AutismKB 2.0

Annotation Detail for CPZ


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Basic Information Top
Gene Symbol:CPZ ( MGC99682 )
Gene Full Name: carboxypeptidase Z
Band: 4p16.1
Quick LinksEntrez ID:8532; OMIM: 603105; Uniprot ID:CBPZ_HUMAN; ENSEMBL ID: ENSG00000109625,ENSG00000155269; HGNC ID: 2333
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus17 / 56401230
neonate7 / 31097225
infant0 / 236200 
juvenile0 / 555560 
adult126 / 193912164
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor49 / 263845185
glioma3 / 10688328
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal107 / 336030731
ovarian tumor8 / 76682104
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain12 / 110098910
cervix1 / 4817120
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus1 / 2020949
eye4 / 21105418
heart4 / 8962644
intestine2 / 2344728
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary10 / 10205197
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta50 / 280825178
prostate2 / 18934510
salivary gland0 / 201550 
skin2 / 2105749
spleen2 / 5395237
stomach3 / 9661931
testis8 / 33044224
thymus2 / 8113124
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord5 / 13680365
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211062_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.75
Adipocyte7
AdrenalCortex8.2
Adrenalgland6.3
Amygdala7.35
Appendix7.25
AtrioventricularNode6.05
BDCA4+_DentriticCells6.7
Bonemarrow7.65
BronchialEpithelialCells6.6
CD105+_Endothelial6.5
CD14+_Monocytes6.85
CD19+_BCells(neg._sel.)7.1
CD33+_Myeloid8.35
CD34+8.1
CD4+_Tcells7.15
CD56+_NKCells7.6
CD71+_EarlyErythroid6.65
CD8+_Tcells6.15
CardiacMyocytes9.35
Caudatenucleus6.35
Cerebellum5.8
CerebellumPeduncles8.15
CiliaryGanglion5.8
CingulateCortex7.7
Colorectaladenocarcinoma6.85
DorsalRootGanglion5.6
FetalThyroid6.9
Fetalbrain6.95
Fetalliver6.25
Fetallung5.85
GlobusPallidus5.35
Heart11.35
Hypothalamus7.85
Kidney6.4
Leukemia_chronicMyelogenousK-56217.05
Leukemia_promyelocytic-HL-606.25
Leukemialymphoblastic(MOLT-4)5.7
Liver11.95
Lung10.15
Lymphnode5.95
Lymphoma_burkitts(Daudi)10.85
Lymphoma_burkitts(Raji)10.15
MedullaOblongata6.45
OccipitalLobe6.15
OlfactoryBulb5.6
Ovary4.95
Pancreas5.8
PancreaticIslet7.6
ParietalLobe7.7
Pituitary11.2
Placenta39.8
Pons7.55
PrefrontalCortex8.1
Prostate8.1
Salivarygland5.7
SkeletalMuscle10.15
Skin6.15
SmoothMuscle7.8
Spinalcord7.55
SubthalamicNucleus6.5
SuperiorCervicalGanglion8.75
TemporalLobe6.55
Testis6.05
TestisGermCell5.85
TestisIntersitial5.9
TestisLeydigCell7
TestisSeminiferousTubule6.35
Thalamus7.3
Thymus5.25
Thyroid9.35
Tongue7.35
Tonsil6.9
Trachea5.85
TrigeminalGanglion7.05
Uterus5.5
UterusCorpus8.55
WholeBlood7.4
Wholebrain5.7
colon6.9
pineal_day8.38
pineal_night8.26
retina8.925
small_intestine6.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_871_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.45 ± 0.63
Basal Forebrain4.42 ± 0.66
Basal Part of Pons4.19 ± 0.64
Cerebellar Cortex3.75 ± 0.67
Cerebellar Nuclei4.42 ± 0.49
Claustrum4.5 ± 0.88
Epithalamus3.41 ± 0.48
Frontal Lobe4.14 ± 0.77
Globus Pallidus5.08 ± 0.76
Hypothalamus3.73 ± 0.87
Insula3.93 ± 0.67
Limbic Lobe4.35 ± 0.77
Mesencephalon4.16 ± 0.82
Myelencephalon4.25 ± 0.79
Occipital Lobe3.99 ± 0.77
Parietal Lobe4.14 ± 0.8
Pontine Tegmentum4.1 ± 0.65
Striatum4.31 ± 0.81
Subthalamus2.72 ± 1.01
Temporal Lobe4.1 ± 0.72
Thalamus4.11 ± 0.66
White Matter4.72 ± 0.56
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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