AutismKB 2.0

Annotation Detail for DGKZ


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Basic Information Top
Gene Symbol:DGKZ ( DAGK5,DAGK6,DGK-ZETA,hDGKzeta )
Gene Full Name: diacylglycerol kinase, zeta 104kDa
Band: 11p11.2
Quick LinksEntrez ID:8525; OMIM: 601441; Uniprot ID:DGKZ_HUMAN; ENSEMBL ID: ENSG00000149091; HGNC ID: 2857
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst9 / 62319144
fetus19 / 56401233
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult99 / 193912151
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor17 / 119369142
germ cell tumor38 / 263845144
glioma5 / 10688346
head and neck tumor7 / 13630251
kidney tumor4 / 6895958
leukemia12 / 95842125
liver tumor3 / 9635931
lung tumor6 / 10312758
lymphoma5 / 7175569
non-neoplasia4 / 9725041
normal197 / 336030758
ovarian tumor1 / 7668213
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor6 / 12494948
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites15 / 40015374
bladder1 / 2975733
blood10 / 12347880
bone4 / 7165555
bone marrow0 / 488010 
brain98 / 110098989
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue23 / 215722106
esophagus0 / 202090 
eye9 / 21105442
heart1 / 8962611
intestine11 / 23447246
kidney8 / 21177737
larynx1 / 2414541
liver3 / 20774314
lung9 / 33697426
lymph4 / 4427090
lymph node13 / 91610141
mammary gland3 / 15327119
mouth5 / 6705274
muscle1 / 1077159
nerve0 / 157680 
ovary5 / 10205148
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta35 / 280825124
prostate3 / 18934515
salivary gland1 / 2015549
skin7 / 21057433
spleen4 / 5395274
stomach2 / 9661920
testis10 / 33044230
thymus17 / 81131209
thyroid3 / 4747363
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus8 / 23287834
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207556_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts41
Adipocyte5.5
AdrenalCortex7.4
Adrenalgland6.95
Amygdala282.9
Appendix5.05
AtrioventricularNode4
BDCA4+_DentriticCells125.3
Bonemarrow28.45
BronchialEpithelialCells11.7
CD105+_Endothelial36.45
CD14+_Monocytes83.65
CD19+_BCells(neg._sel.)25.4
CD33+_Myeloid163.85
CD34+152.2
CD4+_Tcells173.05
CD56+_NKCells212.4
CD71+_EarlyErythroid12.05
CD8+_Tcells146.8
CardiacMyocytes15.2
Caudatenucleus31.8
Cerebellum23.15
CerebellumPeduncles28.05
CiliaryGanglion6.85
CingulateCortex109.85
Colorectaladenocarcinoma21.45
DorsalRootGanglion4.95
FetalThyroid5.5
Fetalbrain12.6
Fetalliver7.05
Fetallung5.3
GlobusPallidus75.15
Heart27.7
Hypothalamus13.85
Kidney7.25
Leukemia_chronicMyelogenousK-5627.55
Leukemia_promyelocytic-HL-6010
Leukemialymphoblastic(MOLT-4)8.75
Liver13.25
Lung15.25
Lymphnode11.3
Lymphoma_burkitts(Daudi)14.3
Lymphoma_burkitts(Raji)18.4
MedullaOblongata53.35
OccipitalLobe49.55
OlfactoryBulb6.4
Ovary4.9
Pancreas10.65
PancreaticIslet13.6
ParietalLobe30.35
Pituitary14.55
Placenta22.8
Pons39.95
PrefrontalCortex298.4
Prostate25.05
Salivarygland9.1
SkeletalMuscle11.6
Skin6.3
SmoothMuscle10.4
Spinalcord10.85
SubthalamicNucleus76.2
SuperiorCervicalGanglion6.75
TemporalLobe131.75
Testis8.1
TestisGermCell7.9
TestisIntersitial10.1
TestisLeydigCell4.85
TestisSeminiferousTubule6.35
Thalamus13.2
Thymus24.1
Thyroid15
Tongue7.4
Tonsil12.45
Trachea4.25
TrigeminalGanglion5.4
Uterus8.8
UterusCorpus8.05
WholeBlood58.35
Wholebrain192
colon11.55
pineal_day23.14
pineal_night24.9
retina12.45
small_intestine17.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P127627
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.94 ± 0.5
Basal Forebrain7.31 ± 0.19
Basal Part of Pons7.35 ± 0.3
Cerebellar Cortex7.2 ± 0.3
Cerebellar Nuclei7.23 ± 0.39
Claustrum7.95 ± 0.39
Epithalamus6.87 ± 0.29
Frontal Lobe7.59 ± 0.45
Globus Pallidus6.45 ± 0.66
Hypothalamus7.01 ± 0.39
Insula7.6 ± 0.33
Limbic Lobe7.99 ± 0.47
Mesencephalon7.47 ± 0.49
Myelencephalon7.51 ± 0.45
Occipital Lobe7.71 ± 0.4
Parietal Lobe7.59 ± 0.48
Pontine Tegmentum7.44 ± 0.4
Striatum7.43 ± 0.65
Subthalamus7.17 ± 0.45
Temporal Lobe7.74 ± 0.38
Thalamus7.16 ± 0.35
White Matter6.4 ± 0.65
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DgkzCBCerebellum80.76
100
DgkzCTXCerebral cortex100
100
DgkzHIPHippocampal region100
100
DgkzHPFHippocampal formation100
100
DgkzHYHypothalamus82.51
70.79
DgkzLSXLateral septal complex100
100
DgkzMBMidbrain93.48
92.01
DgkzMYMedulla77.02
83.55
DgkzOLFOlfactory bulb100
100
DgkzPPons81.87
85.43
DgkzPALPallidum96.09
100
DgkzRHPRetrohippocampal region100
100
DgkzsAMYStriatum-like amygdalar nuclei100
94.9
DgkzSTRStriatum100
100
DgkzSTRdStriatum dorsal region100
96.53
DgkzSTRvStriatum ventral region100
100
DgkzTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DGKZ_HUMAN_826 9 826 834 QQPVPEQLR PRIDE
PAp00096873 22 249 270 SGLQHLAPPPPTPGAPCSESER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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