Annotation Detail for SHANK3
Basic Information Top
| Gene Symbol: | SHANK3 ( DEL22q13.3,KIAA1650,PROSAP2,PSAP2,SPANK-2 ) |
|---|---|
| Gene Full Name: | SH3 and multiple ankyrin repeat domains 3 |
| Band: | 22q13.33 |
| Quick Links | Entrez ID:85358; OMIM: 606230; Uniprot ID:F2Z3L0_HUMAN; ENSEMBL ID: ENSG00000251322; HGNC ID: 14294 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.149035
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 1 / 70761 | 14 |  |
| blastocyst | 2 / 62319 | 32 | |
| fetus | 16 / 564012 | 28 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 39 / 1939121 | 20 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 1 / 94178 | 10 |  |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 7 / 82823 | 84 |  |
| colorectal tumor | 1 / 114246 | 8 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 2 / 119369 | 16 | |
| germ cell tumor | 2 / 263845 | 7 | |
| glioma | 6 / 106883 | 56 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 2 / 96359 | 20 | |
| lung tumor | 2 / 103127 | 19 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 61 / 3360307 | 18 | |
| ovarian tumor | 2 / 76682 | 26 | |
| pancreatic tumor | 2 / 104616 | 19 | |
| primitive neuroectodermal tumor of the CNS | 4 / 125680 | 31 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 1 / 46356 | 21 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 5 / 125191 | 39 | |
| uterine tumor | 2 / 90257 | 22 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 1 / 33197 | 30 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 4 / 71655 | 55 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 22 / 1100989 | 19 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 5 / 149255 | 33 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 6 / 215722 | 27 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 7 / 211054 | 33 | |
| heart | 2 / 89626 | 22 | |
| intestine | 3 / 234472 | 12 | |
| kidney | 5 / 211777 | 23 | |
| larynx | 0 / 24145 | 0 | |
| liver | 1 / 207743 | 4 | |
| lung | 9 / 336974 | 26 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 1 / 91610 | 10 | |
| mammary gland | 1 / 153271 | 6 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 7 / 214812 | 32 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 3 / 280825 | 10 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 3 / 53952 | 55 | |
| stomach | 1 / 96619 | 10 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 7 / 232878 | 30 | |
| vascular | 1 / 51780 | 19 | |
Microarray in - Probe name: CUST_15943_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 7.49 ± 0.7 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 6.85 ± 0.19 | |
| Basal Part of Pons | 6.93 ± 0.3 | |
| Cerebellar Cortex | 7.01 ± 0.4 | |
| Cerebellar Nuclei | 6.57 ± 0.34 | |
| Claustrum | 7.71 ± 0.83 | |
| Epithalamus | 6.12 ± 0.35 | |
| Frontal Lobe | 6.75 ± 0.48 | |
| Globus Pallidus | 6.83 ± 0.48 | |
| Hypothalamus | 6.18 ± 0.24 | |
| Insula | 6.87 ± 0.42 | |
| Limbic Lobe | 7.32 ± 0.69 | |
| Mesencephalon | 6.76 ± 0.51 | |
| Myelencephalon | 7.03 ± 0.62 | |
| Occipital Lobe | 7.45 ± 0.67 | |
| Parietal Lobe | 6.95 ± 0.56 | |
| Pontine Tegmentum | 6.83 ± 0.5 | |
| Striatum | 7.5 ± 0.63 | |
| Subthalamus | 6.54 ± 0.22 | |
| Temporal Lobe | 6.94 ± 0.5 | |
| Thalamus | 7.24 ± 0.54 | |
| White Matter | 6.63 ± 0.27 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Shank3 | CB | Cerebellum | 0 | |
| 0 | | |||
| Shank3 | CTX | Cerebral cortex | 0 | |
| 0 | | |||
| Shank3 | HIP | Hippocampal region | 0 | |
| 0 | | |||
| Shank3 | HPF | Hippocampal formation | 0 | |
| 0 | | |||
| Shank3 | HY | Hypothalamus | 0 | |
| 0 | | |||
| Shank3 | LSX | Lateral septal complex | 0 | |
| 0 | | |||
| Shank3 | MB | Midbrain | 0 | |
| 0 | | |||
| Shank3 | MY | Medulla | 0 | |
| 0 | | |||
| Shank3 | OLF | Olfactory bulb | 0 | |
| 0 | | |||
| Shank3 | P | Pons | 0 | |
| 0 | | |||
| Shank3 | PAL | Pallidum | 0 | |
| 0 | | |||
| Shank3 | RHP | Retrohippocampal region | 0 | |
| 0 | | |||
| Shank3 | sAMY | Striatum-like amygdalar nuclei | 0 | |
| 0 | | |||
| Shank3 | STR | Striatum | 0 | |
| 0 | | |||
| Shank3 | STRd | Striatum dorsal region | 0 | |
| 0 | | |||
| Shank3 | STRv | Striatum ventral region | 0 | |
| 0 | | |||
| Shank3 | TH | Thalamus | 0 | |
| 0 | |