AutismKB 2.0

Annotation Detail for UNC5C


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Basic Information Top
Gene Symbol:UNC5C ( UNC5H3 )
Gene Full Name: unc-5 homolog C (C. elegans)
Band: 4q22.3
Quick LinksEntrez ID:8633; OMIM: 603610; Uniprot ID:UNC5C_HUMAN; ENSEMBL ID: ENSG00000182168; HGNC ID: 12569
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus19 / 56401233
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult31 / 193912115
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma3 / 10688328
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal69 / 336030720
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain39 / 110098935
cervix0 / 481710 
connective tissue1 / 1492556
ear1 / 1621261
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye2 / 2110549
heart1 / 8962611
intestine2 / 2344728
kidney4 / 21177718
larynx1 / 2414541
liver0 / 2077430 
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206189_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.5
Adipocyte4.4
AdrenalCortex4.85
Adrenalgland3.8
Amygdala4.7
Appendix4.65
AtrioventricularNode3.7
BDCA4+_DentriticCells4.65
Bonemarrow4.5
BronchialEpithelialCells4.3
CD105+_Endothelial4.45
CD14+_Monocytes4.65
CD19+_BCells(neg._sel.)4.8
CD33+_Myeloid5.55
CD34+5.5
CD4+_Tcells4.85
CD56+_NKCells5.15
CD71+_EarlyErythroid4.2
CD8+_Tcells4.2
CardiacMyocytes6.05
Caudatenucleus4
Cerebellum3.65
CerebellumPeduncles5.05
CiliaryGanglion3.3
CingulateCortex4.7
Colorectaladenocarcinoma4.45
DorsalRootGanglion3.5
FetalThyroid4.3
Fetalbrain4.3
Fetalliver3.85
Fetallung3.65
GlobusPallidus3.35
Heart5.75
Hypothalamus4.9
Kidney3.7
Leukemia_chronicMyelogenousK-5624
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)3.5
Liver6.2
Lung4.9
Lymphnode3.8
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)6.4
MedullaOblongata4.05
OccipitalLobe4.05
OlfactoryBulb3.55
Ovary2.95
Pancreas3.65
PancreaticIslet4.75
ParietalLobe4.75
Pituitary5.2
Placenta4.5
Pons4.3
PrefrontalCortex5.55
Prostate5.15
Salivarygland3.6
SkeletalMuscle5.45
Skin3.55
SmoothMuscle5
Spinalcord4.75
SubthalamicNucleus4.05
SuperiorCervicalGanglion5.35
TemporalLobe4.15
Testis3.85
TestisGermCell3.75
TestisIntersitial3.75
TestisLeydigCell4.4
TestisSeminiferousTubule3.8
Thalamus4.55
Thymus3.45
Thyroid5.5
Tongue4.5
Tonsil4.35
Trachea3.75
TrigeminalGanglion4.75
Uterus3.6
UterusCorpus4.25
WholeBlood4.85
Wholebrain3.85
colon4.5
pineal_day5.52
pineal_night5.42
retina6.05
small_intestine4.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P42624
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.21 ± 0.3
Basal Forebrain4.8 ± 0.32
Basal Part of Pons5.42 ± 0.38
Cerebellar Cortex5.02 ± 0.54
Cerebellar Nuclei5.01 ± 0.4
Claustrum5.37 ± 0.49
Epithalamus4.38 ± 0.6
Frontal Lobe4.88 ± 0.48
Globus Pallidus5.39 ± 0.4
Hypothalamus4.66 ± 0.41
Insula4.76 ± 0.31
Limbic Lobe4.91 ± 0.63
Mesencephalon4.83 ± 0.59
Myelencephalon4.99 ± 0.52
Occipital Lobe5.03 ± 0.51
Parietal Lobe4.88 ± 0.48
Pontine Tegmentum4.86 ± 0.44
Striatum4.73 ± 0.39
Subthalamus4.71 ± 0.82
Temporal Lobe4.93 ± 0.4
Thalamus5.08 ± 0.36
White Matter7.07 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Unc5cCBCerebellum14.96
15.43
Unc5cCTXCerebral cortex2.81
2.24
Unc5cHIPHippocampal region12.19
14.31
Unc5cHPFHippocampal formation10.54
10.81
Unc5cHYHypothalamus1.26
1.05
Unc5cLSXLateral septal complex0.51
0.41
Unc5cMBMidbrain1.6
1.45
Unc5cMYMedulla4.11
4.06
Unc5cOLFOlfactory bulb3.8
3.05
Unc5cPPons1.63
1.61
Unc5cPALPallidum0.9
0.86
Unc5cRHPRetrohippocampal region8.46
6.99
Unc5csAMYStriatum-like amygdalar nuclei1.45
1.19
Unc5cSTRStriatum0.92
0.78
Unc5cSTRdStriatum dorsal region0.79
0.67
Unc5cSTRvStriatum ventral region1.32
1.12
Unc5cTHThalamus10.23
8.95
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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