AutismKB 2.0

Annotation Detail for USP45


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Basic Information Top
Gene Symbol:USP45 ( MGC14793 )
Gene Full Name: ubiquitin specific peptidase 45
Band: 6q16.2
Quick LinksEntrez ID:85015; OMIM: NA; Uniprot ID:UBP45_HUMAN; ENSEMBL ID: ENSG00000123552; HGNC ID: 20080
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult28 / 193912114
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma7 / 8282384
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor3 / 26384511
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma4 / 7175555
non-neoplasia1 / 9725010
normal48 / 336030714
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone8 / 71655111
bone marrow1 / 4880120
brain14 / 110098912
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye2 / 2110549
heart0 / 896260 
intestine3 / 23447212
kidney3 / 21177714
larynx0 / 241450 
liver3 / 20774314
lung3 / 3369748
lymph1 / 4427022
lymph node2 / 9161021
mammary gland0 / 1532710 
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas2 / 2148129
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate1 / 1893455
salivary gland2 / 2015599
skin1 / 2105744
spleen0 / 539520 
stomach3 / 9661931
testis9 / 33044227
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P134008
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.99 ± 0.74
Basal Forebrain7.6 ± 0.34
Basal Part of Pons7.42 ± 0.3
Cerebellar Cortex8.13 ± 0.38
Cerebellar Nuclei7.5 ± 0.37
Claustrum7.21 ± 0.56
Epithalamus7.14 ± 0.54
Frontal Lobe7.38 ± 0.51
Globus Pallidus7.41 ± 0.35
Hypothalamus7.45 ± 0.33
Insula7.34 ± 0.41
Limbic Lobe7.49 ± 0.37
Mesencephalon7.71 ± 0.45
Myelencephalon7.42 ± 0.49
Occipital Lobe7.95 ± 0.4
Parietal Lobe7.71 ± 0.4
Pontine Tegmentum7.46 ± 0.56
Striatum7.29 ± 0.52
Subthalamus8.15 ± 0.2
Temporal Lobe7.27 ± 0.47
Thalamus7.66 ± 0.38
White Matter7.33 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp45CBCerebellum17.47
33.47
Usp45CTXCerebral cortex62.84
53.65
Usp45HIPHippocampal region44.34
76.3
Usp45HPFHippocampal formation45.33
61.63
Usp45HYHypothalamus12.14
11.27
Usp45LSXLateral septal complex11.33
8.73
Usp45MBMidbrain18.65
23.53
Usp45MYMedulla13.38
23.93
Usp45OLFOlfactory bulb37.41
33.33
Usp45PPons17.68
27.65
Usp45PALPallidum13.16
13.71
Usp45RHPRetrohippocampal region47.85
44.95
Usp45sAMYStriatum-like amygdalar nuclei17.46
13.24
Usp45STRStriatum27.1
20.61
Usp45STRdStriatum dorsal region29.16
22.05
Usp45STRvStriatum ventral region31.99
24.26
Usp45THThalamus38.86
40.71
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018