AutismKB 2.0

Annotation Detail for HAT1


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Basic Information Top
Gene Symbol:HAT1 ( KAT1 )
Gene Full Name: histone acetyltransferase 1
Band: 2q31.1
Quick LinksEntrez ID:8520; OMIM: 603053; Uniprot ID:HAT1_HUMAN; ENSEMBL ID: ENSG00000128708; HGNC ID: 4821
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus23 / 56401240
neonate2 / 3109764
infant1 / 2362042
juvenile0 / 555560 
adult89 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor10 / 94178106
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor3 / 26384511
glioma5 / 10688346
head and neck tumor6 / 13630244
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor7 / 9635972
lung tumor4 / 10312738
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal122 / 336030736
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder2 / 2975767
blood4 / 12347832
bone4 / 7165555
bone marrow1 / 4880120
brain16 / 110098914
cervix3 / 4817162
connective tissue4 / 14925526
ear3 / 16212185
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye5 / 21105423
heart5 / 8962655
intestine9 / 23447238
kidney5 / 21177723
larynx0 / 241450 
liver23 / 207743110
lung10 / 33697429
lymph1 / 4427022
lymph node7 / 9161076
mammary gland12 / 15327178
mouth6 / 6705289
muscle2 / 10771518
nerve0 / 157680 
ovary3 / 10205129
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta7 / 28082524
prostate5 / 18934526
salivary gland1 / 2015549
skin2 / 2105749
spleen3 / 5395255
stomach7 / 9661972
testis13 / 33044239
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord1 / 1368073
uterus10 / 23287842
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203138_at
Cell line Expression level Expression bar
721_B_lymphoblasts884.8
Adipocyte30.95
AdrenalCortex28.1
Adrenalgland16.45
Amygdala38.7
Appendix26.4
AtrioventricularNode24.45
BDCA4+_DentriticCells155.75
Bonemarrow23.25
BronchialEpithelialCells184.1
CD105+_Endothelial593.35
CD14+_Monocytes216.15
CD19+_BCells(neg._sel.)172.4
CD33+_Myeloid123.3
CD34+417.6
CD4+_Tcells86.2
CD56+_NKCells199.6
CD71+_EarlyErythroid687.95
CD8+_Tcells150.15
CardiacMyocytes111.95
Caudatenucleus22.15
Cerebellum14
CerebellumPeduncles20.85
CiliaryGanglion24.2
CingulateCortex16.75
Colorectaladenocarcinoma163.2
DorsalRootGanglion23.85
FetalThyroid27.1
Fetalbrain22.9
Fetalliver84.85
Fetallung46.85
GlobusPallidus19.8
Heart35.65
Hypothalamus40.4
Kidney16.65
Leukemia_chronicMyelogenousK-562187.8
Leukemia_promyelocytic-HL-60298.15
Leukemialymphoblastic(MOLT-4)179.75
Liver29.55
Lung15.95
Lymphnode29.25
Lymphoma_burkitts(Daudi)232
Lymphoma_burkitts(Raji)49.85
MedullaOblongata11.8
OccipitalLobe19.1
OlfactoryBulb21.3
Ovary42.75
Pancreas28.15
PancreaticIslet166
ParietalLobe25.95
Pituitary42
Placenta19.9
Pons25.95
PrefrontalCortex28.8
Prostate28.3
Salivarygland63.65
SkeletalMuscle46.75
Skin32.15
SmoothMuscle79.75
Spinalcord32.7
SubthalamicNucleus19.65
SuperiorCervicalGanglion34.55
TemporalLobe16.95
Testis13.55
TestisGermCell52.75
TestisIntersitial43.4
TestisLeydigCell33.45
TestisSeminiferousTubule28.2
Thalamus21.45
Thymus14.5
Thyroid97.2
Tongue37
Tonsil52.75
Trachea32.2
TrigeminalGanglion31.8
Uterus66.05
UterusCorpus21.65
WholeBlood162.45
Wholebrain12.25
colon85.05
pineal_day133.54
pineal_night182.6
retina34.475
small_intestine42.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P339480
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.89 ± 0.55
Basal Forebrain7.42 ± 0.08
Basal Part of Pons7.34 ± 0.34
Cerebellar Cortex7.28 ± 0.32
Cerebellar Nuclei7.32 ± 0.39
Claustrum6.8 ± 0.8
Epithalamus7.9 ± 0.42
Frontal Lobe7.27 ± 0.43
Globus Pallidus8.08 ± 0.3
Hypothalamus7.6 ± 0.25
Insula7.41 ± 0.34
Limbic Lobe6.83 ± 0.46
Mesencephalon7.27 ± 0.37
Myelencephalon7.22 ± 0.47
Occipital Lobe6.89 ± 0.36
Parietal Lobe7.14 ± 0.37
Pontine Tegmentum7.22 ± 0.39
Striatum7.5 ± 0.41
Subthalamus7.2 ± 0.65
Temporal Lobe7.08 ± 0.37
Thalamus7.32 ± 0.42
White Matter8.71 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hat1CBCerebellum6.08
6.82
Hat1CTXCerebral cortex3.11
2.32
Hat1HIPHippocampal region2.32
2.1
Hat1HPFHippocampal formation1.85
1.71
Hat1HYHypothalamus0.72
0.7
Hat1LSXLateral septal complex1.71
1.46
Hat1MBMidbrain2.2
2.02
Hat1MYMedulla5.2
5.43
Hat1OLFOlfactory bulb9.51
8.52
Hat1PPons3.2
3.5
Hat1PALPallidum0.44
0.31
Hat1RHPRetrohippocampal region0.87
1.03
Hat1sAMYStriatum-like amygdalar nuclei0.38
0.27
Hat1STRStriatum1.56
1.57
Hat1STRdStriatum dorsal region1.48
1.81
Hat1STRvStriatum ventral region1.94
1.13
Hat1THThalamus1.37
1.17
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
HAT1_HUMAN_248 15 248 262 QGQGHGAQLLETVHR PRIDE
HAT1_HUMAN_305 16 305 320 LMQGFNEDMAIEAQQK PRIDE
HAT1_HUMAN_337 13 337 349 LLVTDMSDAEQYR PRIDE
HAT1_HUMAN_399 12 399 410 EESFQELVEDYR PRIDE
PAp00008189 16 95 110 VDENFDCVEADDVEGK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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