AutismKB 2.0

Annotation Detail for TNFSF11


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Basic Information Top
Gene Symbol:TNFSF11 ( CD254,ODF,OPGL,OPTB2,RANKL,TRANCE,hRANKL2,sOdf )
Gene Full Name: tumor necrosis factor (ligand) superfamily, member 11
Band: 13q14
Quick LinksEntrez ID:8600; OMIM: 602642; Uniprot ID:TNF11_HUMAN; ENSEMBL ID: ENSG00000120659; HGNC ID: 11926
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus1 / 5640121
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult6 / 19391213
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal9 / 33603072
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver1 / 2077434
lung0 / 3369740 
lymph0 / 442700 
lymph node3 / 9161032
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211153_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.6
Adipocyte4.65
AdrenalCortex5.05
Adrenalgland4.25
Amygdala4.95
Appendix4.75
AtrioventricularNode8.1
BDCA4+_DentriticCells4.85
Bonemarrow4.8
BronchialEpithelialCells4.65
CD105+_Endothelial4.7
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)4.95
CD33+_Myeloid5.75
CD34+5.8
CD4+_Tcells5
CD56+_NKCells5.35
CD71+_EarlyErythroid4.35
CD8+_Tcells4.35
CardiacMyocytes6.5
Caudatenucleus4.2
Cerebellum3.95
CerebellumPeduncles5.45
CiliaryGanglion3.4
CingulateCortex7
Colorectaladenocarcinoma4.75
DorsalRootGanglion6.3
FetalThyroid4.6
Fetalbrain4.7
Fetalliver4.05
Fetallung3.9
GlobusPallidus3.5
Heart6
Hypothalamus5.15
Kidney3.9
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-604.95
Leukemialymphoblastic(MOLT-4)3.75
Liver6.5
Lung5.2
Lymphnode5.9
Lymphoma_burkitts(Daudi)8.4
Lymphoma_burkitts(Raji)6.8
MedullaOblongata4.7
OccipitalLobe4.25
OlfactoryBulb3.65
Ovary3.2
Pancreas3.85
PancreaticIslet4.95
ParietalLobe5.65
Pituitary5.8
Placenta4.8
Pons4.55
PrefrontalCortex5.8
Prostate5.5
Salivarygland3.85
SkeletalMuscle5.5
Skin4.1
SmoothMuscle5.6
Spinalcord5.05
SubthalamicNucleus4.3
SuperiorCervicalGanglion6.05
TemporalLobe4.3
Testis4.05
TestisGermCell3.9
TestisIntersitial4.15
TestisLeydigCell4.65
TestisSeminiferousTubule4.05
Thalamus4.8
Thymus3.75
Thyroid5.95
Tongue4.7
Tonsil6.35
Trachea3.95
TrigeminalGanglion4.8
Uterus3.9
UterusCorpus4.25
WholeBlood5.1
Wholebrain3.95
colon4.75
pineal_day5.66
pineal_night5.6
retina7.075
small_intestine4.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14596_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.26 ± 1.21
Basal Forebrain1.73 ± 0.23
Basal Part of Pons1.62 ± 0.78
Cerebellar Cortex1.52 ± 0.76
Cerebellar Nuclei2.1 ± 0.79
Claustrum2.77 ± 1.01
Epithalamus1.47 ± 0.79
Frontal Lobe1.59 ± 0.68
Globus Pallidus2.26 ± 0.36
Hypothalamus1.74 ± 0.67
Insula1.62 ± 0.4
Limbic Lobe1.83 ± 0.85
Mesencephalon1.89 ± 0.73
Myelencephalon1.76 ± 0.71
Occipital Lobe1.68 ± 0.47
Parietal Lobe1.8 ± 0.92
Pontine Tegmentum1.76 ± 0.68
Striatum1.93 ± 0.51
Subthalamus1.91 ± 0.69
Temporal Lobe1.59 ± 0.51
Thalamus1.69 ± 0.58
White Matter2.25 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tnfsf11CBCerebellum0.21
0.53
Tnfsf11LSXLateral septal complex0.23
0.1
Tnfsf11MYMedulla0.31
0.57
Tnfsf11STRdStriatum dorsal region0.14
0.23
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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