AutismKB 2.0

Annotation Detail for PRPF18


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PRPF18 ( FLJ10210,PRP18,hPrp18 )
Gene Full Name: PRP18 pre-mRNA processing factor 18 homolog (S. cerevisiae)
Band: 10p13
Quick LinksEntrez ID:8559; OMIM: 604993; Uniprot ID:PRP18_HUMAN; ENSEMBL ID: ENSG00000165630; HGNC ID: 17351
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus38 / 56401267
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor4 / 11424635
esophageal tumor2 / 17290115
gastrointestinal tumor2 / 11936916
germ cell tumor8 / 26384530
glioma7 / 10688365
head and neck tumor8 / 13630258
kidney tumor5 / 6895972
leukemia5 / 9584252
liver tumor4 / 9635941
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal149 / 336030744
ovarian tumor8 / 76682104
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer2 / 10268019
retinoblastoma3 / 4635664
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites2 / 4001549
bladder2 / 2975767
blood3 / 12347824
bone10 / 71655139
bone marrow3 / 4880161
brain51 / 110098946
cervix0 / 481710 
connective tissue1 / 1492556
ear3 / 16212185
embryonic tissue9 / 21572241
esophagus2 / 2020998
eye15 / 21105471
heart3 / 8962633
intestine14 / 23447259
kidney19 / 21177789
larynx1 / 2414541
liver22 / 207743105
lung14 / 33697441
lymph0 / 442700 
lymph node4 / 9161043
mammary gland2 / 15327113
mouth2 / 6705229
muscle8 / 10771574
nerve0 / 157680 
ovary8 / 10205178
pancreas0 / 2148120 
parathyroid3 / 20539146
pharynx8 / 41328193
pituitary gland1 / 1658560
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin4 / 21057418
spleen2 / 5395237
stomach3 / 9661931
testis15 / 33044245
thymus3 / 8113136
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221547_at
Cell line Expression level Expression bar
721_B_lymphoblasts33.6
Adipocyte13.55
AdrenalCortex10.2
Adrenalgland8.65
Amygdala22.6
Appendix13.5
AtrioventricularNode10.1
BDCA4+_DentriticCells123.3
Bonemarrow14.65
BronchialEpithelialCells34.6
CD105+_Endothelial89.1
CD14+_Monocytes165.6
CD19+_BCells(neg._sel.)186.2
CD33+_Myeloid101.75
CD34+55.5
CD4+_Tcells104.6
CD56+_NKCells217.65
CD71+_EarlyErythroid125.75
CD8+_Tcells103.55
CardiacMyocytes20.9
Caudatenucleus10.7
Cerebellum7.95
CerebellumPeduncles13.8
CiliaryGanglion7.85
CingulateCortex12.35
Colorectaladenocarcinoma16.6
DorsalRootGanglion10.75
FetalThyroid12.4
Fetalbrain13.75
Fetalliver30.95
Fetallung15.8
GlobusPallidus7.95
Heart28.65
Hypothalamus14.45
Kidney10.25
Leukemia_chronicMyelogenousK-56211.45
Leukemia_promyelocytic-HL-6012.2
Leukemialymphoblastic(MOLT-4)21.8
Liver16.85
Lung9.5
Lymphnode11.7
Lymphoma_burkitts(Daudi)14.85
Lymphoma_burkitts(Raji)17.85
MedullaOblongata8.75
OccipitalLobe11.35
OlfactoryBulb10.1
Ovary9.9
Pancreas11.25
PancreaticIslet27
ParietalLobe12.9
Pituitary13.95
Placenta14.05
Pons11.45
PrefrontalCortex14.7
Prostate17
Salivarygland10.8
SkeletalMuscle15.05
Skin10.2
SmoothMuscle31.9
Spinalcord8.75
SubthalamicNucleus26.25
SuperiorCervicalGanglion13.85
TemporalLobe14.3
Testis13.55
TestisGermCell16.45
TestisIntersitial36.85
TestisLeydigCell42.8
TestisSeminiferousTubule22.75
Thalamus13.1
Thymus9.95
Thyroid29.25
Tongue16.2
Tonsil11.55
Trachea14.15
TrigeminalGanglion21.15
Uterus15
UterusCorpus15.15
WholeBlood75.9
Wholebrain13.95
colon43.95
pineal_day19.5
pineal_night16.7
retina14.425
small_intestine27.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6655_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.16 ± 0.36
Basal Forebrain7.09 ± 0.17
Basal Part of Pons6.92 ± 0.12
Cerebellar Cortex7.18 ± 0.21
Cerebellar Nuclei7.21 ± 0.26
Claustrum7.03 ± 0.35
Epithalamus7.18 ± 0.17
Frontal Lobe6.99 ± 0.25
Globus Pallidus7.33 ± 0.16
Hypothalamus7.09 ± 0.34
Insula6.96 ± 0.24
Limbic Lobe7.08 ± 0.26
Mesencephalon7.07 ± 0.35
Myelencephalon7.01 ± 0.25
Occipital Lobe7.18 ± 0.22
Parietal Lobe7.11 ± 0.25
Pontine Tegmentum7.13 ± 0.22
Striatum7.02 ± 0.28
Subthalamus7.3 ± 0.07
Temporal Lobe7.07 ± 0.24
Thalamus6.91 ± 0.25
White Matter7.52 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prpf18CBCerebellum54.15
65.33
Prpf18CTXCerebral cortex100
96.16
Prpf18HIPHippocampal region61.07
95.54
Prpf18HPFHippocampal formation71.48
86.62
Prpf18HYHypothalamus70.5
54.34
Prpf18LSXLateral septal complex68.87
49.55
Prpf18MBMidbrain71.2
64.26
Prpf18MYMedulla66.07
70.91
Prpf18OLFOlfactory bulb86.47
77.99
Prpf18PPons58.29
60.73
Prpf18PALPallidum51.77
45.45
Prpf18RHPRetrohippocampal region87.59
76.67
Prpf18sAMYStriatum-like amygdalar nuclei51.96
37.4
Prpf18STRStriatum71.32
52.17
Prpf18STRdStriatum dorsal region69.22
51.11
Prpf18STRvStriatum ventral region88.89
62.62
Prpf18THThalamus73.74
62.33
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069853 12 301 312 HVAHVLNDETQR Peptide Atlas
PRP18_HUMAN_1 10 1 10 MDILKSEILR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved