AutismKB 2.0

Annotation Detail for PIR


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Basic Information Top
Gene Symbol:PIR ( - )
Gene Full Name: pirin (iron-binding nuclear protein)
Band: Xp22.2
Quick LinksEntrez ID:8544; OMIM: 603329; Uniprot ID:PIR_HUMAN; ENSEMBL ID: ENSG00000087842; HGNC ID: 30048
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor3 / 3436687
chondrosarcoma4 / 8282348
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor8 / 26384530
glioma5 / 10688346
head and neck tumor3 / 13630222
kidney tumor3 / 6895943
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor16 / 103127155
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal80 / 336030723
ovarian tumor1 / 7668213
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS15 / 125680119
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor21 / 124949168
soft tissue/muscle tissue tumor41 / 125191327
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow2 / 4880140
brain19 / 110098917
cervix5 / 48171103
connective tissue43 / 149255288
ear0 / 162120 
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye5 / 21105423
heart1 / 8962611
intestine7 / 23447229
kidney13 / 21177761
larynx0 / 241450 
liver5 / 20774324
lung33 / 33697497
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta8 / 28082528
prostate5 / 18934526
salivary gland3 / 20155148
skin24 / 210574113
spleen0 / 539520 
stomach2 / 9661920
testis2 / 3304426
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207469_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts74.6
Adipocyte13.9
AdrenalCortex8.4
Adrenalgland7.1
Amygdala8.55
Appendix7.7
AtrioventricularNode6.9
BDCA4+_DentriticCells7
Bonemarrow7.35
BronchialEpithelialCells113.5
CD105+_Endothelial30.4
CD14+_Monocytes7.35
CD19+_BCells(neg._sel.)7
CD33+_Myeloid8.55
CD34+10.7
CD4+_Tcells7.1
CD56+_NKCells7.75
CD71+_EarlyErythroid8.25
CD8+_Tcells6.2
CardiacMyocytes13.4
Caudatenucleus6.55
Cerebellum5.8
CerebellumPeduncles8.65
CiliaryGanglion5.85
CingulateCortex7.55
Colorectaladenocarcinoma30.55
DorsalRootGanglion5.6
FetalThyroid7.3
Fetalbrain6.5
Fetalliver6.15
Fetallung5.8
GlobusPallidus5.4
Heart11
Hypothalamus17.15
Kidney6.15
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-605.95
Leukemialymphoblastic(MOLT-4)5.25
Liver10.1
Lung13.2
Lymphnode5.75
Lymphoma_burkitts(Daudi)9
Lymphoma_burkitts(Raji)10.5
MedullaOblongata9.55
OccipitalLobe7.2
OlfactoryBulb11.65
Ovary5
Pancreas5.6
PancreaticIslet7.85
ParietalLobe8
Pituitary8.45
Placenta7.75
Pons7.1
PrefrontalCortex12.8
Prostate8.55
Salivarygland6
SkeletalMuscle10.1
Skin6.15
SmoothMuscle20.65
Spinalcord27.1
SubthalamicNucleus6.45
SuperiorCervicalGanglion9.35
TemporalLobe6.6
Testis6
TestisGermCell5.75
TestisIntersitial5.85
TestisLeydigCell7.1
TestisSeminiferousTubule5.85
Thalamus7.7
Thymus5.15
Thyroid11.95
Tongue8.95
Tonsil6.85
Trachea9.65
TrigeminalGanglion8.15
Uterus8.3
UterusCorpus7.1
WholeBlood7.45
Wholebrain7.1
colon8.4
pineal_day32.42
pineal_night19.02
retina82.55
small_intestine7.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_952_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.54 ± 0.32
Basal Forebrain7.73 ± 0.19
Basal Part of Pons7.37 ± 0.25
Cerebellar Cortex7.3 ± 0.16
Cerebellar Nuclei7.96 ± 0.54
Claustrum7.34 ± 0.33
Epithalamus8.37 ± 0.38
Frontal Lobe7.62 ± 0.35
Globus Pallidus8.74 ± 0.25
Hypothalamus7.89 ± 0.35
Insula7.51 ± 0.29
Limbic Lobe7.37 ± 0.36
Mesencephalon7.89 ± 0.36
Myelencephalon7.7 ± 0.39
Occipital Lobe7.58 ± 0.36
Parietal Lobe7.65 ± 0.37
Pontine Tegmentum7.81 ± 0.23
Striatum8.25 ± 0.33
Subthalamus7.79 ± 0.38
Temporal Lobe7.5 ± 0.25
Thalamus7.84 ± 0.3
White Matter8.99 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PirCBCerebellum5.14
7.59
PirCTXCerebral cortex6.43
5.45
PirHIPHippocampal region2.89
2.96
PirHPFHippocampal formation2.82
2.88
PirHYHypothalamus0.72
0.8
PirLSXLateral septal complex0.92
0.74
PirMBMidbrain3.21
3.98
PirMYMedulla8.59
12.19
PirOLFOlfactory bulb7.13
6.22
PirPPons6.82
9.1
PirPALPallidum1.78
1.89
PirRHPRetrohippocampal region2.78
2.67
PirsAMYStriatum-like amygdalar nuclei0.17
0.21
PirSTRStriatum1.09
0.87
PirSTRdStriatum dorsal region0.76
0.56
PirSTRvStriatum ventral region2.64
2.05
PirTHThalamus1.32
1.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00131592 12 35 46 NLDPFLLFDEFK Peptide Atlas
PIR_HUMAN_0 0 0 0 NLDPFLLFDEFK PRIDE
PIR_HUMAN_125 10 125 134 MVEPQYQELK PRIDE
PIR_HUMAN_2 13 2 14 GSSKKVTLSVLSR PRIDE
PIR_HUMAN_211 23 211 233 IEPHHTAVLGEGDSVQVENKDPK PRIDE
PIR_HUMAN_211 24 211 234 IEPHHTAVLGEGDSVQVENKDPKR PRIDE
PIR_HUMAN_34 12 34 45 NLDPFLLFDEFK PRIDE
PIR_HUMAN_34 25 34 58 NLDPFLLFDEFKGGRPGGFPDHPHR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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