Annotation Detail for RUNX1
Basic Information Top
| Gene Symbol: | RUNX1 ( AML1,AML1-EVI-1,AMLCR1,CBFA2,EVI-1,PEBP2aB ) |
|---|---|
| Gene Full Name: | runt-related transcription factor 1 |
| Band: | 21q22.12 |
| Quick Links | Entrez ID:861; OMIM: 151385; Uniprot ID:RUNX1_HUMAN; ENSEMBL ID: ENSG00000159216; HGNC ID: 10471 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.149261
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 5 / 70761 | 70 |  |
| blastocyst | 1 / 62319 | 16 |  |
| fetus | 10 / 564012 | 17 | |
| neonate | 2 / 31097 | 64 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 115 / 1939121 | 59 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 2 / 17475 | 114 | |
| breast (mammary gland) tumor | 8 / 94178 | 84 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 11 / 82823 | 132 | |
| colorectal tumor | 8 / 114246 | 70 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 4 / 119369 | 33 | |
| germ cell tumor | 16 / 263845 | 60 | |
| glioma | 4 / 106883 | 37 | |
| head and neck tumor | 10 / 136302 | 73 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 14 / 95842 | 146 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 3 / 103127 | 29 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 2 / 97250 | 20 | |
| normal | 94 / 3360307 | 27 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 1 / 125680 | 7 |  |
| prostate cancer | 4 / 102680 | 38 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 3 / 124949 | 24 | |
| soft tissue/muscle tissue tumor | 1 / 125191 | 7 | |
| uterine tumor | 7 / 90257 | 77 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 1 / 40015 | 24 | |
| bladder | 4 / 29757 | 134 | |
| blood | 14 / 123478 | 113 | |
| bone | 5 / 71655 | 69 | |
| bone marrow | 6 / 48801 | 122 | |
| brain | 11 / 1100989 | 9 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 11 / 149255 | 73 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 6 / 215722 | 27 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 1 / 89626 | 11 | |
| intestine | 14 / 234472 | 59 | |
| kidney | 6 / 211777 | 28 | |
| larynx | 4 / 24145 | 165 | |
| liver | 2 / 207743 | 9 | |
| lung | 19 / 336974 | 56 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 3 / 91610 | 32 | |
| mammary gland | 23 / 153271 | 150 | |
| mouth | 5 / 67052 | 74 | |
| muscle | 3 / 107715 | 27 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 5 / 214812 | 23 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 2 / 41328 | 48 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 2 / 280825 | 7 | |
| prostate | 9 / 189345 | 47 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 6 / 210574 | 28 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 3 / 96619 | 31 | |
| testis | 4 / 330442 | 12 | |
| thymus | 9 / 81131 | 110 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 3 / 52413 | 57 | |
| umbilical cord | 1 / 13680 | 73 | |
| uterus | 21 / 232878 | 90 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 209360_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.6 | |
| Adipocyte | 5 | |
| AdrenalCortex | 4.85 | |
| Adrenalgland | 3.9 | |
| Amygdala | 4.85 | |
| Appendix | 4.8 | |
| AtrioventricularNode | 3.8 | |
| BDCA4+_DentriticCells | 19.3 | |
| Bonemarrow | 4.8 | |
| BronchialEpithelialCells | 4.55 | |
| CD105+_Endothelial | 26.05 | |
| CD14+_Monocytes | 12.9 | |
| CD19+_BCells(neg._sel.) | 6.4 | |
| CD33+_Myeloid | 87.4 | |
| CD34+ | 411.55 |  |
| CD4+_Tcells | 36.15 | |
| CD56+_NKCells | 23.6 | |
| CD71+_EarlyErythroid | 4.2 | |
| CD8+_Tcells | 26.7 | |
| CardiacMyocytes | 6.35 | |
| Caudatenucleus | 4.15 | |
