AutismKB 2.0

Annotation Detail for PPFIA4


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Basic Information Top
Gene Symbol:PPFIA4 ( - )
Gene Full Name: protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
Band: 1q32.1
Quick LinksEntrez ID:8497; OMIM: 603145; Uniprot ID:LIPA4_HUMAN; ENSEMBL ID: ENSG00000143847; HGNC ID: 9248
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus5 / 5640128
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult31 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor4 / 26384515
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal74 / 336030722
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone0 / 716550 
bone marrow0 / 488010 
brain51 / 110098946
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye6 / 21105428
heart1 / 8962611
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214978_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.9
Adipocyte5.25
AdrenalCortex5.85
Adrenalgland4.55
Amygdala38.2
Appendix5.75
AtrioventricularNode4.4
BDCA4+_DentriticCells5.8
Bonemarrow5.35
BronchialEpithelialCells5.25
CD105+_Endothelial5.4
CD14+_Monocytes5.7
CD19+_BCells(neg._sel.)5.7
CD33+_Myeloid7.05
CD34+6.45
CD4+_Tcells5.7
CD56+_NKCells6
CD71+_EarlyErythroid5.05
CD8+_Tcells5.2
CardiacMyocytes7.45
Caudatenucleus10.2
Cerebellum217.85
CerebellumPeduncles234.7
CiliaryGanglion4
CingulateCortex33.25
Colorectaladenocarcinoma5.2
DorsalRootGanglion4.7
FetalThyroid5.25
Fetalbrain13.1
Fetalliver4.55
Fetallung4.25
GlobusPallidus10.75
Heart7.45
Hypothalamus15.35
Kidney4.4
Leukemia_chronicMyelogenousK-5624.85
Leukemia_promyelocytic-HL-604.55
Leukemialymphoblastic(MOLT-4)4.35
Liver7.9
Lung5.6
Lymphnode4.35
Lymphoma_burkitts(Daudi)6.65
Lymphoma_burkitts(Raji)7.45
MedullaOblongata33.9
OccipitalLobe49.35
OlfactoryBulb4.15
Ovary3.6
Pancreas4.35
PancreaticIslet5.75
ParietalLobe19.15
Pituitary5.95
Placenta5.25
Pons5.45
PrefrontalCortex152.55
Prostate6.1
Salivarygland4.35
SkeletalMuscle6.6
Skin4.3
SmoothMuscle6.05
Spinalcord5.7
SubthalamicNucleus25.55
SuperiorCervicalGanglion8.25
TemporalLobe42.65
Testis4.6
TestisGermCell4.3
TestisIntersitial4.55
TestisLeydigCell5.35
TestisSeminiferousTubule4.65
Thalamus16.45
Thymus3.95
Thyroid6.35
Tongue5.75
Tonsil5.2
Trachea4.5
TrigeminalGanglion7.3
Uterus4.15
UterusCorpus5.95
WholeBlood5.65
Wholebrain33.35
colon5.3
pineal_day273.02
pineal_night243.84
retina6.5
small_intestine5.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7643_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.89 ± 0.76
Basal Forebrain4.5 ± 0.75
Basal Part of Pons4.74 ± 0.31
Cerebellar Cortex5.44 ± 0.34
Cerebellar Nuclei4.22 ± 0.5
Claustrum5.4 ± 0.78
Epithalamus4.22 ± 1.06
Frontal Lobe4.3 ± 0.69
Globus Pallidus3.26 ± 0.81
Hypothalamus3.64 ± 0.36
Insula4.67 ± 0.7
Limbic Lobe4.92 ± 0.8
Mesencephalon4.43 ± 0.82
Myelencephalon4.56 ± 0.7
Occipital Lobe5.38 ± 0.62
Parietal Lobe4.95 ± 0.69
Pontine Tegmentum4.59 ± 0.95
Striatum3.87 ± 0.64
Subthalamus4.86 ± 2.18
Temporal Lobe4.84 ± 0.68
Thalamus4.53 ± 0.59
White Matter2.09 ± 0.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppfia4CBCerebellum100
100
Ppfia4CTXCerebral cortex29.77
20.55
Ppfia4HIPHippocampal region45.81
61.93
Ppfia4HPFHippocampal formation47.71
50.45
Ppfia4HYHypothalamus46.08
31.53
Ppfia4LSXLateral septal complex83.17
55.28
Ppfia4MBMidbrain35.21
28.27
Ppfia4MYMedulla52.02
51.18
Ppfia4OLFOlfactory bulb43.84
35.07
Ppfia4PPons43.83
39.05
Ppfia4PALPallidum44.51
34.96
Ppfia4RHPRetrohippocampal region50.95
35.99
Ppfia4sAMYStriatum-like amygdalar nuclei61.8
40.92
Ppfia4STRStriatum34.21
22.7
Ppfia4STRdStriatum dorsal region24.21
16.12
Ppfia4STRvStriatum ventral region40.58
26.13
Ppfia4THThalamus34.22
26.17
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00041550 12 113 124 LLLEHLECLVSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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