AutismKB 2.0

Annotation Detail for ALKBH6


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Basic Information Top
Gene Symbol:ALKBH6 ( ABH6,MGC15677 )
Gene Full Name: alkB, alkylation repair homolog 6 (E. coli)
Band: 19q13.12
Quick LinksEntrez ID:84964; OMIM: 613304; Uniprot ID:ALKB6_HUMAN; ENSEMBL ID: ENSG00000181392,ENSG00000239382; HGNC ID: 28243
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult57 / 193912129
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor2 / 3436658
chondrosarcoma11 / 82823132
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor4 / 26384515
glioma6 / 10688356
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor6 / 9635962
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal86 / 336030725
ovarian tumor2 / 7668226
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites6 / 40015149
bladder1 / 2975733
blood4 / 12347832
bone7 / 7165597
bone marrow0 / 488010 
brain33 / 110098929
cervix2 / 4817141
connective tissue8 / 14925553
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye17 / 21105480
heart0 / 896260 
intestine6 / 23447225
kidney4 / 21177718
larynx0 / 241450 
liver6 / 20774328
lung12 / 33697435
lymph0 / 442700 
lymph node1 / 9161010
mammary gland4 / 15327126
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary5 / 10205148
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate7 / 18934536
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach2 / 9661920
testis2 / 3304426
thymus9 / 81131110
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus15 / 23287864
vascular0 / 517800 
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_12358_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.34 ± 0.46
Basal Forebrain6.09 ± 0.24
Basal Part of Pons6.62 ± 0.17
Cerebellar Cortex6.07 ± 0.28
Cerebellar Nuclei6.48 ± 0.25
Claustrum6.48 ± 0.47
Epithalamus5.54 ± 0.61
Frontal Lobe6.36 ± 0.32
Globus Pallidus6.05 ± 0.32
Hypothalamus6.31 ± 0.34
Insula6.12 ± 0.24
Limbic Lobe6.38 ± 0.35
Mesencephalon6.24 ± 0.42
Myelencephalon6.3 ± 0.38
Occipital Lobe6.13 ± 0.26
Parietal Lobe6.3 ± 0.36
Pontine Tegmentum6.23 ± 0.29
Striatum6.33 ± 0.3
Subthalamus6.31 ± 0.17
Temporal Lobe6.36 ± 0.3
Thalamus6.44 ± 0.31
White Matter5.99 ± 0.11
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Alkbh6CBCerebellum24.67
34.77
Alkbh6CTXCerebral cortex60.99
47
Alkbh6HIPHippocampal region34.98
44
Alkbh6HPFHippocampal formation47.42
50.51
Alkbh6HYHypothalamus38.69
32.06
Alkbh6LSXLateral septal complex19.54
14.8
Alkbh6MBMidbrain44.71
41.96
Alkbh6MYMedulla57.69
65.12
Alkbh6OLFOlfactory bulb55.78
47.36
Alkbh6PPons49.12
52.53
Alkbh6PALPallidum32.5
30.44
Alkbh6RHPRetrohippocampal region66.51
58.73
Alkbh6sAMYStriatum-like amygdalar nuclei29.2
22.85
Alkbh6STRStriatum20.88
15.48
Alkbh6STRdStriatum dorsal region17.88
13.12
Alkbh6STRvStriatum ventral region26.69
18.55
Alkbh6THThalamus34.56
28.65
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00497041 17 44 60 VEQAPPVIYYVPDFISK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018