AutismKB 2.0

Annotation Detail for PIAS1


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Basic Information Top
Gene Symbol:PIAS1 ( DDXBP1,GBP,GU/RH-II,MGC141878,MGC141879,ZMIZ3 )
Gene Full Name: protein inhibitor of activated STAT, 1
Band: 15q23
Quick LinksEntrez ID:8554; OMIM: 603566; Uniprot ID:PIAS1_HUMAN; ENSEMBL ID: ENSG00000033800; HGNC ID: 2752
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus41 / 56401272
neonate2 / 3109764
infant1 / 2362042
juvenile7 / 55556125
adult93 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor9 / 9417895
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor25 / 26384594
glioma3 / 10688328
head and neck tumor11 / 13630280
kidney tumor3 / 6895943
leukemia7 / 9584273
liver tumor8 / 9635983
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia7 / 9725071
normal173 / 336030751
ovarian tumor3 / 7668239
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer3 / 10268029
retinoblastoma5 / 46356107
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder3 / 29757100
blood11 / 12347889
bone3 / 7165541
bone marrow5 / 48801102
brain57 / 110098951
cervix0 / 481710 
connective tissue3 / 14925520
ear2 / 16212123
embryonic tissue8 / 21572237
esophagus1 / 2020949
eye7 / 21105433
heart7 / 8962678
intestine6 / 23447225
kidney10 / 21177747
larynx2 / 2414582
liver11 / 20774352
lung21 / 33697462
lymph2 / 4427045
lymph node9 / 9161098
mammary gland14 / 15327191
mouth5 / 6705274
muscle1 / 1077159
nerve1 / 1576863
ovary5 / 10205148
pancreas23 / 214812107
parathyroid1 / 2053948
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta9 / 28082532
prostate7 / 18934536
salivary gland0 / 201550 
skin5 / 21057423
spleen3 / 5395255
stomach2 / 9661920
testis29 / 33044287
thymus6 / 8113173
thyroid4 / 4747384
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus14 / 23287860
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217864_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts144.45
Adipocyte34.95
AdrenalCortex46.65
Adrenalgland33.2
Amygdala40.4
Appendix43.9
AtrioventricularNode28.8
BDCA4+_DentriticCells127.15
Bonemarrow44
BronchialEpithelialCells36.2
CD105+_Endothelial46.95
CD14+_Monocytes164.4
CD19+_BCells(neg._sel.)145.4
CD33+_Myeloid262.3
CD34+108.4
CD4+_Tcells163.95
CD56+_NKCells139.15
CD71+_EarlyErythroid32.8
CD8+_Tcells143.3
CardiacMyocytes49.6
Caudatenucleus24.65
Cerebellum28.25
CerebellumPeduncles49.3
CiliaryGanglion25.95
CingulateCortex47.75
Colorectaladenocarcinoma24
DorsalRootGanglion33.4
FetalThyroid44.9
Fetalbrain33.4
Fetalliver34.5
Fetallung32.9
GlobusPallidus30.85
Heart40.85
Hypothalamus35.85
Kidney27.9
Leukemia_chronicMyelogenousK-56227.45
Leukemia_promyelocytic-HL-6039.4
Leukemialymphoblastic(MOLT-4)35.8
Liver37.15
Lung32.95
Lymphnode38.4
Lymphoma_burkitts(Daudi)53.4
Lymphoma_burkitts(Raji)57.35
MedullaOblongata41
OccipitalLobe46.85
OlfactoryBulb63.4
Ovary29.25
Pancreas35.35
PancreaticIslet51.25
ParietalLobe59.85
Pituitary51.85
Placenta43.3
Pons37.5
PrefrontalCortex65.6
Prostate57.1
Salivarygland27.7
SkeletalMuscle44.35
Skin33.9
SmoothMuscle40.4
Spinalcord22.4
SubthalamicNucleus36.75
SuperiorCervicalGanglion48.8
TemporalLobe40.2
Testis39.6
TestisGermCell72.9
TestisIntersitial58.85
TestisLeydigCell44.2
TestisSeminiferousTubule65.65
Thalamus24.45
Thymus52.05
Thyroid42.85
Tongue49.3
Tonsil77.65
Trachea37.3
TrigeminalGanglion35.1
Uterus36.3
UterusCorpus39.25
WholeBlood89.85
Wholebrain33.5
colon46.6
pineal_day178.3
pineal_night163.92
retina51.325
small_intestine43.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P163353
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.84 ± 0.29
Basal Forebrain7.51 ± 0.17
Basal Part of Pons7.69 ± 0.33
Cerebellar Cortex7.77 ± 0.21
Cerebellar Nuclei7.4 ± 0.2
Claustrum7.77 ± 0.34
Epithalamus7.65 ± 0.21
Frontal Lobe7.46 ± 0.33
Globus Pallidus7.2 ± 0.24
Hypothalamus7.45 ± 0.41
Insula7.56 ± 0.44
Limbic Lobe7.68 ± 0.3
Mesencephalon7.52 ± 0.3
Myelencephalon7.53 ± 0.33
Occipital Lobe7.78 ± 0.29
Parietal Lobe7.54 ± 0.26
Pontine Tegmentum7.55 ± 0.27
Striatum7.64 ± 0.27
Subthalamus7.28 ± 0.19
Temporal Lobe7.53 ± 0.3
Thalamus7.35 ± 0.27
White Matter7.43 ± 0.27
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pias1CBCerebellum9.17
9.02
Pias1CTXCerebral cortex38.73
26.13
Pias1HIPHippocampal region36.38
52.51
Pias1HPFHippocampal formation33.39
38.26
Pias1HYHypothalamus3.52
2.48
Pias1LSXLateral septal complex15.47
10.19
Pias1MBMidbrain3.76
3.66
Pias1MYMedulla4.2
4.07
Pias1OLFOlfactory bulb41.85
32.98
Pias1PPons3.62
3.05
Pias1PALPallidum8.97
7.13
Pias1RHPRetrohippocampal region29.38
21.76
Pias1sAMYStriatum-like amygdalar nuclei20.67
14.26
Pias1STRStriatum28.2
18.95
Pias1STRdStriatum dorsal region29.89
20.3
Pias1STRvStriatum ventral region27.1
17.34
Pias1THThalamus7.14
5.52
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00503681 21 508 528 TPSLPAVDTSYINTSLIQDYR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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