AutismKB 2.0

Annotation Detail for PRKRA


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Basic Information Top
Gene Symbol:PRKRA ( DYT16,PACT,RAX )
Gene Full Name: protein kinase, interferon-inducible double stranded RNA dependent activator
Band: 2q31.2
Quick LinksEntrez ID:8575; OMIM: 603424; Uniprot ID:PRKRA_HUMAN; ENSEMBL ID: ENSG00000180228; HGNC ID: 9438
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst1 / 6231916
fetus53 / 56401293
neonate0 / 310970 
infant2 / 2362084
juvenile2 / 5555635
adult109 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor3 / 3436687
chondrosarcoma11 / 82823132
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor15 / 26384556
glioma9 / 10688384
head and neck tumor3 / 13630222
kidney tumor2 / 6895929
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma5 / 7175569
non-neoplasia7 / 9725071
normal237 / 336030770
ovarian tumor3 / 7668239
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites1 / 4001524
bladder2 / 2975767
blood8 / 12347864
bone11 / 71655153
bone marrow3 / 4880161
brain76 / 110098969
cervix3 / 4817162
connective tissue8 / 14925553
ear1 / 1621261
embryonic tissue14 / 21572264
esophagus0 / 202090 
eye6 / 21105428
heart12 / 89626133
intestine3 / 23447212
kidney14 / 21177766
larynx1 / 2414541
liver5 / 20774324
lung15 / 33697444
lymph2 / 4427045
lymph node9 / 9161098
mammary gland1 / 1532716
mouth0 / 670520 
muscle13 / 107715120
nerve0 / 157680 
ovary4 / 10205139
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta14 / 28082549
prostate7 / 18934536
salivary gland0 / 201550 
skin12 / 21057456
spleen1 / 5395218
stomach3 / 9661931
testis49 / 330442148
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus20 / 23287885
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209139_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts142.95
Adipocyte25.95
AdrenalCortex16.1
Adrenalgland19.7
Amygdala98.4
Appendix26.8
AtrioventricularNode14.35
BDCA4+_DentriticCells134.9
Bonemarrow13.9
BronchialEpithelialCells127.2
CD105+_Endothelial23.9
CD14+_Monocytes25.65
CD19+_BCells(neg._sel.)84.6
CD33+_Myeloid23.6
CD34+103.75
CD4+_Tcells35.5
CD56+_NKCells34.85
CD71+_EarlyErythroid10.4
CD8+_Tcells59.4
CardiacMyocytes23.5
Caudatenucleus20.1
Cerebellum26
CerebellumPeduncles27.4
CiliaryGanglion18.9
CingulateCortex20.5
Colorectaladenocarcinoma56.75
DorsalRootGanglion18.1
FetalThyroid23.15
Fetalbrain39.1
Fetalliver15.6
Fetallung35.3
GlobusPallidus20.7
Heart66.25
Hypothalamus53.65
Kidney17.85
Leukemia_chronicMyelogenousK-56230.3
Leukemia_promyelocytic-HL-6075.2
Leukemialymphoblastic(MOLT-4)67.4
Liver18.65
Lung59.5
Lymphnode19.3
Lymphoma_burkitts(Daudi)85.4
Lymphoma_burkitts(Raji)72.45
MedullaOblongata16.75
OccipitalLobe35.2
OlfactoryBulb19.8
Ovary15.65
Pancreas17.25
PancreaticIslet26.2
ParietalLobe20.1
Pituitary47.8
Placenta16.4
Pons14.95
PrefrontalCortex47.05
Prostate38.35
Salivarygland28.3
SkeletalMuscle16.25
Skin15.25
SmoothMuscle44.15
Spinalcord27
SubthalamicNucleus20.55
SuperiorCervicalGanglion18.55
TemporalLobe19.95
Testis82.9
TestisGermCell83.5
TestisIntersitial38.5
TestisLeydigCell64.35
TestisSeminiferousTubule32.5
Thalamus34.1
Thymus26.1
Thyroid75.15
Tongue20.85
Tonsil20
Trachea24.6
TrigeminalGanglion20.75
Uterus69.3
UterusCorpus24.1
WholeBlood20.3
Wholebrain62.35
colon82.5
pineal_day184
pineal_night175.34
retina101.675
small_intestine54.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10004_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.91 ± 0.39
Basal Forebrain6.07 ± 0.42
Basal Part of Pons6.44 ± 0.21
Cerebellar Cortex6.5 ± 0.22
Cerebellar Nuclei6.38 ± 0.58
Claustrum5.79 ± 0.51
Epithalamus6.51 ± 0.3
Frontal Lobe6.32 ± 0.36
Globus Pallidus5.96 ± 0.24
Hypothalamus6.61 ± 0.26
Insula6.29 ± 0.39
Limbic Lobe6.1 ± 0.47
Mesencephalon6.14 ± 0.41
Myelencephalon6.16 ± 0.47
Occipital Lobe5.87 ± 0.4
Parietal Lobe6.21 ± 0.33
Pontine Tegmentum6.19 ± 0.36
Striatum5.69 ± 0.33
Subthalamus6.56 ± 0.34
Temporal Lobe6.29 ± 0.36
Thalamus6.13 ± 0.34
White Matter6.82 ± 0.3
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00008655 15 70 84 VTVGDITCTGEGTSK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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