Annotation Detail for PPM1D
Basic Information Top
| Gene Symbol: | PPM1D ( PP2C-DELTA,WIP1 ) |
|---|---|
| Gene Full Name: | protein phosphatase, Mg2+/Mn2+ dependent, 1D |
| Band: | 17q23.3 |
| Quick Links | Entrez ID:8493; OMIM: 605100; Uniprot ID:PPM1D_HUMAN; ENSEMBL ID: ENSG00000170836; HGNC ID: 9277 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.286073
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 4 / 564012 | 7 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 9 / 1939121 | 4 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 2 / 82823 | 24 |  |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 4 / 106883 | 37 | |
| head and neck tumor | 1 / 136302 | 7 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 10 / 3360307 | 2 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 1 / 102680 | 9 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 2 / 71655 | 27 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 8 / 1100989 | 7 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 1 / 211054 | 4 | |
| heart | 0 / 89626 | 0 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 1 / 211777 | 4 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 1 / 336974 | 2 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 1 / 280825 | 3 | |
| prostate | 1 / 189345 | 5 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 2 / 330442 | 6 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 1 / 16999 | 58 |  |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204566_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 46.4 | |
| Adipocyte | 5.55 | |
| AdrenalCortex | 6.35 | |
| Adrenalgland | 4.95 | |
| Amygdala | 5.8 | |
| Appendix | 7.6 | |
| AtrioventricularNode | 5.2 | |
| BDCA4+_DentriticCells | 27.55 | |
| Bonemarrow | 6.6 | |
| BronchialEpithelialCells | 5.45 | |
| CD105+_Endothelial | 21.35 | |
| CD14+_Monocytes | 20.4 | |
| CD19+_BCells(neg._sel.) | 24.6 | |
| CD33+_Myeloid | 38 | |
| CD34+ | 128.35 | |
| CD4+_Tcells | 7.25 | |
| CD56+_NKCells | 29.95 | |
| CD71+_EarlyErythroid | 13.85 | |
| CD8+_Tcells | 5.65 | |
| CardiacMyocytes | 11.8 | |
| Caudatenucleus | 5.25 | |
| Cerebellum | 7.45 | |
| CerebellumPeduncles | 7.6 | |
| CiliaryGanglion | 5.3 | |
| CingulateCortex | 5.95 | |
| Colorectaladenocarcinoma | 5.95 | |
| DorsalRootGanglion | 5.45 | |
| FetalThyroid | 5.7 | |
| Fetalbrain | 5.55 | |
| Fetalliver | 5.1 | |
| Fetallung | 5 | |
| GlobusPallidus | 4.55 | |
| Heart | 8.35 | |
| Hypothalamus | 6.2 | |
| Kidney | 4.95 | |
| Leukemia_chronicMyelogenousK-562 | 5.2 | |
| Leukemia_promyelocytic-HL-60 | 5.15 | |
| Leukemialymphoblastic(MOLT-4) | 5.3 | |
| Liver | 8.85 | |
| Lung | 6.35 | |
| Lymphnode | 4.9 | |
| Lymphoma_burkitts(Daudi) | 8 | |
| Lymphoma_burkitts(Raji) | 8.7 | |
| MedullaOblongata | 6.95 | |
| OccipitalLobe | 5.1 | |
| OlfactoryBulb | 4.5 | |
| Ovary | 4.35 | |
