AutismKB 2.0

Annotation Detail for PRSS12


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Basic Information Top
Gene Symbol:PRSS12 ( BSSP-3,BSSP3,MGC12722,MRT1 )
Gene Full Name: protease, serine, 12 (neurotrypsin, motopsin)
Band: 4q26
Quick LinksEntrez ID:8492; OMIM: 606709; Uniprot ID:NETR_HUMAN; ENSEMBL ID: ENSG00000164099; HGNC ID: 9477
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus23 / 56401240
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor2 / 17290115
gastrointestinal tumor1 / 1193698
germ cell tumor13 / 26384549
glioma0 / 1068830 
head and neck tumor5 / 13630236
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal70 / 336030720
ovarian tumor1 / 7668213
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain13 / 110098911
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus2 / 2020998
eye4 / 21105418
heart1 / 8962611
intestine4 / 23447217
kidney0 / 2117770 
larynx0 / 241450 
liver2 / 2077439
lung12 / 33697435
lymph0 / 442700 
lymph node0 / 916100 
mammary gland3 / 15327119
mouth5 / 6705274
muscle5 / 10771546
nerve0 / 157680 
ovary1 / 1020519
pancreas15 / 21481269
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta15 / 28082553
prostate2 / 18934510
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis11 / 33044233
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205515_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.8
Adipocyte7.1
AdrenalCortex8.45
Adrenalgland6.45
Amygdala7.35
Appendix8.6
AtrioventricularNode6.55
BDCA4+_DentriticCells7.1
Bonemarrow7.35
BronchialEpithelialCells7.15
CD105+_Endothelial7.05
CD14+_Monocytes7.45
CD19+_BCells(neg._sel.)7.3
CD33+_Myeloid8.4
CD34+8.4
CD4+_Tcells6.95
CD56+_NKCells8
CD71+_EarlyErythroid6.6
CD8+_Tcells6.55
CardiacMyocytes10.5
Caudatenucleus6.45
Cerebellum5.95
CerebellumPeduncles8.6
CiliaryGanglion5.85
CingulateCortex7.4
Colorectaladenocarcinoma7.15
DorsalRootGanglion6.15
FetalThyroid7
Fetalbrain9.1
Fetalliver6.3
Fetallung6
GlobusPallidus5.55
Heart12.6
Hypothalamus7.45
Kidney6.4
Leukemia_chronicMyelogenousK-5626.4
Leukemia_promyelocytic-HL-606.35
Leukemialymphoblastic(MOLT-4)5.5
Liver10.65
Lung7.9
Lymphnode5.95
Lymphoma_burkitts(Daudi)9.4
Lymphoma_burkitts(Raji)10.3
MedullaOblongata8.6
OccipitalLobe6.55
OlfactoryBulb5.6
Ovary5.45
Pancreas5.95
PancreaticIslet7.7
ParietalLobe7.95
Pituitary8.45
Placenta7.15
Pons7.25
PrefrontalCortex8.65
Prostate8.2
Salivarygland6.5
SkeletalMuscle10.45
Skin6.1
SmoothMuscle8
Spinalcord7.7
SubthalamicNucleus6.55
SuperiorCervicalGanglion13.7
TemporalLobe7.3
Testis6.1
TestisGermCell5.95
TestisIntersitial6.2
TestisLeydigCell7.4
TestisSeminiferousTubule6.55
Thalamus7.35
Thymus5.45
Thyroid8.6
Tongue9.1
Tonsil7.1
Trachea6.05
TrigeminalGanglion8.5
Uterus5.7
UterusCorpus7.05
WholeBlood7.7
Wholebrain5.8
colon7.2
pineal_day8.96
pineal_night8.6
retina8.8
small_intestine6.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P230869
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.65 ± 0.86
Basal Forebrain2.96 ± 0.47
Basal Part of Pons2.88 ± 0.46
Cerebellar Cortex2.78 ± 0.5
Cerebellar Nuclei3.12 ± 0.58
Claustrum3.38 ± 0.55
Epithalamus4.52 ± 0.53
Frontal Lobe3.66 ± 0.69
Globus Pallidus3.18 ± 0.89
Hypothalamus2.72 ± 0.47
Insula3.2 ± 0.46
Limbic Lobe3.5 ± 0.94
Mesencephalon3.6 ± 0.68
Myelencephalon3.31 ± 0.72
Occipital Lobe2.91 ± 0.87
Parietal Lobe3.84 ± 0.76
Pontine Tegmentum3.49 ± 0.87
Striatum2.86 ± 0.85
Subthalamus3.37 ± 0.34
Temporal Lobe3.23 ± 0.77
Thalamus3.37 ± 0.61
White Matter2.4 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prss12CBCerebellum2.48
3.76
Prss12CTXCerebral cortex32.75
32.14
Prss12HIPHippocampal region10.52
10.32
Prss12HPFHippocampal formation20.41
23.35
Prss12HYHypothalamus1.79
1.58
Prss12LSXLateral septal complex2.75
3.57
Prss12MBMidbrain2.43
2.47
Prss12MYMedulla5.59
8.55
Prss12OLFOlfactory bulb22.44
23.81
Prss12PPons2.12
3.84
Prss12PALPallidum1.17
1
Prss12RHPRetrohippocampal region35.38
38.43
Prss12sAMYStriatum-like amygdalar nuclei1.58
1.21
Prss12STRStriatum4.77
5.61
Prss12STRdStriatum dorsal region6.2
7.35
Prss12STRvStriatum ventral region1.3
1.56
Prss12THThalamus1.5
1.55
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp01419969 8 670 677 WVLTAAHC Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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