AutismKB 2.0

Annotation Detail for PDE8B


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Basic Information Top
Gene Symbol:PDE8B ( ADSD,FLJ11212,PPNAD3 )
Gene Full Name: phosphodiesterase 8B
Band: 5q13.3
Quick LinksEntrez ID:8622; OMIM: 603390; Uniprot ID:PDE8B_HUMAN; ENSEMBL ID: ENSG00000113231; HGNC ID: 8794
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor4 / 34366116
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor1 / 2638453
glioma8 / 10688374
head and neck tumor20 / 136302146
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal65 / 336030719
ovarian tumor0 / 766820 
pancreatic tumor17 / 104616162
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain30 / 110098927
cervix4 / 4817183
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye2 / 2110549
heart5 / 8962655
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung9 / 33697426
lymph0 / 442700 
lymph node3 / 9161032
mammary gland1 / 1532716
mouth7 / 67052104
muscle1 / 1077159
nerve1 / 1576863
ovary0 / 1020510 
pancreas23 / 214812107
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate6 / 18934531
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid21 / 47473442
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213228_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.95
Adipocyte14
AdrenalCortex8.95
Adrenalgland7.1
Amygdala127.55
Appendix8.75
AtrioventricularNode6.4
BDCA4+_DentriticCells6.1
Bonemarrow8.45
BronchialEpithelialCells6.25
CD105+_Endothelial6.75
CD14+_Monocytes7.1
CD19+_BCells(neg._sel.)6.65
CD33+_Myeloid8.15
CD34+8.45
CD4+_Tcells7.05
CD56+_NKCells7.8
CD71+_EarlyErythroid6
CD8+_Tcells5.95
CardiacMyocytes10.05
Caudatenucleus42.9
Cerebellum6.5
CerebellumPeduncles9.15
CiliaryGanglion6.05
CingulateCortex68.7
Colorectaladenocarcinoma7.25
DorsalRootGanglion7.1
FetalThyroid1163.25
Fetalbrain20.4
Fetalliver6.25
Fetallung6.15
GlobusPallidus87.15
Heart10.55
Hypothalamus55
Kidney7.05
Leukemia_chronicMyelogenousK-5625.5
Leukemia_promyelocytic-HL-606
Leukemialymphoblastic(MOLT-4)5.15
Liver12.55
Lung8.55
Lymphnode6.7
Lymphoma_burkitts(Daudi)8.8
Lymphoma_burkitts(Raji)10.85
MedullaOblongata84.4
OccipitalLobe86.15
OlfactoryBulb5.6
Ovary6.55
Pancreas6.45
PancreaticIslet11.1
ParietalLobe52.9
Pituitary38.4
Placenta14.2
Pons31.95
PrefrontalCortex148.8
Prostate98.7
Salivarygland6.1
SkeletalMuscle10.05
Skin6.25
SmoothMuscle7.25
Spinalcord13.55
SubthalamicNucleus60.35
SuperiorCervicalGanglion10.1
TemporalLobe69.3
Testis7.35
TestisGermCell6.55
TestisIntersitial6.85
TestisLeydigCell10.4
TestisSeminiferousTubule7.6
Thalamus32.1
Thymus5.4
Thyroid679.8
Tongue8.2
Tonsil7.25
Trachea8.4
TrigeminalGanglion8.2
Uterus71.7
UterusCorpus24.8
WholeBlood7.85
Wholebrain92.2
colon9
pineal_day63.48
pineal_night28.7
retina15.725
small_intestine7.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9171_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.39 ± 0.48
Basal Forebrain6.62 ± 0.82
Basal Part of Pons7.1 ± 0.41
Cerebellar Cortex5.52 ± 0.5
Cerebellar Nuclei5.49 ± 0.61
Claustrum6.12 ± 1.21
Epithalamus5.61 ± 0.58
Frontal Lobe6.45 ± 0.56
Globus Pallidus5.9 ± 0.77
Hypothalamus6.88 ± 0.47
Insula6.57 ± 0.53
Limbic Lobe6.16 ± 0.71
Mesencephalon6.05 ± 0.58
Myelencephalon6.24 ± 0.71
Occipital Lobe6.44 ± 0.66
Parietal Lobe6.58 ± 0.61
Pontine Tegmentum6.33 ± 0.63
Striatum6.64 ± 0.89
Subthalamus6.05 ± 0.78
Temporal Lobe6.5 ± 0.48
Thalamus6.24 ± 0.57
White Matter4.87 ± 0.86
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pde8bCBCerebellum2.23
2.84
Pde8bCTXCerebral cortex48.2
37.31
Pde8bHIPHippocampal region17.01
26.99
Pde8bHPFHippocampal formation14.86
18.74
Pde8bHYHypothalamus6.54
5.26
Pde8bLSXLateral septal complex8.06
5.9
Pde8bMBMidbrain4.72
4.21
Pde8bMYMedulla4.53
5.39
Pde8bOLFOlfactory bulb20.26
17.9
Pde8bPPons4.08
4.39
Pde8bPALPallidum9.14
8.45
Pde8bRHPRetrohippocampal region12.62
10.92
Pde8bsAMYStriatum-like amygdalar nuclei13.67
10.14
Pde8bSTRStriatum36.24
29.94
Pde8bSTRdStriatum dorsal region33.73
25.09
Pde8bSTRvStriatum ventral region71.01
67.3
Pde8bTHThalamus1.33
1.25
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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