AutismKB 2.0

Annotation Detail for TRIM5


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Basic Information Top
Gene Symbol:TRIM5 ( RNF88,TRIM5alpha )
Gene Full Name: tripartite motif-containing 5
Band: 11p15.4
Quick LinksEntrez ID:85363; OMIM: 608487; Uniprot ID:TRIM5_HUMAN; ENSEMBL ID: ENSG00000132256; HGNC ID: 16276
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus10 / 56401217
neonate3 / 3109796
infant0 / 236200 
juvenile0 / 555560 
adult63 / 193912132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor7 / 9417874
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor10 / 26384537
glioma3 / 10688328
head and neck tumor4 / 13630229
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal77 / 336030722
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor21 / 90257232
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder3 / 29757100
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain16 / 110098914
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye5 / 21105423
heart2 / 8962622
intestine3 / 23447212
kidney8 / 21177737
larynx0 / 241450 
liver5 / 20774324
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth4 / 6705259
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta7 / 28082524
prostate7 / 18934536
salivary gland0 / 201550 
skin7 / 21057433
spleen1 / 5395218
stomach1 / 9661910
testis7 / 33044221
thymus11 / 81131135
thyroid3 / 4747363
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus23 / 23287898
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210705_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.25
Adipocyte12.2
AdrenalCortex17.4
Adrenalgland11.1
Amygdala9.6
Appendix21.8
AtrioventricularNode21.65
BDCA4+_DentriticCells20.05
Bonemarrow14.95
BronchialEpithelialCells11.95
CD105+_Endothelial12.7
CD14+_Monocytes22.95
CD19+_BCells(neg._sel.)17.6
CD33+_Myeloid28.7
CD34+18.8
CD4+_Tcells12.85
CD56+_NKCells19.85
CD71+_EarlyErythroid11.8
CD8+_Tcells18.35
CardiacMyocytes21.65
Caudatenucleus9.5
Cerebellum8.75
CerebellumPeduncles14.45
CiliaryGanglion17.7
CingulateCortex12.3
Colorectaladenocarcinoma10.1
DorsalRootGanglion16.55
FetalThyroid13.55
Fetalbrain11.4
Fetalliver10.5
Fetallung10.45
GlobusPallidus9.5
Heart20.2
Hypothalamus10.55
Kidney11.45
Leukemia_chronicMyelogenousK-56210.9
Leukemia_promyelocytic-HL-609.65
Leukemialymphoblastic(MOLT-4)9.65
Liver17.45
Lung13.55
Lymphnode10.45
Lymphoma_burkitts(Daudi)15.75
Lymphoma_burkitts(Raji)19.75
MedullaOblongata8.85
OccipitalLobe10.4
OlfactoryBulb9.2
Ovary11.35
Pancreas12.95
PancreaticIslet32.4
ParietalLobe13.6
Pituitary13.3
Placenta11.9
Pons11.6
PrefrontalCortex12
Prostate26.3
Salivarygland14.1
SkeletalMuscle17.75
Skin18.8
SmoothMuscle25
Spinalcord11.55
SubthalamicNucleus12.2
SuperiorCervicalGanglion29.25
TemporalLobe11.4
Testis9.3
TestisGermCell9.4
TestisIntersitial10.25
TestisLeydigCell12.9
TestisSeminiferousTubule10.05
Thalamus12.65
Thymus9.1
Thyroid15.15
Tongue15
Tonsil12.45
Trachea9.35
TrigeminalGanglion27.25
Uterus21.65
UterusCorpus15.35
WholeBlood15.25
Wholebrain7.4
colon14.45
pineal_day12.18
pineal_night12.42
retina13.85
small_intestine16.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13821_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.72 ± 0.73
Basal Forebrain3.56 ± 0.57
Basal Part of Pons3.89 ± 0.43
Cerebellar Cortex3.35 ± 0.5
Cerebellar Nuclei4.2 ± 0.65
Claustrum4.03 ± 0.76
Epithalamus4.61 ± 0.65
Frontal Lobe3.78 ± 0.65
Globus Pallidus4.86 ± 0.41
Hypothalamus3.81 ± 0.41
Insula3.67 ± 0.74
Limbic Lobe3.84 ± 0.65
Mesencephalon3.88 ± 0.64
Myelencephalon3.97 ± 0.62
Occipital Lobe3.89 ± 0.64
Parietal Lobe3.79 ± 0.64
Pontine Tegmentum3.89 ± 0.82
Striatum4.23 ± 0.58
Subthalamus3.66 ± 0.55
Temporal Lobe3.76 ± 0.69
Thalamus3.93 ± 0.55
White Matter4.31 ± 0.56
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
TRIM5_HUMAN_213 17 213 229 SLTNSETEMVQQTQSLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018