTHThalamus34.41
32.31
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018