AutismKB 2.0

Annotation Detail for DENR


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Basic Information Top
Gene Symbol:DENR ( DRP,DRP1,SMAP-3 )
Gene Full Name: density-regulated protein
Band: 12q24.31
Quick LinksEntrez ID:8562; OMIM: 604550; Uniprot ID:DENR_HUMAN; ENSEMBL ID: ENSG00000139726; HGNC ID: 2769
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst8 / 62319128
fetus20 / 56401235
neonate3 / 3109796
infant1 / 2362042
juvenile1 / 5555617
adult110 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor5 / 9417853
cervical tumor3 / 3436687
chondrosarcoma5 / 8282360
colorectal tumor9 / 11424678
esophageal tumor1 / 1729057
gastrointestinal tumor9 / 11936975
germ cell tumor25 / 26384594
glioma5 / 10688346
head and neck tumor9 / 13630266
kidney tumor7 / 68959101
leukemia3 / 9584231
liver tumor5 / 9635951
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal170 / 336030750
ovarian tumor5 / 7668265
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer4 / 10268038
retinoblastoma2 / 4635643
skin tumor7 / 12494956
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites4 / 4001599
bladder6 / 29757201
blood3 / 12347824
bone3 / 7165541
bone marrow3 / 4880161
brain38 / 110098934
cervix3 / 4817162
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue36 / 215722166
esophagus1 / 2020949
eye13 / 21105461
heart6 / 8962666
intestine15 / 23447263
kidney10 / 21177747
larynx2 / 2414582
liver7 / 20774333
lung11 / 33697432
lymph0 / 442700 
lymph node5 / 9161054
mammary gland10 / 15327165
mouth6 / 6705289
muscle7 / 10771564
nerve1 / 1576863
ovary5 / 10205148
pancreas12 / 21481255
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta15 / 28082553
prostate9 / 18934547
salivary gland0 / 201550 
skin12 / 21057456
spleen0 / 539520 
stomach3 / 9661931
testis20 / 33044260
thymus2 / 8113124
thyroid1 / 4747321
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus14 / 23287860
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221509_at
Cell line Expression level Expression bar
721_B_lymphoblasts351.9
Adipocyte77.75
AdrenalCortex44.9
Adrenalgland31.75
Amygdala162.85
Appendix40.15
AtrioventricularNode18.1
BDCA4+_DentriticCells324.45
Bonemarrow48.75
BronchialEpithelialCells128
CD105+_Endothelial262.75
CD14+_Monocytes177.8
CD19+_BCells(neg._sel.)374.05
CD33+_Myeloid264.4
CD34+537.85
CD4+_Tcells111.75
CD56+_NKCells452.35
CD71+_EarlyErythroid66.45
CD8+_Tcells170.1
CardiacMyocytes92.1
Caudatenucleus46.3
Cerebellum26.25
CerebellumPeduncles48.1
CiliaryGanglion28.2
CingulateCortex56.4
Colorectaladenocarcinoma163.65
DorsalRootGanglion31.6
FetalThyroid80.2
Fetalbrain64.75
Fetalliver53.3
Fetallung67.25
GlobusPallidus39.2
Heart35.15
Hypothalamus116.15
Kidney17.7
Leukemia_chronicMyelogenousK-562118.2
Leukemia_promyelocytic-HL-6087.4
Leukemialymphoblastic(MOLT-4)120.65
Liver42.9
Lung33.65
Lymphnode66.2
Lymphoma_burkitts(Daudi)102.05
Lymphoma_burkitts(Raji)108.25
MedullaOblongata37
OccipitalLobe56.95
OlfactoryBulb47.4
Ovary33.05
Pancreas76.65
PancreaticIslet59.3
ParietalLobe51.1
Pituitary66.25
Placenta59
Pons32.75
PrefrontalCortex170
Prostate136.75
Salivarygland40.3
SkeletalMuscle46
Skin43
SmoothMuscle117.1
Spinalcord58.5
SubthalamicNucleus52.2
SuperiorCervicalGanglion46.4
TemporalLobe46.35
Testis32.6
TestisGermCell68.5
TestisIntersitial46.15
TestisLeydigCell50.8
TestisSeminiferousTubule43.4
Thalamus52.05
Thymus48.55
Thyroid285.85
Tongue55.55
Tonsil57.05
Trachea39.8
TrigeminalGanglion24.55
Uterus116.8
UterusCorpus43.4
WholeBlood72.8
Wholebrain73.95
colon216.95
pineal_day104.38
pineal_night117.78
retina60.6
small_intestine230.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P162256
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.62 ± 0.28
Basal Forebrain5.61 ± 0.36
Basal Part of Pons5.8 ± 0.28
Cerebellar Cortex5.95 ± 0.21
Cerebellar Nuclei5.67 ± 0.64
Claustrum5.54 ± 0.66
Epithalamus5.82 ± 0.33
Frontal Lobe5.91 ± 0.37
Globus Pallidus5.37 ± 0.42
Hypothalamus6.22 ± 0.4
Insula5.88 ± 0.29
Limbic Lobe5.72 ± 0.44
Mesencephalon5.9 ± 0.59
Myelencephalon5.73 ± 0.47
Occipital Lobe5.35 ± 0.42
Parietal Lobe5.87 ± 0.4
Pontine Tegmentum5.68 ± 0.45
Striatum5.03 ± 0.39
Subthalamus6.01 ± 0.33
Temporal Lobe5.88 ± 0.28
Thalamus5.63 ± 0.37
White Matter5.25 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
DenrCBCerebellum21.63
25.31
DenrCTXCerebral cortex72.17
58.13
DenrHIPHippocampal region44.16
61.96
DenrHPFHippocampal formation46.02
53.23
DenrHYHypothalamus31.18
27.22
DenrLSXLateral septal complex14.2
10.85
DenrMBMidbrain36.19
34.01
DenrMYMedulla47.22
57.41
DenrOLFOlfactory bulb50.99
42.72
DenrPPons36.91
42.38
DenrPALPallidum42.48
41.95
DenrRHPRetrohippocampal region51.71
40.61
DenrsAMYStriatum-like amygdalar nuclei65.65
53.12
DenrSTRStriatum28.67
22.13
DenrSTRdStriatum dorsal region24.82
18.94
DenrSTRvStriatum ventral region29.9
21.91
DenrTHThalamus43.41
38.27
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
DENR_HUMAN_123 8 123 130 AKKKYVTR PRIDE
DENR_HUMAN_2 17 2 18 AADISESSGADCKGDPR PRIDE
DENR_HUMAN_75 20 75 94 QEAGISEGQGTAGEEEEKKK PRIDE
PAp00039045 17 182 198 WPEVDDDSIEDLGEVKK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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