AutismKB 2.0

Annotation Detail for SYDE1


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Basic Information Top
Gene Symbol:SYDE1 ( 7h3,FLJ13511 )
Gene Full Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
Band: 19p13.12
Quick LinksEntrez ID:85360; OMIM: NA; Uniprot ID:SYDE1_HUMAN; ENSEMBL ID: ENSG00000105137; HGNC ID: 25824
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus14 / 56401224
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult72 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor3 / 3436687
chondrosarcoma9 / 82823108
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma9 / 10688384
head and neck tumor7 / 13630251
kidney tumor3 / 6895943
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal99 / 336030729
ovarian tumor1 / 7668213
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone9 / 71655125
bone marrow0 / 488010 
brain23 / 110098920
cervix3 / 4817162
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye5 / 21105423
heart4 / 8962644
intestine2 / 2344728
kidney11 / 21177751
larynx0 / 241450 
liver1 / 2077434
lung10 / 33697429
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta35 / 280825124
prostate3 / 18934515
salivary gland3 / 20155148
skin12 / 21057456
spleen1 / 5395218
stomach0 / 966190 
testis2 / 3304426
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus13 / 23287855
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 216271_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts3.85
Adipocyte2.95
AdrenalCortex3
Adrenalgland2.55
Amygdala3.2
Appendix3
AtrioventricularNode2.2
BDCA4+_DentriticCells3.4
Bonemarrow2.9
BronchialEpithelialCells2.95
CD105+_Endothelial3.05
CD14+_Monocytes3.2
CD19+_BCells(neg._sel.)3.25
CD33+_Myeloid3.9
CD34+3.85
CD4+_Tcells3.35
CD56+_NKCells3.65
CD71+_EarlyErythroid2.8
CD8+_Tcells2.95
CardiacMyocytes3.75
Caudatenucleus2.7
Cerebellum2.45
CerebellumPeduncles3.35
CiliaryGanglion2.05
CingulateCortex3.05
Colorectaladenocarcinoma3
DorsalRootGanglion2.25
FetalThyroid2.95
Fetalbrain3
Fetalliver3.3
Fetallung2.55
GlobusPallidus2.15
Heart3.8
Hypothalamus3.3
Kidney2.4
Leukemia_chronicMyelogenousK-5622.75
Leukemia_promyelocytic-HL-602.65
Leukemialymphoblastic(MOLT-4)2.45
Liver3.95
Lung3.35
Lymphnode2.6
Lymphoma_burkitts(Daudi)3.8
Lymphoma_burkitts(Raji)4.15
MedullaOblongata2.75
OccipitalLobe2.7
OlfactoryBulb2.35
Ovary1.95
Pancreas2.4
PancreaticIslet3.2
ParietalLobe3.1
Pituitary3.5
Placenta3.25
Pons2.85
PrefrontalCortex3.8
Prostate3.55
Salivarygland2.4
SkeletalMuscle3.45
Skin2.25
SmoothMuscle3.4
Spinalcord3.2
SubthalamicNucleus2.7
SuperiorCervicalGanglion3.3
TemporalLobe2.7
Testis2.6
TestisGermCell2.55
TestisIntersitial2.5
TestisLeydigCell2.95
TestisSeminiferousTubule2.6
Thalamus3.05
Thymus2.4
Thyroid3.8
Tongue2.9
Tonsil2.95
Trachea2.55
TrigeminalGanglion2.9
Uterus2.5
UterusCorpus2.65
WholeBlood3.3
Wholebrain2.65
colon3.05
pineal_day3.76
pineal_night3.66
retina3.625
small_intestine2.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_1989_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.63 ± 0.74
Basal Forebrain5.37 ± 0.29
Basal Part of Pons5.43 ± 0.5
Cerebellar Cortex4.92 ± 0.24
Cerebellar Nuclei5.64 ± 0.49
Claustrum5.71 ± 0.58
Epithalamus4.51 ± 0.55
Frontal Lobe5.27 ± 0.53
Globus Pallidus5.81 ± 0.44
Hypothalamus4.94 ± 0.65
Insula5.16 ± 0.41
Limbic Lobe5.32 ± 0.52
Mesencephalon5.4 ± 0.51
Myelencephalon5.34 ± 0.58
Occipital Lobe5.38 ± 0.59
Parietal Lobe5.3 ± 0.47
Pontine Tegmentum5.36 ± 0.44
Striatum5.69 ± 0.6
Subthalamus5.37 ± 0.27
Temporal Lobe5.23 ± 0.59
Thalamus5.56 ± 0.4
White Matter5.38 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Syde1CBCerebellum9.32
15.06
Syde1CTXCerebral cortex2.77
2.62
Syde1HIPHippocampal region3.42
4.05
Syde1HPFHippocampal formation2.96
3.77
Syde1HYHypothalamus0.82
0.87
Syde1LSXLateral septal complex0.25
0.32
Syde1MBMidbrain1.5
2.17
Syde1MYMedulla4.7
5.46
Syde1OLFOlfactory bulb6
5.02
Syde1PPons3.65
4.27
Syde1PALPallidum2.77
2.57
Syde1RHPRetrohippocampal region1.62
2.38
Syde1sAMYStriatum-like amygdalar nuclei6.09
4.6
Syde1STRStriatum3
2.61
Syde1STRdStriatum dorsal region2.39
2.25
Syde1STRvStriatum ventral region4.95
3.79
Syde1THThalamus2.29
2.08
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00501178 36 30 65 GHPAQRPEPSPPEPEPQAPEGSQAGAEGPSSPEASR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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