| Cerebellum | 3.8 | |
| CerebellumPeduncles | 5.25 | |
| CiliaryGanglion | 3.35 | |
| CingulateCortex | 4.75 | |
| Colorectaladenocarcinoma | 34.95 | |
| DorsalRootGanglion | 3.95 | |
| FetalThyroid | 4.4 | |
| Fetalbrain | 4.65 | |
| Fetalliver | 4.05 | |
| Fetallung | 4 | |
| GlobusPallidus | 3.3 | |
| Heart | 5.9 | |
| Hypothalamus | 4.9 | |
| Kidney | 3.75 | |
| Leukemia_chronicMyelogenousK-562 | 4.15 | |
| Leukemia_promyelocytic-HL-60 | 4.05 | |
| Leukemialymphoblastic(MOLT-4) | 189.3 | |
| Liver | 6.15 | |
| Lung | 8.35 | |
| Lymphnode | 4.3 | |
| Lymphoma_burkitts(Daudi) | 6.55 | |
| Lymphoma_burkitts(Raji) | 6.45 | |
| MedullaOblongata | 4.25 | |
| OccipitalLobe | 4.25 | |
| OlfactoryBulb | 3.7 | |
| Ovary | 3.1 | |
| Pancreas | 4 | |
| PancreaticIslet | 5.5 | |
| ParietalLobe | 4.9 | |
| Pituitary | 5.65 | |
| Placenta | 4.9 | |
| Pons | 4.4 | |
| PrefrontalCortex | 5.7 | |
| Prostate | 5.65 | |
| Salivarygland | 5.55 | |
| SkeletalMuscle | 5.3 | |
| Skin | 4.05 | |
| SmoothMuscle | 5.65 | |
| Spinalcord | 4.9 | |
| SubthalamicNucleus | 4.2 | |
| SuperiorCervicalGanglion | 6.25 | |
| TemporalLobe | 4.2 | |
| Testis | 3.9 | |
| TestisGermCell | 3.85 | |
| TestisIntersitial | 3.85 | |
| TestisLeydigCell | 4.6 | |
| TestisSeminiferousTubule | 4 | |
| Thalamus | 4.7 | |
| Thymus | 11.2 | |
| Thyroid | 5.85 | |
| Tongue | 4.55 | |
| Tonsil | 4.55 | |
| Trachea | 6.05 | |
| TrigeminalGanglion | 4.65 | |
| Uterus | 3.85 | |
| UterusCorpus | 5.9 | |
| WholeBlood | 7 | |
| Wholebrain | 3.75 | |
| colon | 4.75 | |
| pineal_day | 5.68 | |
| pineal_night | 5.58 | |
| retina | 5.675 | |
| small_intestine | 4.55 | |
- Probe name: A_24_P96403
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.85 ± 1.16 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.53 ± 0.51 | |
| Basal Part of Pons | 2.54 ± 0.63 | |
| Cerebellar Cortex | 2.21 ± 0.5 | |
| Cerebellar Nuclei | 3.13 ± 0.94 | |
| Claustrum | 2.93 ± 0.69 | |
| Epithalamus | 2.94 ± 0.76 | |
| Frontal Lobe | 2.6 ± 0.77 | |
| Globus Pallidus | 3.1 ± 0.57 | |
| Hypothalamus | 2.45 ± 0.94 | |
| Insula | 2.7 ± 0.73 | |
| Limbic Lobe | 2.55 ± 0.78 | |
| Mesencephalon | 2.72 ± 0.81 | |
| Myelencephalon | 2.83 ± 0.85 | |
| Occipital Lobe | 2.74 ± 0.73 | |
| Parietal Lobe | 2.81 ± 0.73 | |
| Pontine Tegmentum | 2.69 ± 0.77 | |
| Striatum | 4.4 ± 0.57 | |
| Subthalamus | 2.68 ± 0.76 | |
| Temporal Lobe | 2.45 ± 0.7 | |
| Thalamus | 2.49 ± 0.64 | |
| White Matter | 2 ± 0.25 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Runx1 | CB | Cerebellum | 1 | |
| 1.46 | | |||
| Runx1 | CTX | Cerebral cortex | 0.26 | |
| 0.32 | | |||
| Runx1 | HIP | Hippocampal region | 0.14 | |
| 0.2 | | |||
| Runx1 | HPF | Hippocampal formation | 0.14 | |
| 0.16 | | |||
| Runx1 | HY | Hypothalamus | 0.24 | |
| 0.27 | | |||
| Runx1 | LSX | Lateral septal complex | 0.08 | |
| 0.09 | | |||
| Runx1 | MB | Midbrain | 0.45 | |
| 0.56 | | |||
| Runx1 | MY | Medulla | 0.29 | |
| 0.37 | | |||
| Runx1 | OLF | Olfactory bulb | 0.54 | |
| 1.16 | | |||
| Runx1 | P | Pons | 0.37 | |
| 0.48 | | |||
| Runx1 | PAL | Pallidum | 0.14 | |
| 0.47 | | |||
| Runx1 | RHP | Retrohippocampal region | 0.12 | |
| 0.11 | | |||
| Runx1 | sAMY | Striatum-like amygdalar nuclei | 0.17 | |
| 0.23 | | |||
| Runx1 | STR | Striatum | 0.12 | |
| 0.15 | | |||
| Runx1 | STRd | Striatum dorsal region | 0.12 | |
| 0.11 | | |||
| Runx1 | STRv | Striatum ventral region | 0.12 | |
| 0.15 | | |||
| Runx1 | TH | Thalamus | 0.16 | |
| 0.2 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| RUNX1_HUMAN_50 | 15 | 50 | 64 | SMVEVLADHPGELVR | PRIDE |