| Pancreas | 4.75 | |
| PancreaticIslet | 6.25 | |
| ParietalLobe | 6.45 | |
| Pituitary | 6.7 | |
| Placenta | 37 | |
| Pons | 5.6 | |
| PrefrontalCortex | 7.05 | |
| Prostate | 6.7 | |
| Salivarygland | 5 | |
| SkeletalMuscle | 7.75 | |
| Skin | 5.45 | |
| SmoothMuscle | 6.6 | |
| Spinalcord | 6.15 | |
| SubthalamicNucleus | 5.3 | |
| SuperiorCervicalGanglion | 9.75 | |
| TemporalLobe | 5.4 | |
| Testis | 5.4 | |
| TestisGermCell | 4.75 | |
| TestisIntersitial | 6.7 | |
| TestisLeydigCell | 6.2 | |
| TestisSeminiferousTubule | 5.4 | |
| Thalamus | 5.85 | |
| Thymus | 4.7 | |
| Thyroid | 7.85 | |
| Tongue | 5.95 | |
| Tonsil | 5.65 | |
| Trachea | 8.1 | |
| TrigeminalGanglion | 7.4 | |
| Uterus | 8.35 | |
| UterusCorpus | 6.2 | |
| WholeBlood | 17.75 | |
| Wholebrain | 4.9 | |
| colon | 5.9 | |
| pineal_day | 7.36 | |
| pineal_night | 9.7 | |
| retina | 8.075 | |
| small_intestine | 6.55 | |
- Probe name: CUST_9867_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.48 ± 0.33 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 6.8 ± 0.45 | |
| Basal Part of Pons | 6.71 ± 0.31 | |
| Cerebellar Cortex | 7.1 ± 0.24 | |
| Cerebellar Nuclei | 6.76 ± 0.24 | |
| Claustrum | 6.6 ± 0.62 | |
| Epithalamus | 6.64 ± 0.37 | |
| Frontal Lobe | 6.5 ± 0.33 | |
| Globus Pallidus | 6.77 ± 0.49 | |
| Hypothalamus | 6.54 ± 0.36 | |
| Insula | 6.43 ± 0.16 | |
| Limbic Lobe | 6.66 ± 0.36 | |
| Mesencephalon | 6.59 ± 0.35 | |
| Myelencephalon | 6.63 ± 0.36 | |
| Occipital Lobe | 7 ± 0.38 | |
| Parietal Lobe | 6.62 ± 0.29 | |
| Pontine Tegmentum | 6.63 ± 0.38 | |
| Striatum | 6.8 ± 0.45 | |
| Subthalamus | 6.55 ± 0.15 | |
| Temporal Lobe | 6.58 ± 0.27 | |
| Thalamus | 6.7 ± 0.39 | |
| White Matter | 7.69 ± 0.41 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Ppm1d | CB | Cerebellum | 40.49 | |
| 43.44 | | |||
| Ppm1d | CTX | Cerebral cortex | 4.82 | |
| 3.58 | | |||
| Ppm1d | HIP | Hippocampal region | 12.2 | |
| 11.03 | | |||
| Ppm1d | HPF | Hippocampal formation | 13.51 | |
| 11.78 | | |||
| Ppm1d | HY | Hypothalamus | 2.42 | |
| 1.78 | | |||
| Ppm1d | LSX | Lateral septal complex | 2.47 | |
| 4.23 | | |||
| Ppm1d | MB | Midbrain | 1.12 | |
| 1.69 | | |||
| Ppm1d | MY | Medulla | 4.54 | |
| 5.23 | | |||
| Ppm1d | OLF | Olfactory bulb | 28.58 | |
| 20.95 | | |||
| Ppm1d | P | Pons | 4.77 | |
| 6.45 | | |||
| Ppm1d | PAL | Pallidum | 1.34 | |
| 1.04 | | |||
| Ppm1d | RHP | Retrohippocampal region | 15.93 | |
| 12.84 | | |||
| Ppm1d | sAMY | Striatum-like amygdalar nuclei | 6.5 | |
| 4.23 | | |||
| Ppm1d | STR | Striatum | 7.39 | |
| 5.13 | | |||
| Ppm1d | STRd | Striatum dorsal region | 6.23 | |
| 4.07 | | |||
| Ppm1d | STRv | Striatum ventral region | 14.21 | |
| 9.91 | | |||
| Ppm1d | TH | Thalamus | 0.75 | |
| 0.82 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PPM1D_HUMAN_43 | 30 | 43 | 72 | SLSQPLPPRPSPAALPGGEVSGKGPAVAAR | PRIDE |