AutismKB 2.0

Annotation Detail for CHRD


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Basic Information Top
Gene Symbol:CHRD ( MGC133038 )
Gene Full Name: chordin
Band: 3q27.1
Quick LinksEntrez ID:8646; OMIM: 603475; Uniprot ID:CHRD_HUMAN; ENSEMBL ID: ENSG00000090539; HGNC ID: 1949
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus2 / 5640123
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult23 / 193912111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal94 / 336030727
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain67 / 110098960
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine1 / 2344724
kidney2 / 2117779
larynx0 / 241450 
liver4 / 20774319
lung1 / 3369742
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle7 / 10771564
nerve0 / 157680 
ovary1 / 1020519
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate4 / 18934521
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach2 / 9661920
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211248_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.55
Adipocyte5.3
AdrenalCortex5.6
Adrenalgland4.65
Amygdala5.95
Appendix5.4
AtrioventricularNode4.7
BDCA4+_DentriticCells5.8
Bonemarrow5.7
BronchialEpithelialCells5.25
CD105+_Endothelial5.5
CD14+_Monocytes5.75
CD19+_BCells(neg._sel.)5.7
CD33+_Myeloid7
CD34+6.8
CD4+_Tcells6.85
CD56+_NKCells6.25
CD71+_EarlyErythroid5.15
CD8+_Tcells5.1
CardiacMyocytes6.9
Caudatenucleus5.1
Cerebellum12.4
CerebellumPeduncles16.7
CiliaryGanglion3.85
CingulateCortex6
Colorectaladenocarcinoma5.45
DorsalRootGanglion4.55
FetalThyroid5.3
Fetalbrain5.5
Fetalliver5.1
Fetallung4.5
GlobusPallidus8.7
Heart7.55
Hypothalamus5.8
Kidney5.1
Leukemia_chronicMyelogenousK-5624.95
Leukemia_promyelocytic-HL-604.85
Leukemialymphoblastic(MOLT-4)4.3
Liver7.05
Lung5.9
Lymphnode4.7
Lymphoma_burkitts(Daudi)6.9
Lymphoma_burkitts(Raji)7.5
MedullaOblongata5
OccipitalLobe6.75
OlfactoryBulb4.3
Ovary4.35
Pancreas4.45
PancreaticIslet5.95
ParietalLobe7
Pituitary6.35
Placenta5.55
Pons5.25
PrefrontalCortex6.85
Prostate6.3
Salivarygland4.45
SkeletalMuscle6.35
Skin4.5
SmoothMuscle6.1
Spinalcord6.15
SubthalamicNucleus8.1
SuperiorCervicalGanglion6.6
TemporalLobe6
Testis4.7
TestisGermCell4.45
TestisIntersitial4.5
TestisLeydigCell5.4
TestisSeminiferousTubule4.65
Thalamus7.05
Thymus4.2
Thyroid6.8
Tongue5.25
Tonsil5.3
Trachea5.4
TrigeminalGanglion6.3
Uterus4.5
UterusCorpus5.25
WholeBlood5.9
Wholebrain4.8
colon5.45
pineal_day6.94
pineal_night8.16
retina6.6
small_intestine5.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P117725
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.45 ± 0.74
Basal Forebrain4.69 ± 0.18
Basal Part of Pons5.07 ± 0.44
Cerebellar Cortex5.53 ± 0.27
Cerebellar Nuclei4.53 ± 0.59
Claustrum5.62 ± 0.64
Epithalamus4.21 ± 0.65
Frontal Lobe4.94 ± 0.51
Globus Pallidus4.24 ± 0.53
Hypothalamus4.45 ± 0.69
Insula4.85 ± 0.38
Limbic Lobe5.19 ± 0.57
Mesencephalon4.74 ± 0.58
Myelencephalon4.91 ± 0.61
Occipital Lobe5.31 ± 0.49
Parietal Lobe4.98 ± 0.54
Pontine Tegmentum4.82 ± 0.65
Striatum4 ± 0.54
Subthalamus4.73 ± 0.43
Temporal Lobe4.91 ± 0.54
Thalamus4.78 ± 0.53
White Matter4.08 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ChrdCBCerebellum2.65
1.89
ChrdCTXCerebral cortex37.56
22.17
ChrdHIPHippocampal region70.01
73.8
ChrdHPFHippocampal formation70.08
62.87
ChrdHYHypothalamus1.12
0.64
ChrdLSXLateral septal complex3.12
2.39
ChrdMBMidbrain1.17
0.66
ChrdMYMedulla4.87
3.4
ChrdOLFOlfactory bulb28.27
15.94
ChrdPPons3.09
1.93
ChrdPALPallidum0.75
0.45
ChrdRHPRetrohippocampal region69.39
47.52
ChrdsAMYStriatum-like amygdalar nuclei7.51
4.59
ChrdSTRStriatum3.69
2.33
ChrdSTRdStriatum dorsal region2.12
1.36
ChrdSTRvStriatum ventral region6.52
3.72
ChrdTHThalamus2.33
1.57
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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